Soft-tissue perineurioma: Evidence for an abnormality of chromosome 22, criteria for diagnosis, and review of the literature

Caterina Giannini, Bernd W. Scheithauer, Robert Brian Jenkins, Robert A. Erlandson, Arie Perry, Tom J. Borell, Rana S. Hoda, James M. Woodruff

Research output: Contribution to journalArticle

168 Citations (Scopus)

Abstract

Reported herein are two examples of soft-tissue perineurioma (STP), one arising in the maxillary sinus and the other in subcutaneous tissue of the thigh. Electron microscopy and immunohistochemistry were performed in both cases. Based on our findings and a critical review of the literature. STPs are generally small, well-circumscribed but not encapsulated tumors. Histologically, most STPs resemble fibroblastic tumors, being composed of elongated, wavy cells. The immunohistochemical reactivity for epithelial membrane antigen, the lack of reactivity for S-100 protein, and the presence of ultrastructural features of perineurial cells are typical of this tumor. To explore the possibility that STP, like the intraneural variety of perineurioma, exhibits an abnormality of chromosome 22, we performed fluorescence in situ hybridization with a probe specific for the M-bcr locus, which maps to the chromosome band 22q11. In both our tumors, a high percentage of nuclei having only one M-bcr signal (44 and 96%) was observed. Our findings indicated deletion of part or all of chromosome 22 and support the view that both soft-tissue and intraneural perineurioma are part of a spectrum of perineurial neoplasia.

Original languageEnglish (US)
Pages (from-to)164-173
Number of pages10
JournalAmerican Journal of Surgical Pathology
Volume21
Issue number2
DOIs
StatePublished - 1997

Fingerprint

Nerve Sheath Neoplasms
Chromosomes, Human, Pair 22
Neoplasms
Minor Lymphocyte Stimulatory Loci
Mucin-1
S100 Proteins
Maxillary Sinus
Subcutaneous Tissue
Thigh
Fluorescence In Situ Hybridization
Electron Microscopy
Chromosomes
Immunohistochemistry

Keywords

  • Cytogenetics
  • Diagnosis
  • Immunohistochemistry
  • Perineurioma
  • Ultrastructure

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

Cite this

Soft-tissue perineurioma : Evidence for an abnormality of chromosome 22, criteria for diagnosis, and review of the literature. / Giannini, Caterina; Scheithauer, Bernd W.; Jenkins, Robert Brian; Erlandson, Robert A.; Perry, Arie; Borell, Tom J.; Hoda, Rana S.; Woodruff, James M.

In: American Journal of Surgical Pathology, Vol. 21, No. 2, 1997, p. 164-173.

Research output: Contribution to journalArticle

Giannini, Caterina ; Scheithauer, Bernd W. ; Jenkins, Robert Brian ; Erlandson, Robert A. ; Perry, Arie ; Borell, Tom J. ; Hoda, Rana S. ; Woodruff, James M. / Soft-tissue perineurioma : Evidence for an abnormality of chromosome 22, criteria for diagnosis, and review of the literature. In: American Journal of Surgical Pathology. 1997 ; Vol. 21, No. 2. pp. 164-173.
@article{f5ffe392f27e42aeb2ccc19dc33de4ac,
title = "Soft-tissue perineurioma: Evidence for an abnormality of chromosome 22, criteria for diagnosis, and review of the literature",
abstract = "Reported herein are two examples of soft-tissue perineurioma (STP), one arising in the maxillary sinus and the other in subcutaneous tissue of the thigh. Electron microscopy and immunohistochemistry were performed in both cases. Based on our findings and a critical review of the literature. STPs are generally small, well-circumscribed but not encapsulated tumors. Histologically, most STPs resemble fibroblastic tumors, being composed of elongated, wavy cells. The immunohistochemical reactivity for epithelial membrane antigen, the lack of reactivity for S-100 protein, and the presence of ultrastructural features of perineurial cells are typical of this tumor. To explore the possibility that STP, like the intraneural variety of perineurioma, exhibits an abnormality of chromosome 22, we performed fluorescence in situ hybridization with a probe specific for the M-bcr locus, which maps to the chromosome band 22q11. In both our tumors, a high percentage of nuclei having only one M-bcr signal (44 and 96{\%}) was observed. Our findings indicated deletion of part or all of chromosome 22 and support the view that both soft-tissue and intraneural perineurioma are part of a spectrum of perineurial neoplasia.",
keywords = "Cytogenetics, Diagnosis, Immunohistochemistry, Perineurioma, Ultrastructure",
author = "Caterina Giannini and Scheithauer, {Bernd W.} and Jenkins, {Robert Brian} and Erlandson, {Robert A.} and Arie Perry and Borell, {Tom J.} and Hoda, {Rana S.} and Woodruff, {James M.}",
year = "1997",
doi = "10.1097/00000478-199702000-00005",
language = "English (US)",
volume = "21",
pages = "164--173",
journal = "American Journal of Surgical Pathology",
issn = "0147-5185",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Soft-tissue perineurioma

