Species difference in the effect of indomethacin on the development of acute circulatory renal failure

V. E. Torres, J. C. Romero, C. G. Strong, M. Huguenin, D. M. Wilson

Research output: Contribution to journalArticle

Abstract

The effect of indomethacin treatment on the development of acute renal failure induced by two different doses of glycerol or by mercuric chloride was studied in rats and rabbits. The overall effect of this treatment was assessed by measuring changes in plasma creatinine level. In rabbits, indomethacin enhanced the severity of glycerol induced acute renal failure but had no effect on acute renal failure induced by mercuric chloride. The severity of glycerol induced or mercuric chloride induced acute renal failure in rats was not increased by indomethacin. On the contrary, average plasma creatinine levels of the experimental groups treated with indomethacin were found slightly decreased when compared with those of the controls.

Original languageEnglish (US)
Pages (from-to)539-542
Number of pages4
JournalActa Physiologica Latino-Americana
Volume24
Issue number5
StatePublished - Dec 1 1974

ASJC Scopus subject areas

  • Physiology
  • Pharmacology

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