Spatial heterogeneity of neoatherosclerosis and its relationship with neovascularization and adjacent plaque characteristics: Optical coherence tomography study

Jinwei Tian, Xuefeng Ren, Shiro Uemura, Harold Dauerman, Abhiram Prasad, Catalin Toma, Haibo Jia, Farhad Abtahian, Rocco Vergallo, Sining Hu, Iris McNulty, Hang Lee, Stephen Lee, Bo Yu, Ik Kyung Jang

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background Development of neoatherosclerosis (NA) has been reported to be a potential cause of late stent failure. However, the distribution of NA and its relationship with neovascularization (NV) and adjacent plaque characteristics remain unclear. Methods We investigated 167 stents (40 bare-metal stents, 84 sirolimus-eluting stents, and 43 everolimus-eluting stents) with optical coherence tomography. Each stent was divided into the proximal section (PS), mid section (MS) and distal section (DS). Neoatherosclerosis was defined as lipid-laden neointima or calcification inside stent. Adjacent plaque characteristics were evaluated within 5 mm proximal and distal reference segments. Results Neoatherosclerosis was more frequent in PS and DS than in MS (PS 19.8% vs MS 3.6% vs DS 21%: PS vs MS, P <.001: MS vs DS, P <.001). Neovascularization in PS and DS was also more prevalent compared with that in MS (PS 15% vs MS 5.4% vs DS 13.8%: PS vs MS, P =.001: MS vs DS, P =.001). Neoatherosclerosis was more frequently observed in stents with intraintima NV (68.6% vs 20.5%, P <.001). The incidence of NA was higher, when adjacent plaque was lipid (43.2% with lipid plaque vs 12.2% without lipid plaque, P <.001). Conclusion Neoatherosclerosis occurs more frequently at PS and DS. Neoatherosclerosis was associated with NV and adjacent lipid plaque, suggesting potential interrelationship between development of NA and NV and adjacent plaque characteristics.

Original languageEnglish (US)
JournalAmerican Heart Journal
Volume167
Issue number6
DOIs
StatePublished - 2014

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Optical Coherence Tomography
Stents
Lipids
Neointima
Sirolimus
Metals
Incidence

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Spatial heterogeneity of neoatherosclerosis and its relationship with neovascularization and adjacent plaque characteristics : Optical coherence tomography study. / Tian, Jinwei; Ren, Xuefeng; Uemura, Shiro; Dauerman, Harold; Prasad, Abhiram; Toma, Catalin; Jia, Haibo; Abtahian, Farhad; Vergallo, Rocco; Hu, Sining; McNulty, Iris; Lee, Hang; Lee, Stephen; Yu, Bo; Jang, Ik Kyung.

In: American Heart Journal, Vol. 167, No. 6, 2014.

Research output: Contribution to journalArticle

Tian, J, Ren, X, Uemura, S, Dauerman, H, Prasad, A, Toma, C, Jia, H, Abtahian, F, Vergallo, R, Hu, S, McNulty, I, Lee, H, Lee, S, Yu, B & Jang, IK 2014, 'Spatial heterogeneity of neoatherosclerosis and its relationship with neovascularization and adjacent plaque characteristics: Optical coherence tomography study', American Heart Journal, vol. 167, no. 6. https://doi.org/10.1016/j.ahj.2014.03.013
Tian, Jinwei ; Ren, Xuefeng ; Uemura, Shiro ; Dauerman, Harold ; Prasad, Abhiram ; Toma, Catalin ; Jia, Haibo ; Abtahian, Farhad ; Vergallo, Rocco ; Hu, Sining ; McNulty, Iris ; Lee, Hang ; Lee, Stephen ; Yu, Bo ; Jang, Ik Kyung. / Spatial heterogeneity of neoatherosclerosis and its relationship with neovascularization and adjacent plaque characteristics : Optical coherence tomography study. In: American Heart Journal. 2014 ; Vol. 167, No. 6.
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abstract = "Background Development of neoatherosclerosis (NA) has been reported to be a potential cause of late stent failure. However, the distribution of NA and its relationship with neovascularization (NV) and adjacent plaque characteristics remain unclear. Methods We investigated 167 stents (40 bare-metal stents, 84 sirolimus-eluting stents, and 43 everolimus-eluting stents) with optical coherence tomography. Each stent was divided into the proximal section (PS), mid section (MS) and distal section (DS). Neoatherosclerosis was defined as lipid-laden neointima or calcification inside stent. Adjacent plaque characteristics were evaluated within 5 mm proximal and distal reference segments. Results Neoatherosclerosis was more frequent in PS and DS than in MS (PS 19.8{\%} vs MS 3.6{\%} vs DS 21{\%}: PS vs MS, P <.001: MS vs DS, P <.001). Neovascularization in PS and DS was also more prevalent compared with that in MS (PS 15{\%} vs MS 5.4{\%} vs DS 13.8{\%}: PS vs MS, P =.001: MS vs DS, P =.001). Neoatherosclerosis was more frequently observed in stents with intraintima NV (68.6{\%} vs 20.5{\%}, P <.001). The incidence of NA was higher, when adjacent plaque was lipid (43.2{\%} with lipid plaque vs 12.2{\%} without lipid plaque, P <.001). Conclusion Neoatherosclerosis occurs more frequently at PS and DS. Neoatherosclerosis was associated with NV and adjacent lipid plaque, suggesting potential interrelationship between development of NA and NV and adjacent plaque characteristics.",
author = "Jinwei Tian and Xuefeng Ren and Shiro Uemura and Harold Dauerman and Abhiram Prasad and Catalin Toma and Haibo Jia and Farhad Abtahian and Rocco Vergallo and Sining Hu and Iris McNulty and Hang Lee and Stephen Lee and Bo Yu and Jang, {Ik Kyung}",
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TY - JOUR

