Soluble urinary somatic angiotensin converting enzyme is overexpressed in patients with preeclampsia: a potential new marker for the disease?

Fernando Sontag; Sonja Suvakov; Vesna D. Garovic

doi:10.1080/10641955.2022.2115060

Soluble urinary somatic angiotensin converting enzyme is overexpressed in patients with preeclampsia: a potential new marker for the disease?

Fernando Sontag, Sonja Suvakov, Vesna D. Garovic

Nephrology and Hypertension

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: The aim of this study was to identify and quantify urinary Angiotensin-Converting-Enzyme (ACE) in hypertensive disorders of pregnancy. Methods: Urine samples were analyzed by Western blot. Patients were classified into: normotensive pregnancy (N); preeclampsia and superimposed preeclampsia (PE+SPE); and gestational hypertension (GH). Results: Somatic ACE protein expression was higher in PE+SPE compared to N and GH. There was a positive correlation between ACE and urinary protein to creatinine ratio, systolic and diastolic blood pressures. Conclusion: These results indicate ACE overexpression in the urine of preeclamptic patients and suggest that it may be a new marker for the disease.

Original language	English (US)
Pages (from-to)	190-197
Number of pages	8
Journal	Hypertension in Pregnancy
Volume	41
Issue number	3-4
DOIs	https://doi.org/10.1080/10641955.2022.2115060
State	Published - 2022

Keywords

Preeclampsia
angiotensin converting enzyme
hypertensive pregnancy disorder
renin angiotensin aldosterone system

ASJC Scopus subject areas

Internal Medicine
Obstetrics and Gynecology

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10.1080/10641955.2022.2115060

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title = "Soluble urinary somatic angiotensin converting enzyme is overexpressed in patients with preeclampsia: a potential new marker for the disease?",

abstract = "Objective: The aim of this study was to identify and quantify urinary Angiotensin-Converting-Enzyme (ACE) in hypertensive disorders of pregnancy. Methods: Urine samples were analyzed by Western blot. Patients were classified into: normotensive pregnancy (N); preeclampsia and superimposed preeclampsia (PE+SPE); and gestational hypertension (GH). Results: Somatic ACE protein expression was higher in PE+SPE compared to N and GH. There was a positive correlation between ACE and urinary protein to creatinine ratio, systolic and diastolic blood pressures. Conclusion: These results indicate ACE overexpression in the urine of preeclamptic patients and suggest that it may be a new marker for the disease.",

keywords = "Preeclampsia, angiotensin converting enzyme, hypertensive pregnancy disorder, renin angiotensin aldosterone system",

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language = "English (US)",

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T1 - Soluble urinary somatic angiotensin converting enzyme is overexpressed in patients with preeclampsia

T2 - a potential new marker for the disease?

AU - Sontag, Fernando

AU - Suvakov, Sonja

AU - Garovic, Vesna D.

PY - 2022

Y1 - 2022

N2 - Objective: The aim of this study was to identify and quantify urinary Angiotensin-Converting-Enzyme (ACE) in hypertensive disorders of pregnancy. Methods: Urine samples were analyzed by Western blot. Patients were classified into: normotensive pregnancy (N); preeclampsia and superimposed preeclampsia (PE+SPE); and gestational hypertension (GH). Results: Somatic ACE protein expression was higher in PE+SPE compared to N and GH. There was a positive correlation between ACE and urinary protein to creatinine ratio, systolic and diastolic blood pressures. Conclusion: These results indicate ACE overexpression in the urine of preeclamptic patients and suggest that it may be a new marker for the disease.

AB - Objective: The aim of this study was to identify and quantify urinary Angiotensin-Converting-Enzyme (ACE) in hypertensive disorders of pregnancy. Methods: Urine samples were analyzed by Western blot. Patients were classified into: normotensive pregnancy (N); preeclampsia and superimposed preeclampsia (PE+SPE); and gestational hypertension (GH). Results: Somatic ACE protein expression was higher in PE+SPE compared to N and GH. There was a positive correlation between ACE and urinary protein to creatinine ratio, systolic and diastolic blood pressures. Conclusion: These results indicate ACE overexpression in the urine of preeclamptic patients and suggest that it may be a new marker for the disease.

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KW - angiotensin converting enzyme

KW - hypertensive pregnancy disorder

KW - renin angiotensin aldosterone system

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Soluble urinary somatic angiotensin converting enzyme is overexpressed in patients with preeclampsia: a potential new marker for the disease?

Abstract

Keywords

ASJC Scopus subject areas

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