Sonographic assessment of the severity and progression of autosomal dominant polycystic kidney disease: The Consortium of Renal Imaging Studies in Polycystic Kidney Disease (CRISP)

W. Charles O'Neill, Michelle L. Robbin, Kyongtae T. Bae, Jared J. Grantham, Arlene B. Chapman, Lisa M. Guay-Woodford, Vicente Torres, Bernard Francis King, Louis H. Wetzel, Paul A. Thompson, J. Philip Miller

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Background: The accuracy and precision of ultrasonography (US) in assessing the severity of autosomal dominant polycystic kidney disease (ADPKD) is unknown. Methods: US and magnetic resonance imaging (MRI) were performed at baseline and 1 year on 230 subjects with ADPKD. Ellipsoid volume was calculated from US length, width, and depth, and sequential transverse images were used to measure total and cystic volume directly. These were compared with MRI measurements of kidney volume and cystic volume. Results: Variability between different sonographers ranged from 18% to 42%. Correlations between US and MRI volume were 0.88 and 0.89. The SD of the discrepancy from MRI ranged from 21% to 33% and was unrelated to kidney size or body mass. Kidney length was the most reproducible measurement, and its correlation with MRI volume was 0.84. All patients with an US volume less than 700 cm3 had an MRI volume less than 1,000 cm3, and all patients with an US volume greater than 1,700 cm3 had an MRI volume greater than 1,000 cm3. Increases in volume after 1 year were 12% ± 36% for the ellipsoid method, 6% ± 29% for the direct method, and 4.2% ± 7.2% for MRI. Correlation between US and MRI measurement of fractional cyst volume was 0.80. Conclusion: Sonographic measurement of kidney volume in patients with ADPKD is inaccurate and lacks the precision necessary to measure short-term disease progression. However, sonography can provide an estimate of kidney volume that reflects severity and prognosis in individual patients.

Original languageEnglish (US)
Pages (from-to)1058-1064
Number of pages7
JournalAmerican Journal of Kidney Diseases
Volume46
Issue number6
DOIs
StatePublished - Dec 2005

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Autosomal Dominant Polycystic Kidney
Polycystic Kidney Diseases
Ultrasonography
Magnetic Resonance Imaging
Kidney
Cystic Kidney Diseases
Body Size
Disease Progression
Cysts

Keywords

  • Kidney volume
  • Magnetic resonance imaging
  • Ultrasonography

ASJC Scopus subject areas

  • Nephrology

Cite this

Sonographic assessment of the severity and progression of autosomal dominant polycystic kidney disease : The Consortium of Renal Imaging Studies in Polycystic Kidney Disease (CRISP). / O'Neill, W. Charles; Robbin, Michelle L.; Bae, Kyongtae T.; Grantham, Jared J.; Chapman, Arlene B.; Guay-Woodford, Lisa M.; Torres, Vicente; King, Bernard Francis; Wetzel, Louis H.; Thompson, Paul A.; Miller, J. Philip.

In: American Journal of Kidney Diseases, Vol. 46, No. 6, 12.2005, p. 1058-1064.

Research output: Contribution to journalArticle

O'Neill, W. Charles ; Robbin, Michelle L. ; Bae, Kyongtae T. ; Grantham, Jared J. ; Chapman, Arlene B. ; Guay-Woodford, Lisa M. ; Torres, Vicente ; King, Bernard Francis ; Wetzel, Louis H. ; Thompson, Paul A. ; Miller, J. Philip. / Sonographic assessment of the severity and progression of autosomal dominant polycystic kidney disease : The Consortium of Renal Imaging Studies in Polycystic Kidney Disease (CRISP). In: American Journal of Kidney Diseases. 2005 ; Vol. 46, No. 6. pp. 1058-1064.
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abstract = "Background: The accuracy and precision of ultrasonography (US) in assessing the severity of autosomal dominant polycystic kidney disease (ADPKD) is unknown. Methods: US and magnetic resonance imaging (MRI) were performed at baseline and 1 year on 230 subjects with ADPKD. Ellipsoid volume was calculated from US length, width, and depth, and sequential transverse images were used to measure total and cystic volume directly. These were compared with MRI measurements of kidney volume and cystic volume. Results: Variability between different sonographers ranged from 18{\%} to 42{\%}. Correlations between US and MRI volume were 0.88 and 0.89. The SD of the discrepancy from MRI ranged from 21{\%} to 33{\%} and was unrelated to kidney size or body mass. Kidney length was the most reproducible measurement, and its correlation with MRI volume was 0.84. All patients with an US volume less than 700 cm3 had an MRI volume less than 1,000 cm3, and all patients with an US volume greater than 1,700 cm3 had an MRI volume greater than 1,000 cm3. Increases in volume after 1 year were 12{\%} ± 36{\%} for the ellipsoid method, 6{\%} ± 29{\%} for the direct method, and 4.2{\%} ± 7.2{\%} for MRI. Correlation between US and MRI measurement of fractional cyst volume was 0.80. Conclusion: Sonographic measurement of kidney volume in patients with ADPKD is inaccurate and lacks the precision necessary to measure short-term disease progression. However, sonography can provide an estimate of kidney volume that reflects severity and prognosis in individual patients.",
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T1 - Sonographic assessment of the severity and progression of autosomal dominant polycystic kidney disease

