Solar insolation in springtime influences age of onset of bipolar I disorder

M. Bauer, T. Glenn, M. Alda, M. A. Aleksandrovich, O. A. Andreassen, E. Angelopoulos, R. Ardau, Y. Ayhan, C. Baethge, S. R. Bharathram, R. Bauer, B. T. Baune, C. Becerra-Palars, F. Bellivier, R. H. Belmaker, M. Berk, Y. Bersudsky, Bicakci, H. Birabwa-Oketcho, T. D. BjellaL. Bossini, J. Cabrera, E. Y.W. Cheung, M. Del Zompo, S. Dodd, M. Donix, B. Etain, A. Fagiolini, K. N. Fountoulakis, Mark A Frye, A. Gonzalez-Pinto, J. F. Gottlieb, P. Grof, H. Harima, C. Henry, E. T. Isometsä, S. Janno, F. Kapczinski, M. Kardell, S. Khaldi, S. Kliwicki, B. König, T. L. Kot, R. Krogh, M. Kunz, B. Lafer, M. Landén, E. R. Larsen, U. Lewitzka, R. W. Licht, C. Lopez-Jaramillo, G. MacQueen, M. Manchia, W. Marsh, M. Martinez-Cengotitabengoa, I. Melle, F. Meza-Urzúa, M. Yee Ming, S. Monteith, G. Morken, E. Mosca, R. Munoz, S. V. Mythri, F. Nacef, R. K. Nadella, F. G. Nery, R. E. Nielsen, C. O'Donovan, A. Omrani, Y. Osher, H. Østermark Sørensen, U. Ouali, Y. Pica Ruiz, M. Pilhatsch, M. Pinna, F. D.R. da Ponte, D. Quiroz, R. Ramesar, N. Rasgon, M. S. Reddy, A. Reif, P. Ritter, J. K. Rybakowski, K. Sagduyu, M. Scippa, E. Severus, C. Simhandl, D. J. Stein, S. Strejilevich, M. Subramaniam, A. H. Sulaiman, K. Suominen, H. Tagata, Y. Tatebayashi, L. Tondo, C. Torrent, A. E. Vaaler, J. Veeh, E. Vieta, B. Viswanath, M. Yoldi-Negrete, M. Zetin, Y. Zgueb, P. C. Whybrow

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Objective: To confirm prior findings that the larger the maximum monthly increase in solar insolation in springtime, the younger the age of onset of bipolar disorder. Method: Data were collected from 5536 patients at 50 sites in 32 countries on six continents. Onset occurred at 456 locations in 57 countries. Variables included solar insolation, birth-cohort, family history, polarity of first episode and country physician density. Results: There was a significant, inverse association between the maximum monthly increase in solar insolation at the onset location, and the age of onset. This effect was reduced in those without a family history of mood disorders and with a first episode of mania rather than depression. The maximum monthly increase occurred in springtime. The youngest birth-cohort had the youngest age of onset. All prior relationships were confirmed using both the entire sample, and only the youngest birth-cohort (all estimated coefficients P < 0.001). Conclusion: A large increase in springtime solar insolation may impact the onset of bipolar disorder, especially with a family history of mood disorders. Recent societal changes that affect light exposure (LED lighting, mobile devices backlit with LEDs) may influence adaptability to a springtime circadian challenge.

