Soluble B7-H1: Differences in production between dendritic cells and T cells

Xavier Frigola, Brant A. Inman, Christopher J. Krco, Xin Liu, Susan M. Harrington, Peggy A. Bulur, Allan B. Dietz, Haidong Dong, Eugene D. Kwon

Research output: Contribution to journalLetter

53 Scopus citations

Abstract

Tumor cells aberrantly express several T cell inhibitory molecules including members of the B7-H co-regulatory family. Presumably tumor-expressed B7-H1 and B7-H3 confer resistance to elimination by the immune system. In addition, elevated levels of soluble B7-H1 (sB7-H1) has been identified in the sera of cancer patients, including renal carcinoma patients and is associated with increased cancer related death. Here we report that sB7-H1 is produced and released by activated mature dendritic cells (mDC). Immature DC, macrophages, monocytes, or T cells are refractory to releasing sB7-H1. Exposure of CD4+ and CD8+ T cells to mDC-derived sB7-H1 molecules induced apoptosis. These data suggest that the immunobiology of B7-H1 is perhaps more complex than previously thought. sB7-H1 molecules may represent an unanticipated contributing factor to immune homeostasis. That both immune and tumor cells can be sources of sB7-H1 suggests that optimization of co-regulatory blockade immunotherapy for solid malignancies of necessity will require impact of targeting tumor and immune-derived B7-H1 molecules.

Original languageEnglish (US)
Pages (from-to)78-82
Number of pages5
JournalImmunology Letters
Volume142
Issue number1-2
DOIs
StatePublished - Feb 29 2012

Keywords

  • B7-H1
  • Coregulatory
  • Dendritic cell
  • Soluble
  • T cell
  • Tumor cell

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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