SOX11 expression is highly specific for mantle cell lymphoma and identifies the cyclin D1-negative subtype

Ana Mozos, Cristina Royo, Elena Hartmann, Daphne De Jong, Cristina Baró, Alexandra Valera, Kai Fu, Dennis D. Weisenburger, Jan Delabie, Shih Sung Chuang, Elaine S. Jaffe, Carmen Ruiz-Marcellan, Sandeep Dave, Lisa Rimsza, Rita Braziel, Randy D. Gascoyne, Francisco Solé, Armando López-Guillermo, Dolors Colomer, Louis M. StaudtAndreas Rosenwald, German Ott, Pedro Jares, Elias Campo

Research output: Contribution to journalArticle

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Abstract

Background: Cyclin D1-negative mantle cell lymphoma is difficult to distinguish from other small B-cell lymphomas. The clinical and pathological characteristics of patients with this form of lymphoma have not been well defined. Overexpression of the transcription factor SOX11 has been observed in conventional mantle cell lymphoma. The aim of this study was to determine whether this gene is expressed in cyclin D1-negative mantle cell lymphoma and whether its detection may be useful to identify these tumors. Design and Methods: The microarray database of 238 mature B-cell neoplasms was re-examined. SOX11 protein expression was investigated immunohistochemically in 12 cases of cyclin D1-negative mantle cell lymphoma, 54 cases of conventional mantle cell lymphoma, and 209 additional lymphoid neoplasms. Results: SOX11 mRNA was highly expressed in conventional and cyclin D1-negative mantle cell lymphoma and in 33% of the cases of Burkitt's lymphoma but not in any other mature lymphoid neoplasm. SOX11 nuclear protein was detected in 50 cases (93%) of conventional mantle cell lymphoma and also in the 12 cyclin D1-negative cases of mantle cell lymphoma, the six cases of lymphoblastic lymphomas, in two of eight cases of Burkitt's lymphoma, and in two of three T-prolymphocytic leukemias but was negative in the remaining lymphoid neoplasms. Cyclin D2 and D3 mRNA levels were significantly higher in cyclin D1-negative mantle cell lymphoma than in conventional mantle cell lymphoma but the protein expression was not discriminative. The clinico-pathological features and outcomes of the patients with cyclin D1-negative mantle cell lymphoma identified by SOX11 expression were similar to those of patients with conventional mantle cell lymphoma. Conclusions: SOX11 mRNA and nuclear protein expression is a highly specific marker for both cyclin D1-positive and negative mantle cell lymphoma.

Original languageEnglish (US)
Pages (from-to)1555-1562
Number of pages8
JournalHaematologica
Volume94
Issue number11
DOIs
StatePublished - Nov 2009
Externally publishedYes

Fingerprint

Mantle-Cell Lymphoma
Cyclin D1
Burkitt Lymphoma
Neoplasms
Nuclear Proteins
SOXC Transcription Factors
Messenger RNA
Prolymphocytic Leukemia
Cyclin D3
Cyclin D2
B-Cell Lymphoma
B-Cell Chronic Lymphocytic Leukemia
Precursor Cell Lymphoblastic Leukemia-Lymphoma

Keywords

  • Cyclin D1
  • Mantle cell lymphoma
  • SOX11

ASJC Scopus subject areas

  • Hematology

Cite this

Mozos, A., Royo, C., Hartmann, E., De Jong, D., Baró, C., Valera, A., ... Campo, E. (2009). SOX11 expression is highly specific for mantle cell lymphoma and identifies the cyclin D1-negative subtype. Haematologica, 94(11), 1555-1562. https://doi.org/10.3324/haematol.2009.010264

SOX11 expression is highly specific for mantle cell lymphoma and identifies the cyclin D1-negative subtype. / Mozos, Ana; Royo, Cristina; Hartmann, Elena; De Jong, Daphne; Baró, Cristina; Valera, Alexandra; Fu, Kai; Weisenburger, Dennis D.; Delabie, Jan; Chuang, Shih Sung; Jaffe, Elaine S.; Ruiz-Marcellan, Carmen; Dave, Sandeep; Rimsza, Lisa; Braziel, Rita; Gascoyne, Randy D.; Solé, Francisco; López-Guillermo, Armando; Colomer, Dolors; Staudt, Louis M.; Rosenwald, Andreas; Ott, German; Jares, Pedro; Campo, Elias.

