Soluble B7-H1: Differences in production between dendritic cells and T cells

Xavier Frigola, Brant A. Inman, Christopher J. Krco, Xin Liu, Susan M. Harrington, Peggy A. Bulur, Allan B Dietz, Haidong M Dong, Eugene D Kwon

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Tumor cells aberrantly express several T cell inhibitory molecules including members of the B7-H co-regulatory family. Presumably tumor-expressed B7-H1 and B7-H3 confer resistance to elimination by the immune system. In addition, elevated levels of soluble B7-H1 (sB7-H1) has been identified in the sera of cancer patients, including renal carcinoma patients and is associated with increased cancer related death. Here we report that sB7-H1 is produced and released by activated mature dendritic cells (mDC). Immature DC, macrophages, monocytes, or T cells are refractory to releasing sB7-H1. Exposure of CD4+ and CD8+ T cells to mDC-derived sB7-H1 molecules induced apoptosis. These data suggest that the immunobiology of B7-H1 is perhaps more complex than previously thought. sB7-H1 molecules may represent an unanticipated contributing factor to immune homeostasis. That both immune and tumor cells can be sources of sB7-H1 suggests that optimization of co-regulatory blockade immunotherapy for solid malignancies of necessity will require impact of targeting tumor and immune-derived B7-H1 molecules.

Original languageEnglish (US)
Pages (from-to)78-82
Number of pages5
JournalImmunology Letters
Volume142
Issue number1-2
DOIs
StatePublished - Feb 29 2012

Fingerprint

Dendritic Cells
T-Lymphocytes
B7 Antigens
Neoplasms
Immunologic Factors
Immunotherapy
Monocytes
Immune System
Homeostasis
Macrophages
Apoptosis
Carcinoma
Kidney
Serum

Keywords

  • B7-H1
  • Coregulatory
  • Dendritic cell
  • Soluble
  • T cell
  • Tumor cell

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Frigola, X., Inman, B. A., Krco, C. J., Liu, X., Harrington, S. M., Bulur, P. A., ... Kwon, E. D. (2012). Soluble B7-H1: Differences in production between dendritic cells and T cells. Immunology Letters, 142(1-2), 78-82. https://doi.org/10.1016/j.imlet.2011.11.001

Soluble B7-H1 : Differences in production between dendritic cells and T cells. / Frigola, Xavier; Inman, Brant A.; Krco, Christopher J.; Liu, Xin; Harrington, Susan M.; Bulur, Peggy A.; Dietz, Allan B; Dong, Haidong M; Kwon, Eugene D.

In: Immunology Letters, Vol. 142, No. 1-2, 29.02.2012, p. 78-82.

Research output: Contribution to journalArticle

Frigola X, Inman BA, Krco CJ, Liu X, Harrington SM, Bulur PA et al. Soluble B7-H1: Differences in production between dendritic cells and T cells. Immunology Letters. 2012 Feb 29;142(1-2):78-82. https://doi.org/10.1016/j.imlet.2011.11.001
Frigola, Xavier ; Inman, Brant A. ; Krco, Christopher J. ; Liu, Xin ; Harrington, Susan M. ; Bulur, Peggy A. ; Dietz, Allan B ; Dong, Haidong M ; Kwon, Eugene D. / Soluble B7-H1 : Differences in production between dendritic cells and T cells. In: Immunology Letters. 2012 ; Vol. 142, No. 1-2. pp. 78-82.
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