Original languageEnglish (US)
Pages (from-to)571-582
Number of pages12
JournalActa Psychiatrica Scandinavica
Volume136
Issue number6
DOIs
StatePublished - Dec 1 2017

Fingerprint

Bipolar Disorder
Age of Onset
Parturition
Mood Disorders
Lighting
Depression
Physicians
Light
Equipment and Supplies

Keywords

  • bipolar disorder
  • circadian rhythm
  • epidemiology
  • solar insolation

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Bauer, M., Glenn, T., Alda, M., Aleksandrovich, M. A., Andreassen, O. A., Angelopoulos, E., ... Whybrow, P. C. (2017). Solar insolation in springtime influences age of onset of bipolar I disorder. Acta Psychiatrica Scandinavica, 136(6), 571-582. https://doi.org/10.1111/acps.12772

Solar insolation in springtime influences age of onset of bipolar I disorder. / Bauer, M.; Glenn, T.; Alda, M.; Aleksandrovich, M. A.; Andreassen, O. A.; Angelopoulos, E.; Ardau, R.; Ayhan, Y.; Baethge, C.; Bharathram, S. R.; Bauer, R.; Baune, B. T.; Becerra-Palars, C.; Bellivier, F.; Belmaker, R. H.; Berk, M.; Bersudsky, Y.; Bicakci; Birabwa-Oketcho, H.; Bjella, T. D.; Bossini, L.; Cabrera, J.; Cheung, E. Y.W.; Del Zompo, M.; Dodd, S.; Donix, M.; Etain, B.; Fagiolini, A.; Fountoulakis, K. N.; Frye, Mark A; Gonzalez-Pinto, A.; Gottlieb, J. F.; Grof, P.; Harima, H.; Henry, C.; Isometsä, E. T.; Janno, S.; Kapczinski, F.; Kardell, M.; Khaldi, S.; Kliwicki, S.; König, B.; Kot, T. L.; Krogh, R.; Kunz, M.; Lafer, B.; Landén, M.; Larsen, E. R.; Lewitzka, U.; Licht, R. W.; Lopez-Jaramillo, C.; MacQueen, G.; Manchia, M.; Marsh, W.; Martinez-Cengotitabengoa, M.; Melle, I.; Meza-Urzúa, F.; Yee Ming, M.; Monteith, S.; Morken, G.; Mosca, E.; Munoz, R.; Mythri, S. V.; Nacef, F.; Nadella, R. K.; Nery, F. G.; Nielsen, R. E.; O'Donovan, C.; Omrani, A.; Osher, Y.; Østermark Sørensen, H.; Ouali, U.; Pica Ruiz, Y.; Pilhatsch, M.; Pinna, M.; da Ponte, F. D.R.; Quiroz, D.; Ramesar, R.; Rasgon, N.; Reddy, M. S.; Reif, A.; Ritter, P.; Rybakowski, J. K.; Sagduyu, K.; Scippa, M.; Severus, E.; Simhandl, C.; Stein, D. J.; Strejilevich, S.; Subramaniam, M.; Sulaiman, A. H.; Suominen, K.; Tagata, H.; Tatebayashi, Y.; Tondo, L.; Torrent, C.; Vaaler, A. E.; Veeh, J.; Vieta, E.; Viswanath, B.; Yoldi-Negrete, M.; Zetin, M.; Zgueb, Y.; Whybrow, P. C.

In: Acta Psychiatrica Scandinavica, Vol. 136, No. 6, 01.12.2017, p. 571-582.

