Snake neurotoxins: Effect of disulfide reduction on interaction with electroplax

Eva Bartels, Terrone L. Rosenberry

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Reduction of disulfide bonds of cobra neurotoxin by dithiothreitol results in decreased activity on the electroplax preparation. Activity is restored completely after reoxidation by 3,3′-dithiobis[6-nitrobenzoic acid]. Reduction of the disulfide bonds in the vicinity of the receptor does not decrease the effect of cobrotoxin.

Original languageEnglish (US)
Pages (from-to)1236-1237
Number of pages2
JournalScience
Volume174
Issue number4015
DOIs
StatePublished - Jan 1 1971

ASJC Scopus subject areas

  • General

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