Soluble urinary somatic angiotensin converting enzyme is overexpressed in patients with preeclampsia: a potential new marker for the disease?

Fernando Sontag, Sonja Suvakov, Vesna D. Garovic

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: The aim of this study was to identify and quantify urinary Angiotensin-Converting-Enzyme (ACE) in hypertensive disorders of pregnancy. Methods: Urine samples were analyzed by Western blot. Patients were classified into: normotensive pregnancy (N); preeclampsia and superimposed preeclampsia (PE+SPE); and gestational hypertension (GH). Results: Somatic ACE protein expression was higher in PE+SPE compared to N and GH. There was a positive correlation between ACE and urinary protein to creatinine ratio, systolic and diastolic blood pressures. Conclusion: These results indicate ACE overexpression in the urine of preeclamptic patients and suggest that it may be a new marker for the disease.

Original languageEnglish (US)
JournalHypertension in Pregnancy
DOIs
StateAccepted/In press - 2022

Keywords

  • angiotensin converting enzyme
  • hypertensive pregnancy disorder
  • Preeclampsia
  • renin angiotensin aldosterone system

ASJC Scopus subject areas

  • Internal Medicine
  • Obstetrics and Gynecology

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