Sonographic pulmonary response after tracheal occlusion in fetuses with severe isolated congenital diaphragmatic hernia

Ayssa Teles Abrao Trad, Ricardo Czeresnia, Eniola Ibirogba, Kavita Narang, Rodrigo Ruano

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To report the longitudinal lung growth and prognosis of fetuses with severe left sided congenital diaphragmatic hernia (CDH) treated with fetoscopic tracheal occlusion (FETO) in a single institution. Methods: Fetal lung size (observed-to-expected lung area to head circumference [o/e-LHR]) was measured in seven consecutive fetuses with isolated severe left-sided CDH who underwent FETO. Fetal lung growth was used to prognosticate survival and need for ECMO. Results: Seven consecutive fetuses had a FETO procedure in the timeframe of this study. A total of 44 longitudinal ultrasound were performed to evaluate lung development. FETO was performed at GA 28.5 ± 0.5 weeks. Five (71.4%) infants survived to one-year follow-up and ECMO was needed in three patients (42.8%). Fetal lung response was observed in all fetuses; mean o/e-LHR increased from 22.5% ± 1.4 before FETO to 44.4% ± 9.8 before delivery. Infants who survived had a higher percentage of fetal lung growth (21.8%) than those who died (8.25%). Conclusion: Our study supports the hypothesis that FETO promotes fetal lung growth in fetuses with severe left-sided CDH, and the fetal pulmonary response seems to be associated with improved outcomes after the procedure.

Original languageEnglish (US)
Pages (from-to)185-190
Number of pages6
JournalJournal of Clinical Ultrasound
Volume50
Issue number2
DOIs
StatePublished - Feb 2022

Keywords

  • congenital diaphragmatic hernia
  • fetal interventions
  • fetal lungs
  • fetal tracheal occlusion
  • prenatal diagnosis
  • pulmonary hypoplasia
  • ultrasound

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Fingerprint

Dive into the research topics of 'Sonographic pulmonary response after tracheal occlusion in fetuses with severe isolated congenital diaphragmatic hernia'. Together they form a unique fingerprint.

Cite this