Spatiotemporal intracellular nitric oxide signaling captured using internalized, near-infrared fluorescent carbon nanotube nanosensors

Zachary W. Ulissi, Fatih Sen, Xun Gong, Selda Sen, Nicole Iverson, Ardemis A. Boghossian, Luiz C. Godoy, Gerald N. Wogan, Debabrata Mukhopadhyay, Michael S. Strano

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

Fluorescent nanosensor probes have suffered from limited molecular recognition and a dearth of strategies for spatial-temporal operation in cell culture. In this work, we spatially imaged the dynamics of nitric oxide (NO) signaling, important in numerous pathologies and physiological functions, using intracellular near-infrared fluorescent single-walled carbon nanotubes. The observed spatial-temporal NO signaling gradients clarify and refine the existing paradigm of NO signaling based on averaged local concentrations. This work enables the study of transient intracellular phenomena associated with signaling and therapeutics.

Original languageEnglish (US)
Pages (from-to)4887-4894
Number of pages8
JournalNano Letters
Volume14
Issue number8
DOIs
StatePublished - Aug 13 2014

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Keywords

  • nitric oxide
  • photoluminescence
  • sensor
  • Single-walled carbon nanotube

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Mechanical Engineering

Cite this

Ulissi, Z. W., Sen, F., Gong, X., Sen, S., Iverson, N., Boghossian, A. A., Godoy, L. C., Wogan, G. N., Mukhopadhyay, D., & Strano, M. S. (2014). Spatiotemporal intracellular nitric oxide signaling captured using internalized, near-infrared fluorescent carbon nanotube nanosensors. Nano Letters, 14(8), 4887-4894. https://doi.org/10.1021/nl502338y