Somatotropic and gonadotropic axes linkages in infancy, childhood, and the puberty-adult transition

Johannes D. Veldhuis, James N. Roemmich, Erick J. Richmond, Cyril Y. Bowers

Research output: Contribution to journalReview article

171 Scopus citations

Abstract

Integrative neuroendocrine control of the gonadotropic and somatotropic axes in childhood, puberty, and young adulthood proceeds via multiple convergent and divergent pathways in the human and experimental animal. Emerging ensemble concepts are required to embody independent, parallel, and interacting mechanisms that subserve physiological adaptations and pathological disruption of reproduction and growth. Significant advances in systems biology will be needed to address these challenges.

Original languageEnglish (US)
Pages (from-to)101-140
Number of pages40
JournalEndocrine reviews
Volume27
Issue number2
DOIs
StatePublished - Apr 2006

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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