TY - JOUR
T1 - Solid Organ Transplantation From SARS-CoV-2- infected Donors to Uninfected Recipients
T2 - A Single-center Experience
AU - Jayasekera, Channa R.
AU - Vikram, Holenarasipur R.
AU - Rifat, Zeeshan
AU - Wagler, Josiah
AU - Okubo, Keita
AU - Braaksma, Brandon R.
AU - Harbell, Jack W.
AU - Jadlowiec, Caroline C.
AU - Katariya, Nitin N.
AU - Mathur, Amit K.
AU - Moss, Adyr
AU - Sudhakar Reddy, K.
AU - Singer, Andrew
AU - Orenstein, Robert
AU - Saling, Christopher F.
AU - Seville, Maria T.
AU - Mour, Girish K.
AU - Vargas, Hugo E.
AU - Byrne, Thomas J.
AU - Hewitt, Winston R.
AU - Aqel, Bashar A.
N1 - Publisher Copyright:
© 2022 Wolters Kluwer Health. All rights reserved.
PY - 2022/1/13
Y1 - 2022/1/13
N2 - Background. The risk of donor-derived severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in solid organ (heart, lung, liver, kidney, pancreas, and intestine) transplant recipients is poorly understood. Since hematogenous transmission of SARS-CoV-2 has not been documented to date, nonlung solid organs might be suitable for transplantation since they likely portend a low risk of viral transmission. Methods. Abdominal solid organs from SARS-CoV-2-infected donors were transplanted into uninfected recipients. Results. Between April 18, 2021, and October 30, 2021, we performed transplants of 2 livers, 1 simultaneous liver and kidney, 1 kidney, and 1 simultaneous kidney and pancreas from SARS-CoV-2- infected donors into 5 uninfected recipients. None of the recipients developed SARS-CoV-2 infection or coronavirus disease 2019, and when tested, allograft biopsies showed no evidence of SARS-CoV-2 RNA. Conclusions. Transplanting nonlung organs from SARS-CoV-2-infected donors into uninfected recipients demonstrated no evidence of virus transmission.
AB - Background. The risk of donor-derived severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in solid organ (heart, lung, liver, kidney, pancreas, and intestine) transplant recipients is poorly understood. Since hematogenous transmission of SARS-CoV-2 has not been documented to date, nonlung solid organs might be suitable for transplantation since they likely portend a low risk of viral transmission. Methods. Abdominal solid organs from SARS-CoV-2-infected donors were transplanted into uninfected recipients. Results. Between April 18, 2021, and October 30, 2021, we performed transplants of 2 livers, 1 simultaneous liver and kidney, 1 kidney, and 1 simultaneous kidney and pancreas from SARS-CoV-2- infected donors into 5 uninfected recipients. None of the recipients developed SARS-CoV-2 infection or coronavirus disease 2019, and when tested, allograft biopsies showed no evidence of SARS-CoV-2 RNA. Conclusions. Transplanting nonlung organs from SARS-CoV-2-infected donors into uninfected recipients demonstrated no evidence of virus transmission.
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U2 - 10.1097/TXD.0000000000001286
DO - 10.1097/TXD.0000000000001286
M3 - Article
AN - SCOPUS:85123982274
SN - 2373-8731
VL - 8
SP - E1286
JO - Transplantation Direct
JF - Transplantation Direct
IS - 2
ER -