TY - JOUR
T1 - Spatial heterogeneity of neoatherosclerosis and its relationship with neovascularization and adjacent plaque characteristics
T2 - Optical coherence tomography study
AU - Tian, Jinwei
AU - Ren, Xuefeng
AU - Uemura, Shiro
AU - Dauerman, Harold
AU - Prasad, Abhiram
AU - Toma, Catalin
AU - Jia, Haibo
AU - Abtahian, Farhad
AU - Vergallo, Rocco
AU - Hu, Sining
AU - McNulty, Iris
AU - Lee, Hang
AU - Lee, Stephen
AU - Yu, Bo
AU - Jang, Ik Kyung
PY - 2014/6
Y1 - 2014/6
N2 - Background Development of neoatherosclerosis (NA) has been reported to be a potential cause of late stent failure. However, the distribution of NA and its relationship with neovascularization (NV) and adjacent plaque characteristics remain unclear. Methods We investigated 167 stents (40 bare-metal stents, 84 sirolimus-eluting stents, and 43 everolimus-eluting stents) with optical coherence tomography. Each stent was divided into the proximal section (PS), mid section (MS) and distal section (DS). Neoatherosclerosis was defined as lipid-laden neointima or calcification inside stent. Adjacent plaque characteristics were evaluated within 5 mm proximal and distal reference segments. Results Neoatherosclerosis was more frequent in PS and DS than in MS (PS 19.8% vs MS 3.6% vs DS 21%: PS vs MS, P <.001: MS vs DS, P <.001). Neovascularization in PS and DS was also more prevalent compared with that in MS (PS 15% vs MS 5.4% vs DS 13.8%: PS vs MS, P =.001: MS vs DS, P =.001). Neoatherosclerosis was more frequently observed in stents with intraintima NV (68.6% vs 20.5%, P <.001). The incidence of NA was higher, when adjacent plaque was lipid (43.2% with lipid plaque vs 12.2% without lipid plaque, P <.001). Conclusion Neoatherosclerosis occurs more frequently at PS and DS. Neoatherosclerosis was associated with NV and adjacent lipid plaque, suggesting potential interrelationship between development of NA and NV and adjacent plaque characteristics.
AB - Background Development of neoatherosclerosis (NA) has been reported to be a potential cause of late stent failure. However, the distribution of NA and its relationship with neovascularization (NV) and adjacent plaque characteristics remain unclear. Methods We investigated 167 stents (40 bare-metal stents, 84 sirolimus-eluting stents, and 43 everolimus-eluting stents) with optical coherence tomography. Each stent was divided into the proximal section (PS), mid section (MS) and distal section (DS). Neoatherosclerosis was defined as lipid-laden neointima or calcification inside stent. Adjacent plaque characteristics were evaluated within 5 mm proximal and distal reference segments. Results Neoatherosclerosis was more frequent in PS and DS than in MS (PS 19.8% vs MS 3.6% vs DS 21%: PS vs MS, P <.001: MS vs DS, P <.001). Neovascularization in PS and DS was also more prevalent compared with that in MS (PS 15% vs MS 5.4% vs DS 13.8%: PS vs MS, P =.001: MS vs DS, P =.001). Neoatherosclerosis was more frequently observed in stents with intraintima NV (68.6% vs 20.5%, P <.001). The incidence of NA was higher, when adjacent plaque was lipid (43.2% with lipid plaque vs 12.2% without lipid plaque, P <.001). Conclusion Neoatherosclerosis occurs more frequently at PS and DS. Neoatherosclerosis was associated with NV and adjacent lipid plaque, suggesting potential interrelationship between development of NA and NV and adjacent plaque characteristics.
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U2 - 10.1016/j.ahj.2014.03.013
DO - 10.1016/j.ahj.2014.03.013
M3 - Article
C2 - 24890539
AN - SCOPUS:84901816741
SN - 0002-8703
VL - 167
SP - 884-892.e2
JO - American heart journal
JF - American heart journal
IS - 6
ER -