TY - JOUR
T1 - Soft-tissue amyloidoma of the extremities
T2 - A case report and review of literature
AU - Maheshwari, Aditya V.
AU - Muro-Cacho, Carlos A.
AU - Kransdorf, Mark J.
AU - Temple, H. Thomas
N1 - Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.
PY - 2009/3
Y1 - 2009/3
N2 - Amyloidosis is a heterogeneous group of disorders characterized by extracellular deposition of unique protein fibrils. Amyloidosis may be hereditary or acquired, and the deposits may be focal, localized, or systemic in distribution. The least common presentation of an amyloid deposition is as a discrete mass called amyloidoma or amyloid tumor. Although described at various body sites, soft-tissue amyloidoma in an extremity is exceedingly rare. We report such a case of a large amyloidoma in the thigh, which simulated a soft-tissue sarcoma. In spite of attaining a very large size over a course of more than 20 years, the clinical course and the histology of this lesion were benign. Awareness of this entity will allow this rare diagnosis to be considered, prevent confusion with malignant disease, and allow appropriate management and patient reassurance. A review of literature on soft-tissue amyloidomas of extremities is also being presented.
AB - Amyloidosis is a heterogeneous group of disorders characterized by extracellular deposition of unique protein fibrils. Amyloidosis may be hereditary or acquired, and the deposits may be focal, localized, or systemic in distribution. The least common presentation of an amyloid deposition is as a discrete mass called amyloidoma or amyloid tumor. Although described at various body sites, soft-tissue amyloidoma in an extremity is exceedingly rare. We report such a case of a large amyloidoma in the thigh, which simulated a soft-tissue sarcoma. In spite of attaining a very large size over a course of more than 20 years, the clinical course and the histology of this lesion were benign. Awareness of this entity will allow this rare diagnosis to be considered, prevent confusion with malignant disease, and allow appropriate management and patient reassurance. A review of literature on soft-tissue amyloidomas of extremities is also being presented.
KW - Amyloidoma
KW - Amyloidosis
KW - Extremity amyloidoma
KW - Soft-tissue amyloidoma
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U2 - 10.1007/s00256-008-0621-6
DO - 10.1007/s00256-008-0621-6
M3 - Article
C2 - 19050870
AN - SCOPUS:58849144221
SN - 0364-2348
VL - 38
SP - 287
EP - 292
JO - Skeletal Radiology
JF - Skeletal Radiology
IS - 3
ER -