Smooth muscle progenitor cells in vascular disease

Chunsheng Liu, Karl A Nath, Zvonimir S Katusic, Noel M. Caplice

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Vascular smooth muscle cells have long been described as phenotypically diverse, with some populations possessing the potential for monoclonal expansion within the adult vessel wall. Recent experimental and human data suggest a potential role in atherosclerotic plaque, transplant arteriopathy, and angiogenesis biology for putative smooth muscle progenitor cells in the circulation, adult tissues, and the perivascular adventitia. The location, mobilization, and function of such progenitors is still poorly understood, but may include reparative or alternatively proliferative consequences for plaque development and progression. These observations provide a platform for re-evaluation of smooth muscle cell heterogeneity and progenitor biology in atherosclerosis, with implications for diagnosis and therapy of vascular disease.

Original languageEnglish (US)
Pages (from-to)288-293
Number of pages6
JournalTrends in Cardiovascular Medicine
Volume14
Issue number7
DOIs
StatePublished - Oct 2004
Externally publishedYes

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Vascular Diseases
Smooth Muscle Myocytes
Stem Cells
Adventitia
Atherosclerotic Plaques
Vascular Smooth Muscle
Atherosclerosis
Transplants
Population
Therapeutics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Smooth muscle progenitor cells in vascular disease. / Liu, Chunsheng; Nath, Karl A; Katusic, Zvonimir S; Caplice, Noel M.

In: Trends in Cardiovascular Medicine, Vol. 14, No. 7, 10.2004, p. 288-293.

Research output: Contribution to journalArticle

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