SOX2 Determines Lineage Restriction: Modeling Lung Squamous Cell Carcinoma in the Mouse

Research output: Contribution to journalShort survey

7 Scopus citations

Abstract

In this issue of Cancer Cell, Ferone et al. demonstrate that SOX2 not only drives lung tumor formation but also restricts tumor lineage to squamous cell carcinoma (LSCC), regardless of cell of origin. This novel LSCC model should facilitate identification of key oncogenic drivers and treatment strategies for this lung cancer subtype.

Original languageEnglish (US)
Pages (from-to)505-507
Number of pages3
JournalCancer Cell
Volume30
Issue number4
DOIs
StatePublished - Oct 10 2016

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

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