Some clinical and pathologic observations on chronic myelopathy: a variant of multiple sclerosis

B. G. Weinshenker, J. J. Gilbert, G. C. Ebers

Research output: Contribution to journalArticle

11 Scopus citations


Four patients with progressive demyelinating myelopathy with symptons spanning six to 25 years are described. There was no clinical evidence of dissemination of lesions in the central nervous system. Radiological evidence of dissemination was present in two cases; in one this was absent at the time of presentation and was only demonstrated after six years of progressive unifocal disease. In one case, pathological examination revealed a solitary area of chronic demyelination. In all cases but one, oligoclonal bands were detected on cerebrospinal fluid (CSF) electrophoresis. Some cases of chronically progressive myelopathy result from focal demyelination in the absence of a second lesion demonstrable by clinical, radiographic or necropsy examination.

Original languageEnglish (US)
Pages (from-to)146-149
Number of pages4
JournalJournal of Neurology Neurosurgery and Psychiatry
Issue number2
StatePublished - Jan 1 1990


ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology
  • Psychiatry and Mental health

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