Snapshots of ispinesib-induced conformational changes in the mitotic kinesin eg5

Hung Yi Kristal Kaan, Jennifer Major, Katarzyna Tkocz, Frank Kozielski, Steven S. Rosenfeld

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Background: Ispinesib is a small molecule inhibitor of Eg5 and induces neck linker docking. Results: Ispinesib binding to Eg5 induces subsequent movement of switch II. Conclusion: Conformational changes in L5 can alter the orientation of the neck linker regardless of the state of the catalytic site. Significance: L5 is a key regulator of both the catalytic site and switch II.

Original languageEnglish (US)
Pages (from-to)18588-18598
Number of pages11
JournalJournal of Biological Chemistry
Volume288
Issue number25
DOIs
StatePublished - Jun 21 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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