Sphingosine-1-phosphate modulates growth and adhesion of ovarian cancer cells

Guiying Hong, Linnea M. Baudhuin, Yan Xu

Research output: Contribution to journalArticlepeer-review

80 Scopus citations

Abstract

Sphingosine-1-phosphate (S1P) is a bioactive lipid molecule. It stimulates the growth of some cells, but inhibits the growth of others. In this study, we describe the detection of sub-μM to μM concentrations of S1P in the ascitic fluids of patients with ovarian cancer. In ovarian cancer cells cultured in vitro, S1P exhibited a dual effect on growth and/or survival. S1P (10 μM) induced cell death when cells were in suspension but stimulated cell growth when cells were attached. The calcium-dependent induction of cell death by S1P is apparently associated with its inhibitory effect on cell attachment and cell adhesion. S1P (10-30 μM) also induced calcium-dependent cell-cell aggregation.

Original languageEnglish (US)
Pages (from-to)513-518
Number of pages6
JournalFEBS Letters
Volume460
Issue number3
DOIs
StatePublished - Nov 5 1999

Keywords

  • Aggregation
  • Cell adhesion
  • Lysophosphatidic acid (LPA)
  • Ovarian cancer
  • Sphingosine-1-phosphate (S1P)

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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