Spectral analysis of slow modulation of EEG amplitude and cardiovascular variables in subjects with postural tachycardia syndrome

Terrence D. Lagerlund, Phillip Anson Low, Vera Novak, Peter Novak, Stacy M. Hines, Benjamin McPhee, Neil E. Busacker

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Previous studies have reported slow (<0.5 Hz) modulation of electroencephalographic (EEG) background amplitude and suggested that this reflects periodic neuronal activity in the brainstem, such as may be recorded from cardiovascular and respiratory centers in animals. We searched for a relationship between EEG amplitude modulation and modulation of simultaneously recorded cardiovascular variables and attempted to determine whether this relationship was altered in subjects with postural tachycardia syndrome (POTS). We recorded EEG, blood flow velocity in the middle cerebral artery (MCA), heart rate, respirations, and blood pressure from subjects with POTS and controls during head-up tilt. Time-frequency analysis of 0.512-s epochs of EEG was performed to determine peak α amplitude. Spectra were divided into 3 bands: ultraslow, middle, and respiratory. EEG α amplitude modulation in all frequency bands was reduced in POTS subjects while supine. EEG modulation decreased in controls with head-up tilt but not in POTS subjects. Heart rate modulation in the respiratory frequency band decreased with head-up tilt and was significantly less (P<0.02) in ultraslow and respiratory frequency bands in POTS subjects after head-up tilt. Blood pressure and MCA flow velocity modulation in middle and respiratory bands increased with head-up tilt to a greater degree in POTS subjects. Blood pressure and MCA flow velocity modulation frequencies were moderately correlated, but correlations between EEG and cardiovascular variable modulation frequencies were generally low, being highest in the respiratory band but not statistically significant. There are subtle differences in EEG amplitude modulation in subjects with POTS. Altered EEG amplitude modulation in POTS may reflect altered brainstem physiology in this disorder.

Original languageEnglish (US)
Pages (from-to)132-142
Number of pages11
JournalAutonomic Neuroscience: Basic and Clinical
Volume117
Issue number2
DOIs
StatePublished - Feb 7 2005

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Postural Orthostatic Tachycardia Syndrome
Head
Middle Cerebral Artery
Blood Pressure
Brain Stem
Heart Rate
Respiratory Center
Blood Flow Velocity
Respiration

Keywords

  • Autonomic disorders
  • Postural tachycardia syndrome
  • Power spectral analysis
  • Slow modulation cardiovascular variables
  • Slow modulation of EEG amplitude

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Endocrine and Autonomic Systems

Cite this

Spectral analysis of slow modulation of EEG amplitude and cardiovascular variables in subjects with postural tachycardia syndrome. / Lagerlund, Terrence D.; Low, Phillip Anson; Novak, Vera; Novak, Peter; Hines, Stacy M.; McPhee, Benjamin; Busacker, Neil E.

In: Autonomic Neuroscience: Basic and Clinical, Vol. 117, No. 2, 07.02.2005, p. 132-142.

Research output: Contribution to journalArticle

Lagerlund, Terrence D. ; Low, Phillip Anson ; Novak, Vera ; Novak, Peter ; Hines, Stacy M. ; McPhee, Benjamin ; Busacker, Neil E. / Spectral analysis of slow modulation of EEG amplitude and cardiovascular variables in subjects with postural tachycardia syndrome. In: Autonomic Neuroscience: Basic and Clinical. 2005 ; Vol. 117, No. 2. pp. 132-142.
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