Spatial correlates of hippocampal unit activity are altered by lesions of the fornix and entorhinal cortex

Virginia M Miller, Phillip J. Best

Research output: Contribution to journalArticle

120 Citations (Scopus)

Abstract

Behavioral and electrophysiological evidence supports the role of the hippocampus in the processing of spatial information. In the present study, neuronal activity recorded from chronically implanted hippocampal microelectrodes was correlated with a rat's spatial orientation while traversing a radial maze for food reward. Place units were found in all fields of the dorsal hippocampus and dentate gyrus. Rotation of the maze relative to extramaze cues failed to disrupt the intact animal's spatial task performance or the spatial correlates of the unit activity. Lesions of the fornix or entorhinal cortex disrupted performance of the task. Unit activity correlated to the animal's spatial orientation was also disrupted by either lesion. There was no correlation between the disruption of the unit activity and location of the unit within hippocampal fields. Unit activity from lesioned animals showed correlation to the physical properties of the maze rather than to the orientation of the maze in space. These results further support the role of the hippocampus in the processing of spatial information.

Original languageEnglish (US)
Pages (from-to)311-323
Number of pages13
JournalBrain Research
Volume194
Issue number2
DOIs
StatePublished - Aug 4 1980
Externally publishedYes

Fingerprint

Entorhinal Cortex
Hippocampus
Task Performance and Analysis
Automatic Data Processing
Dentate Gyrus
Microelectrodes
Reward
Cues
Food
Spatial Processing
Spatial Orientation

Keywords

  • entorhinal lesions
  • fornix lesions
  • hippocampus
  • spatial behavior
  • spatial cells

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Spatial correlates of hippocampal unit activity are altered by lesions of the fornix and entorhinal cortex. / Miller, Virginia M; Best, Phillip J.

In: Brain Research, Vol. 194, No. 2, 04.08.1980, p. 311-323.

Research output: Contribution to journalArticle

@article{74ae1df1c0ed4bdb9d29961d0a513411,
title = "Spatial correlates of hippocampal unit activity are altered by lesions of the fornix and entorhinal cortex",
abstract = "Behavioral and electrophysiological evidence supports the role of the hippocampus in the processing of spatial information. In the present study, neuronal activity recorded from chronically implanted hippocampal microelectrodes was correlated with a rat's spatial orientation while traversing a radial maze for food reward. Place units were found in all fields of the dorsal hippocampus and dentate gyrus. Rotation of the maze relative to extramaze cues failed to disrupt the intact animal's spatial task performance or the spatial correlates of the unit activity. Lesions of the fornix or entorhinal cortex disrupted performance of the task. Unit activity correlated to the animal's spatial orientation was also disrupted by either lesion. There was no correlation between the disruption of the unit activity and location of the unit within hippocampal fields. Unit activity from lesioned animals showed correlation to the physical properties of the maze rather than to the orientation of the maze in space. These results further support the role of the hippocampus in the processing of spatial information.",
keywords = "entorhinal lesions, fornix lesions, hippocampus, spatial behavior, spatial cells",
author = "Miller, {Virginia M} and Best, {Phillip J.}",
year = "1980",
month = "8",
day = "4",
doi = "10.1016/0006-8993(80)91214-7",
language = "English (US)",
volume = "194",
pages = "311--323",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - Spatial correlates of hippocampal unit activity are altered by lesions of the fornix and entorhinal cortex

AU - Miller, Virginia M

AU - Best, Phillip J.

PY - 1980/8/4

Y1 - 1980/8/4

N2 - Behavioral and electrophysiological evidence supports the role of the hippocampus in the processing of spatial information. In the present study, neuronal activity recorded from chronically implanted hippocampal microelectrodes was correlated with a rat's spatial orientation while traversing a radial maze for food reward. Place units were found in all fields of the dorsal hippocampus and dentate gyrus. Rotation of the maze relative to extramaze cues failed to disrupt the intact animal's spatial task performance or the spatial correlates of the unit activity. Lesions of the fornix or entorhinal cortex disrupted performance of the task. Unit activity correlated to the animal's spatial orientation was also disrupted by either lesion. There was no correlation between the disruption of the unit activity and location of the unit within hippocampal fields. Unit activity from lesioned animals showed correlation to the physical properties of the maze rather than to the orientation of the maze in space. These results further support the role of the hippocampus in the processing of spatial information.

AB - Behavioral and electrophysiological evidence supports the role of the hippocampus in the processing of spatial information. In the present study, neuronal activity recorded from chronically implanted hippocampal microelectrodes was correlated with a rat's spatial orientation while traversing a radial maze for food reward. Place units were found in all fields of the dorsal hippocampus and dentate gyrus. Rotation of the maze relative to extramaze cues failed to disrupt the intact animal's spatial task performance or the spatial correlates of the unit activity. Lesions of the fornix or entorhinal cortex disrupted performance of the task. Unit activity correlated to the animal's spatial orientation was also disrupted by either lesion. There was no correlation between the disruption of the unit activity and location of the unit within hippocampal fields. Unit activity from lesioned animals showed correlation to the physical properties of the maze rather than to the orientation of the maze in space. These results further support the role of the hippocampus in the processing of spatial information.

KW - entorhinal lesions

KW - fornix lesions

KW - hippocampus

KW - spatial behavior

KW - spatial cells

UR - http://www.scopus.com/inward/record.url?scp=0018826262&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018826262&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(80)91214-7

DO - 10.1016/0006-8993(80)91214-7

M3 - Article

VL - 194

SP - 311

EP - 323

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 2

ER -