Lithium ion efflux by murine neuroblastoma (clone N1E-115) and rat glioma (clone C6) cells was studied to determine the presence of a phloretin-sensitive sodiumlithium countertransport pathway which has been found in human erythrocytes. Although this pathway could be identified in these cultured cells, unlike that in red blood cells, it was a very minor (less than 20%) component of the overall efflux of lithium ions from these cells of nervous tissue origin.
- Cultured cells
- Lithium ions
- Sodium-dependent lithium efflux
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