In: Haematologica, Vol. 94, No. 11, 11.2009, p. 1555-1562.

Research output: Contribution to journalArticle

Mozos, A, Royo, C, Hartmann, E, De Jong, D, Baró, C, Valera, A, Fu, K, Weisenburger, DD, Delabie, J, Chuang, SS, Jaffe, ES, Ruiz-Marcellan, C, Dave, S, Rimsza, L, Braziel, R, Gascoyne, RD, Solé, F, López-Guillermo, A, Colomer, D, Staudt, LM, Rosenwald, A, Ott, G, Jares, P & Campo, E 2009, 'SOX11 expression is highly specific for mantle cell lymphoma and identifies the cyclin D1-negative subtype', Haematologica, vol. 94, no. 11, pp. 1555-1562. https://doi.org/10.3324/haematol.2009.010264
Mozos, Ana ; Royo, Cristina ; Hartmann, Elena ; De Jong, Daphne ; Baró, Cristina ; Valera, Alexandra ; Fu, Kai ; Weisenburger, Dennis D. ; Delabie, Jan ; Chuang, Shih Sung ; Jaffe, Elaine S. ; Ruiz-Marcellan, Carmen ; Dave, Sandeep ; Rimsza, Lisa ; Braziel, Rita ; Gascoyne, Randy D. ; Solé, Francisco ; López-Guillermo, Armando ; Colomer, Dolors ; Staudt, Louis M. ; Rosenwald, Andreas ; Ott, German ; Jares, Pedro ; Campo, Elias. / SOX11 expression is highly specific for mantle cell lymphoma and identifies the cyclin D1-negative subtype. In: Haematologica. 2009 ; Vol. 94, No. 11. pp. 1555-1562.
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abstract = "Background: Cyclin D1-negative mantle cell lymphoma is difficult to distinguish from other small B-cell lymphomas. The clinical and pathological characteristics of patients with this form of lymphoma have not been well defined. Overexpression of the transcription factor SOX11 has been observed in conventional mantle cell lymphoma. The aim of this study was to determine whether this gene is expressed in cyclin D1-negative mantle cell lymphoma and whether its detection may be useful to identify these tumors. Design and Methods: The microarray database of 238 mature B-cell neoplasms was re-examined. SOX11 protein expression was investigated immunohistochemically in 12 cases of cyclin D1-negative mantle cell lymphoma, 54 cases of conventional mantle cell lymphoma, and 209 additional lymphoid neoplasms. Results: SOX11 mRNA was highly expressed in conventional and cyclin D1-negative mantle cell lymphoma and in 33{\%} of the cases of Burkitt's lymphoma but not in any other mature lymphoid neoplasm. SOX11 nuclear protein was detected in 50 cases (93{\%}) of conventional mantle cell lymphoma and also in the 12 cyclin D1-negative cases of mantle cell lymphoma, the six cases of lymphoblastic lymphomas, in two of eight cases of Burkitt's lymphoma, and in two of three T-prolymphocytic leukemias but was negative in the remaining lymphoid neoplasms. Cyclin D2 and D3 mRNA levels were significantly higher in cyclin D1-negative mantle cell lymphoma than in conventional mantle cell lymphoma but the protein expression was not discriminative. The clinico-pathological features and outcomes of the patients with cyclin D1-negative mantle cell lymphoma identified by SOX11 expression were similar to those of patients with conventional mantle cell lymphoma. Conclusions: SOX11 mRNA and nuclear protein expression is a highly specific marker for both cyclin D1-positive and negative mantle cell lymphoma.",
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T1 - SOX11 expression is highly specific for mantle cell lymphoma and identifies the cyclin D1-negative subtype

AU - Mozos, Ana

AU - Royo, Cristina

AU - Hartmann, Elena

AU - De Jong, Daphne

AU - Baró, Cristina

AU - Valera, Alexandra

AU - Fu, Kai

AU - Weisenburger, Dennis D.

AU - Delabie, Jan

AU - Chuang, Shih Sung

AU - Jaffe, Elaine S.