T1 - Spatial heterogeneity of neoatherosclerosis and its relationship with neovascularization and adjacent plaque characteristics

T2 - Optical coherence tomography study

AU - Tian, Jinwei

AU - Ren, Xuefeng

AU - Uemura, Shiro

AU - Dauerman, Harold

AU - Prasad, Abhiram

AU - Toma, Catalin

AU - Jia, Haibo

AU - Abtahian, Farhad

AU - Vergallo, Rocco

AU - Hu, Sining

AU - McNulty, Iris

AU - Lee, Hang

AU - Lee, Stephen

AU - Yu, Bo

AU - Jang, Ik Kyung

PY - 2014

Y1 - 2014

N2 - Background Development of neoatherosclerosis (NA) has been reported to be a potential cause of late stent failure. However, the distribution of NA and its relationship with neovascularization (NV) and adjacent plaque characteristics remain unclear. Methods We investigated 167 stents (40 bare-metal stents, 84 sirolimus-eluting stents, and 43 everolimus-eluting stents) with optical coherence tomography. Each stent was divided into the proximal section (PS), mid section (MS) and distal section (DS). Neoatherosclerosis was defined as lipid-laden neointima or calcification inside stent. Adjacent plaque characteristics were evaluated within 5 mm proximal and distal reference segments. Results Neoatherosclerosis was more frequent in PS and DS than in MS (PS 19.8% vs MS 3.6% vs DS 21%: PS vs MS, P <.001: MS vs DS, P <.001). Neovascularization in PS and DS was also more prevalent compared with that in MS (PS 15% vs MS 5.4% vs DS 13.8%: PS vs MS, P =.001: MS vs DS, P =.001). Neoatherosclerosis was more frequently observed in stents with intraintima NV (68.6% vs 20.5%, P <.001). The incidence of NA was higher, when adjacent plaque was lipid (43.2% with lipid plaque vs 12.2% without lipid plaque, P <.001). Conclusion Neoatherosclerosis occurs more frequently at PS and DS. Neoatherosclerosis was associated with NV and adjacent lipid plaque, suggesting potential interrelationship between development of NA and NV and adjacent plaque characteristics.

AB - Background Development of neoatherosclerosis (NA) has been reported to be a potential cause of late stent failure. However, the distribution of NA and its relationship with neovascularization (NV) and adjacent plaque characteristics remain unclear. Methods We investigated 167 stents (40 bare-metal stents, 84 sirolimus-eluting stents, and 43 everolimus-eluting stents) with optical coherence tomography. Each stent was divided into the proximal section (PS), mid section (MS) and distal section (DS). Neoatherosclerosis was defined as lipid-laden neointima or calcification inside stent. Adjacent plaque characteristics were evaluated within 5 mm proximal and distal reference segments. Results Neoatherosclerosis was more frequent in PS and DS than in MS (PS 19.8% vs MS 3.6% vs DS 21%: PS vs MS, P <.001: MS vs DS, P <.001). Neovascularization in PS and DS was also more prevalent compared with that in MS (PS 15% vs MS 5.4% vs DS 13.8%: PS vs MS, P =.001: MS vs DS, P =.001). Neoatherosclerosis was more frequently observed in stents with intraintima NV (68.6% vs 20.5%, P <.001). The incidence of NA was higher, when adjacent plaque was lipid (43.2% with lipid plaque vs 12.2% without lipid plaque, P <.001). Conclusion Neoatherosclerosis occurs more frequently at PS and DS. Neoatherosclerosis was associated with NV and adjacent lipid plaque, suggesting potential interrelationship between development of NA and NV and adjacent plaque characteristics.

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U2 - 10.1016/j.ahj.2014.03.013

DO - 10.1016/j.ahj.2014.03.013

M3 - Article

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AN - SCOPUS:84901816741

VL - 167

JO - American Heart Journal

JF - American Heart Journal

SN - 0002-8703

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