Research output: Contribution to journalArticle

Bauer, M, Glenn, T, Alda, M, Aleksandrovich, MA, Andreassen, OA, Angelopoulos, E, Ardau, R, Ayhan, Y, Baethge, C, Bharathram, SR, Bauer, R, Baune, BT, Becerra-Palars, C, Bellivier, F, Belmaker, RH, Berk, M, Bersudsky, Y, Bicakci, Birabwa-Oketcho, H, Bjella, TD, Bossini, L, Cabrera, J, Cheung, EYW, Del Zompo, M, Dodd, S, Donix, M, Etain, B, Fagiolini, A, Fountoulakis, KN, Frye, MA, Gonzalez-Pinto, A, Gottlieb, JF, Grof, P, Harima, H, Henry, C, Isometsä, ET, Janno, S, Kapczinski, F, Kardell, M, Khaldi, S, Kliwicki, S, König, B, Kot, TL, Krogh, R, Kunz, M, Lafer, B, Landén, M, Larsen, ER, Lewitzka, U, Licht, RW, Lopez-Jaramillo, C, MacQueen, G, Manchia, M, Marsh, W, Martinez-Cengotitabengoa, M, Melle, I, Meza-Urzúa, F, Yee Ming, M, Monteith, S, Morken, G, Mosca, E, Munoz, R, Mythri, SV, Nacef, F, Nadella, RK, Nery, FG, Nielsen, RE, O'Donovan, C, Omrani, A, Osher, Y, Østermark Sørensen, H, Ouali, U, Pica Ruiz, Y, Pilhatsch, M, Pinna, M, da Ponte, FDR, Quiroz, D, Ramesar, R, Rasgon, N, Reddy, MS, Reif, A, Ritter, P, Rybakowski, JK, Sagduyu, K, Scippa, M, Severus, E, Simhandl, C, Stein, DJ, Strejilevich, S, Subramaniam, M, Sulaiman, AH, Suominen, K, Tagata, H, Tatebayashi, Y, Tondo, L, Torrent, C, Vaaler, AE, Veeh, J, Vieta, E, Viswanath, B, Yoldi-Negrete, M, Zetin, M, Zgueb, Y & Whybrow, PC 2017, 'Solar insolation in springtime influences age of onset of bipolar I disorder', Acta Psychiatrica Scandinavica, vol. 136, no. 6, pp. 571-582. https://doi.org/10.1111/acps.12772
Bauer M, Glenn T, Alda M, Aleksandrovich MA, Andreassen OA, Angelopoulos E et al. Solar insolation in springtime influences age of onset of bipolar I disorder. Acta Psychiatrica Scandinavica. 2017 Dec 1;136(6):571-582. https://doi.org/10.1111/acps.12772
Bauer, M. ; Glenn, T. ; Alda, M. ; Aleksandrovich, M. A. ; Andreassen, O. A. ; Angelopoulos, E. ; Ardau, R. ; Ayhan, Y. ; Baethge, C. ; Bharathram, S. R. ; Bauer, R. ; Baune, B. T. ; Becerra-Palars, C. ; Bellivier, F. ; Belmaker, R. H. ; Berk, M. ; Bersudsky, Y. ; Bicakci ; Birabwa-Oketcho, H. ; Bjella, T. D. ; Bossini, L. ; Cabrera, J. ; Cheung, E. Y.W. ; Del Zompo, M. ; Dodd, S. ; Donix, M. ; Etain, B. ; Fagiolini, A. ; Fountoulakis, K. N. ; Frye, Mark A ; Gonzalez-Pinto, A. ; Gottlieb, J. F. ; Grof, P. ; Harima, H. ; Henry, C. ; Isometsä, E. T. ; Janno, S. ; Kapczinski, F. ; Kardell, M. ; Khaldi, S. ; Kliwicki, S. ; König, B. ; Kot, T. L. ; Krogh, R. ; Kunz, M. ; Lafer, B. ; Landén, M. ; Larsen, E. R. ; Lewitzka, U. ; Licht, R. W. ; Lopez-Jaramillo, C. ; MacQueen, G. ; Manchia, M. ; Marsh, W. ; Martinez-Cengotitabengoa, M. ; Melle, I. ; Meza-Urzúa, F. ; Yee Ming, M. ; Monteith, S. ; Morken, G. ; Mosca, E. ; Munoz, R. ; Mythri, S. V. ; Nacef, F. ; Nadella, R. K. ; Nery, F. G. ; Nielsen, R. E. ; O'Donovan, C. ; Omrani, A. ; Osher, Y. ; Østermark Sørensen, H. ; Ouali, U. ; Pica Ruiz, Y. ; Pilhatsch, M. ; Pinna, M. ; da Ponte, F. D.R. ; Quiroz, D. ; Ramesar, R. ; Rasgon, N. ; Reddy, M. S. ; Reif, A. ; Ritter, P. ; Rybakowski, J. K. ; Sagduyu, K. ; Scippa, M. ; Severus, E. ; Simhandl, C. ; Stein, D. J. ; Strejilevich, S. ; Subramaniam, M. ; Sulaiman, A. H. ; Suominen, K. ; Tagata, H. ; Tatebayashi, Y. ; Tondo, L. ; Torrent, C. ; Vaaler, A. E. ; Veeh, J. ; Vieta, E. ; Viswanath, B. ; Yoldi-Negrete, M. ; Zetin, M. ; Zgueb, Y. ; Whybrow, P. C. / Solar insolation in springtime influences age of onset of bipolar I disorder. In: Acta Psychiatrica Scandinavica. 2017 ; Vol. 136, No. 6. pp. 571-582.
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abstract = "Objective: To confirm prior findings that the larger the maximum monthly increase in solar insolation in springtime, the younger the age of onset of bipolar disorder. Method: Data were collected from 5536 patients at 50 sites in 32 countries on six continents. Onset occurred at 456 locations in 57 countries. Variables included solar insolation, birth-cohort, family history, polarity of first episode and country physician density. Results: There was a significant, inverse association between the maximum monthly increase in solar insolation at the onset location, and the age of onset. This effect was reduced in those without a family history of mood disorders and with a first episode of mania rather than depression. The maximum monthly increase occurred in springtime. The youngest birth-cohort had the youngest age of onset. All prior relationships were confirmed using both the entire sample, and only the youngest birth-cohort (all estimated coefficients P < 0.001). Conclusion: A large increase in springtime solar insolation may impact the onset of bipolar disorder, especially with a family history of mood disorders. Recent societal changes that affect light exposure (LED lighting, mobile devices backlit with LEDs) may influence adaptability to a springtime circadian challenge.",
keywords = "bipolar disorder, circadian rhythm, epidemiology, solar insolation",
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TY - JOUR

