TY - JOUR
T1 - Snapshots of ispinesib-induced conformational changes in the mitotic kinesin eg5
AU - Kaan, Hung Yi Kristal
AU - Major, Jennifer
AU - Tkocz, Katarzyna
AU - Kozielski, Frank
AU - Rosenfeld, Steven S.
PY - 2013/6/21
Y1 - 2013/6/21
N2 - Background: Ispinesib is a small molecule inhibitor of Eg5 and induces neck linker docking. Results: Ispinesib binding to Eg5 induces subsequent movement of switch II. Conclusion: Conformational changes in L5 can alter the orientation of the neck linker regardless of the state of the catalytic site. Significance: L5 is a key regulator of both the catalytic site and switch II.
AB - Background: Ispinesib is a small molecule inhibitor of Eg5 and induces neck linker docking. Results: Ispinesib binding to Eg5 induces subsequent movement of switch II. Conclusion: Conformational changes in L5 can alter the orientation of the neck linker regardless of the state of the catalytic site. Significance: L5 is a key regulator of both the catalytic site and switch II.
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U2 - 10.1074/jbc.M113.462648
DO - 10.1074/jbc.M113.462648
M3 - Article
C2 - 23658017
AN - SCOPUS:84880052495
SN - 0021-9258
VL - 288
SP - 18588
EP - 18598
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 25
ER -