Abstract
Sphingosine-1-phosphate (S1P) is a bioactive lipid molecule. It stimulates the growth of some cells, but inhibits the growth of others. In this study, we describe the detection of sub-μM to μM concentrations of S1P in the ascitic fluids of patients with ovarian cancer. In ovarian cancer cells cultured in vitro, S1P exhibited a dual effect on growth and/or survival. S1P (10 μM) induced cell death when cells were in suspension but stimulated cell growth when cells were attached. The calcium-dependent induction of cell death by S1P is apparently associated with its inhibitory effect on cell attachment and cell adhesion. S1P (10-30 μM) also induced calcium-dependent cell-cell aggregation.
Original language | English (US) |
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Pages (from-to) | 513-518 |
Number of pages | 6 |
Journal | FEBS Letters |
Volume | 460 |
Issue number | 3 |
DOIs | |
State | Published - Nov 5 1999 |
Keywords
- Aggregation
- Cell adhesion
- Lysophosphatidic acid (LPA)
- Ovarian cancer
- Sphingosine-1-phosphate (S1P)
ASJC Scopus subject areas
- Biophysics
- Structural Biology
- Biochemistry
- Molecular Biology
- Genetics
- Cell Biology