Solute transport in cyclically deformed porous tissue scaffolds with controlled pore cross-sectional geometries

Jorn Op Den Buijs, Lichun Lu, Steven M. Jorgensen, M. (Dan) Dragomir Daescu, Michael J Yaszemski, Erik L. Ritman

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The objective of this study was to investigate the influence of pore geometry on the transport rate and depth after repetitive mechanical deformation of porous scaffolds for tissue engineering applications. Flexible cubic imaging phantoms with pores in the shape of a circular cylinder, elliptic cylinder, and spheroid were fabricated from a biodegradable polymer blend using a combined 3D printing and injection molding technique. The specimens were immersed in fluid and loaded with a solution of a radiopaque solute. The solute distribution was quantified by recording 20μm pixel-resolution images in an X-ray microimaging scanner at selected time points after intervals of dynamic straining with a mean strain of 8.6±1.6% at 1.0Hz. The results show that application of cyclic strain significantly increases the rate and depth of solute transport, as compared to diffusive transport alone, for all pore shapes. In addition, pore shape, pore size, and the orientation of the pore cross-sectional asymmetry with respect to the direction of strain greatly influence solute transport. Thus, pore geometry can be tailored to increase transport rates and depths in cyclically deformed scaffolds, which is of utmost importance when thick, metabolically functional tissues are to be engineered.

Original languageEnglish (US)
Pages (from-to)1989-1999
Number of pages11
JournalTissue Engineering - Part A
Volume15
Issue number8
DOIs
StatePublished - Aug 1 2009

Fingerprint

Imaging Phantoms
Tissue Scaffolds
Solute transport
Tissue Engineering
Polymers
X-Rays
Injections
Geometry
Biodegradable polymers
Polymer blends
Scaffolds (biology)
Circular cylinders
Image resolution
Tissue engineering
Injection molding
Scaffolds
Pore size
Printing
Pixels
Tissue

ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • Biomedical Engineering
  • Biomaterials

Cite this

Solute transport in cyclically deformed porous tissue scaffolds with controlled pore cross-sectional geometries. / Op Den Buijs, Jorn; Lu, Lichun; Jorgensen, Steven M.; Dragomir Daescu, M. (Dan); Yaszemski, Michael J; Ritman, Erik L.

In: Tissue Engineering - Part A, Vol. 15, No. 8, 01.08.2009, p. 1989-1999.

Research output: Contribution to journalArticle

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