AU - Ruiz-Marcellan, Carmen

AU - Dave, Sandeep

AU - Rimsza, Lisa

AU - Braziel, Rita

AU - Gascoyne, Randy D.

AU - Solé, Francisco

AU - López-Guillermo, Armando

AU - Colomer, Dolors

AU - Staudt, Louis M.

AU - Rosenwald, Andreas

AU - Ott, German

AU - Jares, Pedro

AU - Campo, Elias

PY - 2009/11

Y1 - 2009/11

N2 - Background: Cyclin D1-negative mantle cell lymphoma is difficult to distinguish from other small B-cell lymphomas. The clinical and pathological characteristics of patients with this form of lymphoma have not been well defined. Overexpression of the transcription factor SOX11 has been observed in conventional mantle cell lymphoma. The aim of this study was to determine whether this gene is expressed in cyclin D1-negative mantle cell lymphoma and whether its detection may be useful to identify these tumors. Design and Methods: The microarray database of 238 mature B-cell neoplasms was re-examined. SOX11 protein expression was investigated immunohistochemically in 12 cases of cyclin D1-negative mantle cell lymphoma, 54 cases of conventional mantle cell lymphoma, and 209 additional lymphoid neoplasms. Results: SOX11 mRNA was highly expressed in conventional and cyclin D1-negative mantle cell lymphoma and in 33% of the cases of Burkitt's lymphoma but not in any other mature lymphoid neoplasm. SOX11 nuclear protein was detected in 50 cases (93%) of conventional mantle cell lymphoma and also in the 12 cyclin D1-negative cases of mantle cell lymphoma, the six cases of lymphoblastic lymphomas, in two of eight cases of Burkitt's lymphoma, and in two of three T-prolymphocytic leukemias but was negative in the remaining lymphoid neoplasms. Cyclin D2 and D3 mRNA levels were significantly higher in cyclin D1-negative mantle cell lymphoma than in conventional mantle cell lymphoma but the protein expression was not discriminative. The clinico-pathological features and outcomes of the patients with cyclin D1-negative mantle cell lymphoma identified by SOX11 expression were similar to those of patients with conventional mantle cell lymphoma. Conclusions: SOX11 mRNA and nuclear protein expression is a highly specific marker for both cyclin D1-positive and negative mantle cell lymphoma.

AB - Background: Cyclin D1-negative mantle cell lymphoma is difficult to distinguish from other small B-cell lymphomas. The clinical and pathological characteristics of patients with this form of lymphoma have not been well defined. Overexpression of the transcription factor SOX11 has been observed in conventional mantle cell lymphoma. The aim of this study was to determine whether this gene is expressed in cyclin D1-negative mantle cell lymphoma and whether its detection may be useful to identify these tumors. Design and Methods: The microarray database of 238 mature B-cell neoplasms was re-examined. SOX11 protein expression was investigated immunohistochemically in 12 cases of cyclin D1-negative mantle cell lymphoma, 54 cases of conventional mantle cell lymphoma, and 209 additional lymphoid neoplasms. Results: SOX11 mRNA was highly expressed in conventional and cyclin D1-negative mantle cell lymphoma and in 33% of the cases of Burkitt's lymphoma but not in any other mature lymphoid neoplasm. SOX11 nuclear protein was detected in 50 cases (93%) of conventional mantle cell lymphoma and also in the 12 cyclin D1-negative cases of mantle cell lymphoma, the six cases of lymphoblastic lymphomas, in two of eight cases of Burkitt's lymphoma, and in two of three T-prolymphocytic leukemias but was negative in the remaining lymphoid neoplasms. Cyclin D2 and D3 mRNA levels were significantly higher in cyclin D1-negative mantle cell lymphoma than in conventional mantle cell lymphoma but the protein expression was not discriminative. The clinico-pathological features and outcomes of the patients with cyclin D1-negative mantle cell lymphoma identified by SOX11 expression were similar to those of patients with conventional mantle cell lymphoma. Conclusions: SOX11 mRNA and nuclear protein expression is a highly specific marker for both cyclin D1-positive and negative mantle cell lymphoma.

KW - Cyclin D1

KW - Mantle cell lymphoma

KW - SOX11

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