Sphingosine-1-phosphate modulates growth and adhesion of ovarian cancer cells

Guiying Hong; Linnea M. Baudhuin; Yan Xu

doi:10.1016/S0014-5793(99)01400-3

Sphingosine-1-phosphate modulates growth and adhesion of ovarian cancer cells

Guiying Hong, Linnea M. Baudhuin, Yan Xu

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

80 Scopus citations

Abstract

Sphingosine-1-phosphate (S1P) is a bioactive lipid molecule. It stimulates the growth of some cells, but inhibits the growth of others. In this study, we describe the detection of sub-μM to μM concentrations of S1P in the ascitic fluids of patients with ovarian cancer. In ovarian cancer cells cultured in vitro, S1P exhibited a dual effect on growth and/or survival. S1P (10 μM) induced cell death when cells were in suspension but stimulated cell growth when cells were attached. The calcium-dependent induction of cell death by S1P is apparently associated with its inhibitory effect on cell attachment and cell adhesion. S1P (10-30 μM) also induced calcium-dependent cell-cell aggregation.

Original language	English (US)
Pages (from-to)	513-518
Number of pages	6
Journal	FEBS Letters
Volume	460
Issue number	3
DOIs	https://doi.org/10.1016/S0014-5793(99)01400-3
State	Published - Nov 5 1999

Keywords

Aggregation
Cell adhesion
Lysophosphatidic acid (LPA)
Ovarian cancer
Sphingosine-1-phosphate (S1P)

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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title = "Sphingosine-1-phosphate modulates growth and adhesion of ovarian cancer cells",

abstract = "Sphingosine-1-phosphate (S1P) is a bioactive lipid molecule. It stimulates the growth of some cells, but inhibits the growth of others. In this study, we describe the detection of sub-μM to μM concentrations of S1P in the ascitic fluids of patients with ovarian cancer. In ovarian cancer cells cultured in vitro, S1P exhibited a dual effect on growth and/or survival. S1P (10 μM) induced cell death when cells were in suspension but stimulated cell growth when cells were attached. The calcium-dependent induction of cell death by S1P is apparently associated with its inhibitory effect on cell attachment and cell adhesion. S1P (10-30 μM) also induced calcium-dependent cell-cell aggregation.",

keywords = "Aggregation, Cell adhesion, Lysophosphatidic acid (LPA), Ovarian cancer, Sphingosine-1-phosphate (S1P)",

author = "Guiying Hong and Baudhuin, {Linnea M.} and Yan Xu",

note = "Funding Information: We thank Dr. Bryan Willams for his critical reading of this manuscript. This work is supported by American Cancer Society Grant RPG-99-062-01-CNE and an American Cancer Society Pilot Research grant (OHIO) Division) to Y.X.",

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AU - Hong, Guiying

AU - Baudhuin, Linnea M.

AU - Xu, Yan

N1 - Funding Information: We thank Dr. Bryan Willams for his critical reading of this manuscript. This work is supported by American Cancer Society Grant RPG-99-062-01-CNE and an American Cancer Society Pilot Research grant (OHIO) Division) to Y.X.

PY - 1999/11/5

Y1 - 1999/11/5

N2 - Sphingosine-1-phosphate (S1P) is a bioactive lipid molecule. It stimulates the growth of some cells, but inhibits the growth of others. In this study, we describe the detection of sub-μM to μM concentrations of S1P in the ascitic fluids of patients with ovarian cancer. In ovarian cancer cells cultured in vitro, S1P exhibited a dual effect on growth and/or survival. S1P (10 μM) induced cell death when cells were in suspension but stimulated cell growth when cells were attached. The calcium-dependent induction of cell death by S1P is apparently associated with its inhibitory effect on cell attachment and cell adhesion. S1P (10-30 μM) also induced calcium-dependent cell-cell aggregation.

AB - Sphingosine-1-phosphate (S1P) is a bioactive lipid molecule. It stimulates the growth of some cells, but inhibits the growth of others. In this study, we describe the detection of sub-μM to μM concentrations of S1P in the ascitic fluids of patients with ovarian cancer. In ovarian cancer cells cultured in vitro, S1P exhibited a dual effect on growth and/or survival. S1P (10 μM) induced cell death when cells were in suspension but stimulated cell growth when cells were attached. The calcium-dependent induction of cell death by S1P is apparently associated with its inhibitory effect on cell attachment and cell adhesion. S1P (10-30 μM) also induced calcium-dependent cell-cell aggregation.

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KW - Cell adhesion

KW - Lysophosphatidic acid (LPA)

KW - Ovarian cancer

KW - Sphingosine-1-phosphate (S1P)

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