T2 - Evidence for an abnormality of chromosome 22, criteria for diagnosis, and review of the literature

AU - Giannini, Caterina

AU - Scheithauer, Bernd W.

AU - Jenkins, Robert Brian

AU - Erlandson, Robert A.

AU - Perry, Arie

AU - Borell, Tom J.

AU - Hoda, Rana S.

AU - Woodruff, James M.

PY - 1997

Y1 - 1997

N2 - Reported herein are two examples of soft-tissue perineurioma (STP), one arising in the maxillary sinus and the other in subcutaneous tissue of the thigh. Electron microscopy and immunohistochemistry were performed in both cases. Based on our findings and a critical review of the literature. STPs are generally small, well-circumscribed but not encapsulated tumors. Histologically, most STPs resemble fibroblastic tumors, being composed of elongated, wavy cells. The immunohistochemical reactivity for epithelial membrane antigen, the lack of reactivity for S-100 protein, and the presence of ultrastructural features of perineurial cells are typical of this tumor. To explore the possibility that STP, like the intraneural variety of perineurioma, exhibits an abnormality of chromosome 22, we performed fluorescence in situ hybridization with a probe specific for the M-bcr locus, which maps to the chromosome band 22q11. In both our tumors, a high percentage of nuclei having only one M-bcr signal (44 and 96%) was observed. Our findings indicated deletion of part or all of chromosome 22 and support the view that both soft-tissue and intraneural perineurioma are part of a spectrum of perineurial neoplasia.

AB - Reported herein are two examples of soft-tissue perineurioma (STP), one arising in the maxillary sinus and the other in subcutaneous tissue of the thigh. Electron microscopy and immunohistochemistry were performed in both cases. Based on our findings and a critical review of the literature. STPs are generally small, well-circumscribed but not encapsulated tumors. Histologically, most STPs resemble fibroblastic tumors, being composed of elongated, wavy cells. The immunohistochemical reactivity for epithelial membrane antigen, the lack of reactivity for S-100 protein, and the presence of ultrastructural features of perineurial cells are typical of this tumor. To explore the possibility that STP, like the intraneural variety of perineurioma, exhibits an abnormality of chromosome 22, we performed fluorescence in situ hybridization with a probe specific for the M-bcr locus, which maps to the chromosome band 22q11. In both our tumors, a high percentage of nuclei having only one M-bcr signal (44 and 96%) was observed. Our findings indicated deletion of part or all of chromosome 22 and support the view that both soft-tissue and intraneural perineurioma are part of a spectrum of perineurial neoplasia.

KW - Cytogenetics

KW - Diagnosis

KW - Immunohistochemistry

KW - Perineurioma

KW - Ultrastructure

UR - http://www.scopus.com/inward/record.url?scp=0031051644&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031051644&partnerID=8YFLogxK

U2 - 10.1097/00000478-199702000-00005

DO - 10.1097/00000478-199702000-00005

M3 - Article

C2 - 9042282

AN - SCOPUS:0031051644

VL - 21

SP - 164

EP - 173

JO - American Journal of Surgical Pathology

JF - American Journal of Surgical Pathology

SN - 0147-5185

IS - 2

ER -