Spectrum of Restrictive and Infiltrative Cardiomyopathies: Part 1 of a 2-Part Series

Research output: Contribution to journalReview article

14 Citations (Scopus)

Abstract

Restrictive cardiomyopathies are the least common form of heart muscle disease. They are characterized as infiltrative and noninfiltrative, storage diseases, and endomyocardial disorders. Genetic diseases commonly present during childhood or adolescence. However, a growing percentage of elderly patients with heart failure with preserved ejection fraction are being recognized as having forms of restrictive cardiomyopathy, particularly cardiac amyloidosis. Noninvasive evaluation has replaced endomyocardial biopsy in the diagnostic evaluation of most suspected etiologies. The detection of infiltrative cardiomyopathies, including lysosomal and glycogen storage disorders, iron overload, and amyloidosis (both light chain amyloidosis and transthyretin amyloidosis variants), as well as inflammatory diseases such as sarcoidosis has slowly led to improved outcomes via disease-specific therapies.

Original languageEnglish (US)
Pages (from-to)1130-1148
Number of pages19
JournalJournal of the American College of Cardiology
Volume71
Issue number10
DOIs
StatePublished - Mar 13 2018

Fingerprint

Restrictive Cardiomyopathy
Amyloidosis
Inborn Genetic Diseases
Iron Overload
Sarcoidosis
Glycogen
Cardiomyopathies
Heart Diseases
Myocardium
Heart Failure
Biopsy
Light
Therapeutics

Keywords

  • amyloidosis
  • heart failure
  • restrictive cardiomyopathy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Spectrum of Restrictive and Infiltrative Cardiomyopathies : Part 1 of a 2-Part Series. / Pereira, Naveen Luke; Grogan, Martha; Dec, G. William.

In: Journal of the American College of Cardiology, Vol. 71, No. 10, 13.03.2018, p. 1130-1148.

Research output: Contribution to journalReview article

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