Abstract
Background: Ispinesib is a small molecule inhibitor of Eg5 and induces neck linker docking. Results: Ispinesib binding to Eg5 induces subsequent movement of switch II. Conclusion: Conformational changes in L5 can alter the orientation of the neck linker regardless of the state of the catalytic site. Significance: L5 is a key regulator of both the catalytic site and switch II.
Original language | English (US) |
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Pages (from-to) | 18588-18598 |
Number of pages | 11 |
Journal | Journal of Biological Chemistry |
Volume | 288 |
Issue number | 25 |
DOIs | |
State | Published - Jun 21 2013 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology