Somatic cell mapping of T-cell receptor CD3 complex and CD8 genes in cattle

Lei Li, Alan Teale, Albert Bensaid, Sabrina Dunlap, Allan B. Dietz, James E. Womack

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Bovine genes encoding T-cell receptor, CD3, and CD8 molecules have been mapped to syntetic groups using bovine × rodent hybrid somatic cells. T-cell receptor α and δ chains were assigned to bovine syntenic group U5, and the β and γ genes were syntenic with each other and with markers on U13. CD3E and CD3D genes were syntenic with each other and located to bovine syntenic group U19. CD8 was most concordant with markers of syntenic group U16, although the concordancy was only 85% and the assignment must be regarded as tentative. The comparative gene maps of human chromosome 7, bovine syntenic group U13, and mouse chromosomes 6 and 13 suggest extensive evolutionary conservation.

Original languageEnglish (US)
Pages (from-to)224-229
Number of pages6
JournalImmunogenetics
Volume36
Issue number4
DOIs
StatePublished - Jul 1 1992

ASJC Scopus subject areas

  • Immunology
  • Genetics

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