Space occupying lesions in the presence of congenital diaphragmatic hernia

Stephanie M. Cruz, Adesola C. Akinkuotu, Darrell L. Cass, Timothy C. Lee, Christopher I. Cassady, Amy R. Mehollin-Ray, Rodrigo Ruano, Stephen E. Welty, Oluyinka O. Olutoye

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Introduction Previous reports describe lung malformations and other chest lesions in association with congenital diaphragmatic hernia (CDH), yet little is known how these lesions affect outcomes. We sought to evaluate the incidence and outcomes of patients diagnosed with chest lesions in association with CDH. Methods The charts of all infants treated for CDH in a single tertiary center from January 2004 to January 2015 were reviewed. The outcomes of those with space occupying lesions (SOLs) in association with CDH were compared to those with isolated CDH. Statistical analysis was performed using Student's t-test and Mann-Whitney U test for continuous variables and Fisher's exact for categorical variables. Results Of the 214 infants treated, 20 had an associated SOL (4 had > 1 lesion). SOLs were confirmed by pathological examination and included: bronchopulmonary sequestration (n = 10; 4.7%), ectopic liver (n = 9; 4.2%), foregut duplication cyst (n = 2; 1%), and other lesions (n = 3; 1.4%). No statistical difference was noted in the long-term outcomes of patients with SOL in comparison to those with isolated CDH. Conclusion SOLs are not uncommon in neonates with CDH. Despite theoretical concerns, there is no evidence that SOLs are associated with worse outcomes, a finding which is helpful during prenatal counseling of families.

Original languageEnglish (US)
Pages (from-to)710-713
Number of pages4
JournalJournal of Pediatric Surgery
Volume51
Issue number5
DOIs
StatePublished - May 1 2016
Externally publishedYes

Fingerprint

Thorax
Bronchopulmonary Sequestration
Nonparametric Statistics
Congenital Diaphragmatic Hernias
Cysts
Counseling
Newborn Infant
Students
Lung
Liver
Incidence

Keywords

  • Diaphragmatic hernia
  • Duplication cyst
  • Ectopic liver
  • Pulmonary sequestration

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health

Cite this

Cruz, S. M., Akinkuotu, A. C., Cass, D. L., Lee, T. C., Cassady, C. I., Mehollin-Ray, A. R., ... Olutoye, O. O. (2016). Space occupying lesions in the presence of congenital diaphragmatic hernia. Journal of Pediatric Surgery, 51(5), 710-713. https://doi.org/10.1016/j.jpedsurg.2016.02.009

Space occupying lesions in the presence of congenital diaphragmatic hernia. / Cruz, Stephanie M.; Akinkuotu, Adesola C.; Cass, Darrell L.; Lee, Timothy C.; Cassady, Christopher I.; Mehollin-Ray, Amy R.; Ruano, Rodrigo; Welty, Stephen E.; Olutoye, Oluyinka O.

In: Journal of Pediatric Surgery, Vol. 51, No. 5, 01.05.2016, p. 710-713.

Research output: Contribution to journalArticle

Cruz, SM, Akinkuotu, AC, Cass, DL, Lee, TC, Cassady, CI, Mehollin-Ray, AR, Ruano, R, Welty, SE & Olutoye, OO 2016, 'Space occupying lesions in the presence of congenital diaphragmatic hernia', Journal of Pediatric Surgery, vol. 51, no. 5, pp. 710-713. https://doi.org/10.1016/j.jpedsurg.2016.02.009
Cruz SM, Akinkuotu AC, Cass DL, Lee TC, Cassady CI, Mehollin-Ray AR et al. Space occupying lesions in the presence of congenital diaphragmatic hernia. Journal of Pediatric Surgery. 2016 May 1;51(5):710-713. https://doi.org/10.1016/j.jpedsurg.2016.02.009
Cruz, Stephanie M. ; Akinkuotu, Adesola C. ; Cass, Darrell L. ; Lee, Timothy C. ; Cassady, Christopher I. ; Mehollin-Ray, Amy R. ; Ruano, Rodrigo ; Welty, Stephen E. ; Olutoye, Oluyinka O. / Space occupying lesions in the presence of congenital diaphragmatic hernia. In: Journal of Pediatric Surgery. 2016 ; Vol. 51, No. 5. pp. 710-713.
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abstract = "Introduction Previous reports describe lung malformations and other chest lesions in association with congenital diaphragmatic hernia (CDH), yet little is known how these lesions affect outcomes. We sought to evaluate the incidence and outcomes of patients diagnosed with chest lesions in association with CDH. Methods The charts of all infants treated for CDH in a single tertiary center from January 2004 to January 2015 were reviewed. The outcomes of those with space occupying lesions (SOLs) in association with CDH were compared to those with isolated CDH. Statistical analysis was performed using Student's t-test and Mann-Whitney U test for continuous variables and Fisher's exact for categorical variables. Results Of the 214 infants treated, 20 had an associated SOL (4 had > 1 lesion). SOLs were confirmed by pathological examination and included: bronchopulmonary sequestration (n = 10; 4.7{\%}), ectopic liver (n = 9; 4.2{\%}), foregut duplication cyst (n = 2; 1{\%}), and other lesions (n = 3; 1.4{\%}). No statistical difference was noted in the long-term outcomes of patients with SOL in comparison to those with isolated CDH. Conclusion SOLs are not uncommon in neonates with CDH. Despite theoretical concerns, there is no evidence that SOLs are associated with worse outcomes, a finding which is helpful during prenatal counseling of families.",
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