T2 - The Consortium of Renal Imaging Studies in Polycystic Kidney Disease (CRISP)

AU - O'Neill, W. Charles

AU - Robbin, Michelle L.

AU - Bae, Kyongtae T.

AU - Grantham, Jared J.

AU - Chapman, Arlene B.

AU - Guay-Woodford, Lisa M.

AU - Torres, Vicente

AU - King, Bernard Francis

AU - Wetzel, Louis H.

AU - Thompson, Paul A.

AU - Miller, J. Philip

PY - 2005/12

Y1 - 2005/12

N2 - Background: The accuracy and precision of ultrasonography (US) in assessing the severity of autosomal dominant polycystic kidney disease (ADPKD) is unknown. Methods: US and magnetic resonance imaging (MRI) were performed at baseline and 1 year on 230 subjects with ADPKD. Ellipsoid volume was calculated from US length, width, and depth, and sequential transverse images were used to measure total and cystic volume directly. These were compared with MRI measurements of kidney volume and cystic volume. Results: Variability between different sonographers ranged from 18% to 42%. Correlations between US and MRI volume were 0.88 and 0.89. The SD of the discrepancy from MRI ranged from 21% to 33% and was unrelated to kidney size or body mass. Kidney length was the most reproducible measurement, and its correlation with MRI volume was 0.84. All patients with an US volume less than 700 cm3 had an MRI volume less than 1,000 cm3, and all patients with an US volume greater than 1,700 cm3 had an MRI volume greater than 1,000 cm3. Increases in volume after 1 year were 12% ± 36% for the ellipsoid method, 6% ± 29% for the direct method, and 4.2% ± 7.2% for MRI. Correlation between US and MRI measurement of fractional cyst volume was 0.80. Conclusion: Sonographic measurement of kidney volume in patients with ADPKD is inaccurate and lacks the precision necessary to measure short-term disease progression. However, sonography can provide an estimate of kidney volume that reflects severity and prognosis in individual patients.

AB - Background: The accuracy and precision of ultrasonography (US) in assessing the severity of autosomal dominant polycystic kidney disease (ADPKD) is unknown. Methods: US and magnetic resonance imaging (MRI) were performed at baseline and 1 year on 230 subjects with ADPKD. Ellipsoid volume was calculated from US length, width, and depth, and sequential transverse images were used to measure total and cystic volume directly. These were compared with MRI measurements of kidney volume and cystic volume. Results: Variability between different sonographers ranged from 18% to 42%. Correlations between US and MRI volume were 0.88 and 0.89. The SD of the discrepancy from MRI ranged from 21% to 33% and was unrelated to kidney size or body mass. Kidney length was the most reproducible measurement, and its correlation with MRI volume was 0.84. All patients with an US volume less than 700 cm3 had an MRI volume less than 1,000 cm3, and all patients with an US volume greater than 1,700 cm3 had an MRI volume greater than 1,000 cm3. Increases in volume after 1 year were 12% ± 36% for the ellipsoid method, 6% ± 29% for the direct method, and 4.2% ± 7.2% for MRI. Correlation between US and MRI measurement of fractional cyst volume was 0.80. Conclusion: Sonographic measurement of kidney volume in patients with ADPKD is inaccurate and lacks the precision necessary to measure short-term disease progression. However, sonography can provide an estimate of kidney volume that reflects severity and prognosis in individual patients.

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KW - Magnetic resonance imaging

KW - Ultrasonography

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