Smoking-Related—Interstitial Lung Disease

This article highlights the smoking-related interstitial lung diseases including respiratory bronchiolitis-associated interstitial lung disease (RB-ILD), desquamative interstitial pneumonia (DIP), pulmonary Langerhans cell histiocytosis (PLCH), combined pulmonary fibrosis and emphysema (CPFE) and smoking-related interstitial fibrosis (SRIF). All share cigarette smoking as a likely cause of presenting disease, of which characteristic clinical findings, radiologic features, and histopathology will be reviewed. For a majority of the smoking-related interstitial lung diseases, smoking cessation is a vital first step to reversing disease course or slowing progression, along with directed anti-inflammatory or immunosuppressant therapy.