Sp1 and its likes

Biochemical and functional predictions for a growing family of zinc finger transcription factors

Tiffany Cook, Brian Gebelein, Raul Urrutia

Research output: Contribution to journalArticle

113 Citations (Scopus)

Abstract

The discovery and functional characterization of Sp1 as a GC-rich binding zinc finger protein provided a useful paradigm for understanding mechanisms mediating transcriptional activation in eukaryotic cells. This early paradigm suggested that promoters carrying GC-rich sequences are activated by Sp1 through its interaction with proteins from the basal transcriptional machinery to upregulate gene expression. Since the time of this seminal work, studies from several laboratories have led to the discovery of many Sp1-like transcription factors containing highly homologous DNA binding motifs that bind to similar sequences. Consequently, this knowledge poses many important questions regarding whether these related proteins have similar or antagonistic biochemical and functional properties to Sp1. The goal of this article is to use available database information and recent experimental evidence to describe the current repertoire of Sp1-like zinc finger transcription factors in mammalian cells. Furthermore, we discuss structural and functional studies that reveal that these proteins may share a role in morphogenetic pathways. Altogether, this information is aimed at better understanding how this growing family of transcription factors work to regulate gene expression and morphogenesis.

Original languageEnglish (US)
Pages (from-to)94-102
Number of pages9
JournalAnnals of the New York Academy of Sciences
Volume880
DOIs
StatePublished - 1999

Fingerprint

Zinc Fingers
Zinc
Transcription Factors
Gene expression
GC Rich Sequence
Sp1 Transcription Factor
Gene Expression
Nucleotide Motifs
Proteins
Eukaryotic Cells
Morphogenesis
Transcriptional Activation
Up-Regulation
Databases
Machinery
Chemical activation
Cells
Prediction
Protein
Transcription

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Sp1 and its likes : Biochemical and functional predictions for a growing family of zinc finger transcription factors. / Cook, Tiffany; Gebelein, Brian; Urrutia, Raul.

In: Annals of the New York Academy of Sciences, Vol. 880, 1999, p. 94-102.

Research output: Contribution to journalArticle

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