Smoking-related idiopathic interstitial pneumonia

Kevin R. Flaherty, Charlene Fell, Marie Christine Aubry, Kevin Brown, Thomas Colby, Ulrich Costabel, Teri J. Franks, Barry H. Gross, David M. Hansell, Ella Kazerooni, Dong Soon Kim, Talmadge E. King, Masanori Kitachi, David Lynch, Jeff Myers, Sonoko Nagai, Andrew G. Nicholson, Venerino Poletti, Ganesh Raghu, Moises SelmanGalen Toews, William Travis, Athol U. Wells, Robert Vassallo, Fernando J. Martinez

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Cigarette smoking is a key factor in the development of numerous pulmonary diseases. An international group of clinicians, radiologists and pathologists evaluated patients with previously identified idiopathic interstitial pneumonia (IIP) to determine unique features of cigarette smoking. Phase 1 (derivation group) identified smoking-related features in patients with a history of smoking (n541). Phase 2 (validation group) determined if these features correctly predicted the smoking status of IIP patients (n5100) to participants blinded to smoking history. Finally, the investigators sought to determine if a new smoking-related interstitial lung disease phenotype could be defined. Phase 1 suggested that preserved forced vital capacity with disproportionately reduced diffusing capacity of the lung for carbon monoxide, and various radiographic and histopathological findings were smoking-related features. In phase 2, the kappa coefficient among clinicians was 0.16 (95% CI 0.11-0.21), among the pathologists 0.36 (95% CI 0.32-0.40) and among the radiologists 0.43 (95% CI 0.35-0.52) for smoking-related features. Eight of the 100 cases were felt to represent a potential smoking-related interstitial lung disease. Smoking-related features of interstitial lung disease were identified in a minority of smokers and were not specific for smoking. This study is limited by its retrospective design, the potential for recall bias in smoking history and lack of information on second-hand smoke exposure. Further research is needed to understand the relationship between smoking and interstitial lung disease.

Original languageEnglish (US)
Pages (from-to)594-602
Number of pages9
JournalEuropean Respiratory Journal
Volume44
Issue number3
DOIs
StatePublished - Sep 1 2014

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Idiopathic Interstitial Pneumonias
Smoking
Interstitial Lung Diseases
History
Lung Volume Measurements
Tobacco Smoke Pollution
Vital Capacity
Carbon Monoxide

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Flaherty, K. R., Fell, C., Aubry, M. C., Brown, K., Colby, T., Costabel, U., ... Martinez, F. J. (2014). Smoking-related idiopathic interstitial pneumonia. European Respiratory Journal, 44(3), 594-602. https://doi.org/10.1183/09031936.00166813

Smoking-related idiopathic interstitial pneumonia. / Flaherty, Kevin R.; Fell, Charlene; Aubry, Marie Christine; Brown, Kevin; Colby, Thomas; Costabel, Ulrich; Franks, Teri J.; Gross, Barry H.; Hansell, David M.; Kazerooni, Ella; Kim, Dong Soon; King, Talmadge E.; Kitachi, Masanori; Lynch, David; Myers, Jeff; Nagai, Sonoko; Nicholson, Andrew G.; Poletti, Venerino; Raghu, Ganesh; Selman, Moises; Toews, Galen; Travis, William; Wells, Athol U.; Vassallo, Robert; Martinez, Fernando J.

In: European Respiratory Journal, Vol. 44, No. 3, 01.09.2014, p. 594-602.

Research output: Contribution to journalArticle

Flaherty, KR, Fell, C, Aubry, MC, Brown, K, Colby, T, Costabel, U, Franks, TJ, Gross, BH, Hansell, DM, Kazerooni, E, Kim, DS, King, TE, Kitachi, M, Lynch, D, Myers, J, Nagai, S, Nicholson, AG, Poletti, V, Raghu, G, Selman, M, Toews, G, Travis, W, Wells, AU, Vassallo, R & Martinez, FJ 2014, 'Smoking-related idiopathic interstitial pneumonia', European Respiratory Journal, vol. 44, no. 3, pp. 594-602. https://doi.org/10.1183/09031936.00166813
Flaherty KR, Fell C, Aubry MC, Brown K, Colby T, Costabel U et al. Smoking-related idiopathic interstitial pneumonia. European Respiratory Journal. 2014 Sep 1;44(3):594-602. https://doi.org/10.1183/09031936.00166813
Flaherty, Kevin R. ; Fell, Charlene ; Aubry, Marie Christine ; Brown, Kevin ; Colby, Thomas ; Costabel, Ulrich ; Franks, Teri J. ; Gross, Barry H. ; Hansell, David M. ; Kazerooni, Ella ; Kim, Dong Soon ; King, Talmadge E. ; Kitachi, Masanori ; Lynch, David ; Myers, Jeff ; Nagai, Sonoko ; Nicholson, Andrew G. ; Poletti, Venerino ; Raghu, Ganesh ; Selman, Moises ; Toews, Galen ; Travis, William ; Wells, Athol U. ; Vassallo, Robert ; Martinez, Fernando J. / Smoking-related idiopathic interstitial pneumonia. In: European Respiratory Journal. 2014 ; Vol. 44, No. 3. pp. 594-602.
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AU - Kitachi, Masanori

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AU - Myers, Jeff

AU - Nagai, Sonoko

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AU - Poletti, Venerino

AU - Raghu, Ganesh

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