T1 - Solar insolation in springtime influences age of onset of bipolar I disorder

AU - Bauer, M.

AU - Glenn, T.

AU - Alda, M.

AU - Aleksandrovich, M. A.

AU - Andreassen, O. A.

AU - Angelopoulos, E.

AU - Ardau, R.

AU - Ayhan, Y.

AU - Baethge, C.

AU - Bharathram, S. R.

AU - Bauer, R.

AU - Baune, B. T.

AU - Becerra-Palars, C.

AU - Bellivier, F.

AU - Belmaker, R. H.

AU - Berk, M.

AU - Bersudsky, Y.

AU - Bicakci,

AU - Birabwa-Oketcho, H.

AU - Bjella, T. D.

AU - Bossini, L.

AU - Cabrera, J.

AU - Cheung, E. Y.W.

AU - Del Zompo, M.

AU - Dodd, S.

AU - Donix, M.

AU - Etain, B.

AU - Fagiolini, A.

AU - Fountoulakis, K. N.

AU - Frye, Mark A

AU - Gonzalez-Pinto, A.

AU - Gottlieb, J. F.

AU - Grof, P.

AU - Harima, H.

AU - Henry, C.

AU - Isometsä, E. T.

AU - Janno, S.

AU - Kapczinski, F.

AU - Kardell, M.

AU - Khaldi, S.

AU - Kliwicki, S.

AU - König, B.

AU - Kot, T. L.

AU - Krogh, R.

AU - Kunz, M.

AU - Lafer, B.

AU - Landén, M.

AU - Larsen, E. R.

AU - Lewitzka, U.

AU - Licht, R. W.

AU - Lopez-Jaramillo, C.

AU - MacQueen, G.

AU - Manchia, M.

AU - Marsh, W.

AU - Martinez-Cengotitabengoa, M.

AU - Melle, I.

AU - Meza-Urzúa, F.

AU - Yee Ming, M.

AU - Monteith, S.

