TY - JOUR
T1 - Somatic copy number gains in MYC, BCL2, and BCL6 identifies a subset of aggressive alternative-DH/TH DLBCL patients
AU - Krull, Jordan E.
AU - Wenzl, Kerstin
AU - Hartert, Keenan T.
AU - Manske, Michelle K.
AU - Sarangi, Vivekananda
AU - Maurer, Matthew J.
AU - Larson, Melissa C.
AU - Nowakowski, Grzegorz S.
AU - Ansell, Stephen M.
AU - McPhail, Ellen
AU - Habermann, Thomas M.
AU - Link, Brian K.
AU - King, Rebecca L.
AU - Cerhan, James R.
AU - Novak, Anne J.
N1 - Funding Information:
This work was supported in part by the National Institutes of Health (P50 CA097274 to J.R.C. and A.J.N.; R01 CA212162 to A.J.N. and J.R.C.; U01 CA195568 to J.R.C.; T32 AI007425-24 to J.E.K.). We would like to thank Dr. Patty Greipp, Darlene Knutson, Sara Kloft-Nelson, and Ryan Knudson in Mayo Cytogenetics Core for help with the FISH and OncoScan studies.
Publisher Copyright:
© 2020, The Author(s).
PY - 2020/11
Y1 - 2020/11
N2 - Double/triple hit lymphoma (DH/TH), known as high-grade B-cell lymphoma (HGBL), is an aggressive diffuse large B cell lymphoma (DLBCL), defined as having concurrent MYC, BCL2, and/or BCL6 gene rearrangements. While gene rearrangements represent significant genetic events in cancer, copy number alterations (CNAs) also play an important role, and their contributions to rearrangements have yet to be fully elucidated. Using FISH and high-resolution CNA data, we defined the landscape of concurrent gene rearrangements and copy gains in MYC, BCL2, and BCL6, in a cohort of 479 newly diagnosed DLBCL. We also show that concurrent translocations and copy number alterations, in combinations similar to DH/TH, identify a unique subset of DLBCL, alternative DH/TH, that have survival outcomes similar to DH/TH DLBCL patients.
AB - Double/triple hit lymphoma (DH/TH), known as high-grade B-cell lymphoma (HGBL), is an aggressive diffuse large B cell lymphoma (DLBCL), defined as having concurrent MYC, BCL2, and/or BCL6 gene rearrangements. While gene rearrangements represent significant genetic events in cancer, copy number alterations (CNAs) also play an important role, and their contributions to rearrangements have yet to be fully elucidated. Using FISH and high-resolution CNA data, we defined the landscape of concurrent gene rearrangements and copy gains in MYC, BCL2, and BCL6, in a cohort of 479 newly diagnosed DLBCL. We also show that concurrent translocations and copy number alterations, in combinations similar to DH/TH, identify a unique subset of DLBCL, alternative DH/TH, that have survival outcomes similar to DH/TH DLBCL patients.
UR - http://www.scopus.com/inward/record.url?scp=85095703178&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85095703178&partnerID=8YFLogxK
U2 - 10.1038/s41408-020-00382-3
DO - 10.1038/s41408-020-00382-3
M3 - Article
C2 - 33168821
AN - SCOPUS:85095703178
SN - 2044-5385
VL - 10
JO - Blood Cancer Journal
JF - Blood Cancer Journal
IS - 11
M1 - 117
ER -