Spatiotemporal intracellular nitric oxide signaling captured using internalized, near-infrared fluorescent carbon nanotube nanosensors

Zachary W. Ulissi, Fatih Sen, Xun Gong, Selda Sen, Nicole Iverson, Ardemis A. Boghossian, Luiz C. Godoy, Gerald N. Wogan, Debabrata Mukhopadhyay, Michael S. Strano

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Fluorescent nanosensor probes have suffered from limited molecular recognition and a dearth of strategies for spatial-temporal operation in cell culture. In this work, we spatially imaged the dynamics of nitric oxide (NO) signaling, important in numerous pathologies and physiological functions, using intracellular near-infrared fluorescent single-walled carbon nanotubes. The observed spatial-temporal NO signaling gradients clarify and refine the existing paradigm of NO signaling based on averaged local concentrations. This work enables the study of transient intracellular phenomena associated with signaling and therapeutics.

Original languageEnglish (US)
Pages (from-to)4887-4894
Number of pages8
JournalNano Letters
Volume14
Issue number8
DOIs
StatePublished - Aug 13 2014

Fingerprint

Nanosensors
Carbon Nanotubes
Nitric oxide
nitric oxide
Carbon nanotubes
Nitric Oxide
carbon nanotubes
Infrared radiation
pathology
Molecular recognition
Pathology
Single-walled carbon nanotubes (SWCN)
Fluorescent Dyes
Cell culture
gradients
probes

Keywords

  • nitric oxide
  • photoluminescence
  • sensor
  • Single-walled carbon nanotube

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Mechanical Engineering

Cite this

Ulissi, Z. W., Sen, F., Gong, X., Sen, S., Iverson, N., Boghossian, A. A., ... Strano, M. S. (2014). Spatiotemporal intracellular nitric oxide signaling captured using internalized, near-infrared fluorescent carbon nanotube nanosensors. Nano Letters, 14(8), 4887-4894. https://doi.org/10.1021/nl502338y

Spatiotemporal intracellular nitric oxide signaling captured using internalized, near-infrared fluorescent carbon nanotube nanosensors. / Ulissi, Zachary W.; Sen, Fatih; Gong, Xun; Sen, Selda; Iverson, Nicole; Boghossian, Ardemis A.; Godoy, Luiz C.; Wogan, Gerald N.; Mukhopadhyay, Debabrata; Strano, Michael S.

In: Nano Letters, Vol. 14, No. 8, 13.08.2014, p. 4887-4894.

Research output: Contribution to journalArticle

Ulissi, ZW, Sen, F, Gong, X, Sen, S, Iverson, N, Boghossian, AA, Godoy, LC, Wogan, GN, Mukhopadhyay, D & Strano, MS 2014, 'Spatiotemporal intracellular nitric oxide signaling captured using internalized, near-infrared fluorescent carbon nanotube nanosensors', Nano Letters, vol. 14, no. 8, pp. 4887-4894. https://doi.org/10.1021/nl502338y
Ulissi, Zachary W. ; Sen, Fatih ; Gong, Xun ; Sen, Selda ; Iverson, Nicole ; Boghossian, Ardemis A. ; Godoy, Luiz C. ; Wogan, Gerald N. ; Mukhopadhyay, Debabrata ; Strano, Michael S. / Spatiotemporal intracellular nitric oxide signaling captured using internalized, near-infrared fluorescent carbon nanotube nanosensors. In: Nano Letters. 2014 ; Vol. 14, No. 8. pp. 4887-4894.
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