AU - Morken, G.

AU - Mosca, E.

AU - Munoz, R.

AU - Mythri, S. V.

AU - Nacef, F.

AU - Nadella, R. K.

AU - Nery, F. G.

AU - Nielsen, R. E.

AU - O'Donovan, C.

AU - Omrani, A.

AU - Osher, Y.

AU - Østermark Sørensen, H.

AU - Ouali, U.

AU - Pica Ruiz, Y.

AU - Pilhatsch, M.

AU - Pinna, M.

AU - da Ponte, F. D.R.

AU - Quiroz, D.

AU - Ramesar, R.

AU - Rasgon, N.

AU - Reddy, M. S.

AU - Reif, A.

AU - Ritter, P.

AU - Rybakowski, J. K.

AU - Sagduyu, K.

AU - Scippa, M.

AU - Severus, E.

AU - Simhandl, C.

AU - Stein, D. J.

AU - Strejilevich, S.

AU - Subramaniam, M.

AU - Sulaiman, A. H.

AU - Suominen, K.

AU - Tagata, H.

AU - Tatebayashi, Y.

AU - Tondo, L.

AU - Torrent, C.

AU - Vaaler, A. E.

AU - Veeh, J.

AU - Vieta, E.

AU - Viswanath, B.

AU - Yoldi-Negrete, M.

AU - Zetin, M.

AU - Zgueb, Y.

AU - Whybrow, P. C.

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Objective: To confirm prior findings that the larger the maximum monthly increase in solar insolation in springtime, the younger the age of onset of bipolar disorder. Method: Data were collected from 5536 patients at 50 sites in 32 countries on six continents. Onset occurred at 456 locations in 57 countries. Variables included solar insolation, birth-cohort, family history, polarity of first episode and country physician density. Results: There was a significant, inverse association between the maximum monthly increase in solar insolation at the onset location, and the age of onset. This effect was reduced in those without a family history of mood disorders and with a first episode of mania rather than depression. The maximum monthly increase occurred in springtime. The youngest birth-cohort had the youngest age of onset. All prior relationships were confirmed using both the entire sample, and only the youngest birth-cohort (all estimated coefficients P < 0.001). Conclusion: A large increase in springtime solar insolation may impact the onset of bipolar disorder, especially with a family history of mood disorders. Recent societal changes that affect light exposure (LED lighting, mobile devices backlit with LEDs) may influence adaptability to a springtime circadian challenge.

AB - Objective: To confirm prior findings that the larger the maximum monthly increase in solar insolation in springtime, the younger the age of onset of bipolar disorder. Method: Data were collected from 5536 patients at 50 sites in 32 countries on six continents. Onset occurred at 456 locations in 57 countries. Variables included solar insolation, birth-cohort, family history, polarity of first episode and country physician density. Results: There was a significant, inverse association between the maximum monthly increase in solar insolation at the onset location, and the age of onset. This effect was reduced in those without a family history of mood disorders and with a first episode of mania rather than depression. The maximum monthly increase occurred in springtime. The youngest birth-cohort had the youngest age of onset. All prior relationships were confirmed using both the entire sample, and only the youngest birth-cohort (all estimated coefficients P < 0.001). Conclusion: A large increase in springtime solar insolation may impact the onset of bipolar disorder, especially with a family history of mood disorders. Recent societal changes that affect light exposure (LED lighting, mobile devices backlit with LEDs) may influence adaptability to a springtime circadian challenge.

KW - bipolar disorder

KW - circadian rhythm

KW - epidemiology

KW - solar insolation

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U2 - 10.1111/acps.12772

DO - 10.1111/acps.12772

M3 - Article

C2 - 28722128

AN - SCOPUS:85025072706

VL - 136

SP - 571

EP - 582

JO - Acta Psychiatrica Scandinavica

JF - Acta Psychiatrica Scandinavica

SN - 0001-690X

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ER -