Smoking is associated with chronic sympathetic activation in hypertension

Dagmara Hering, Wieslawa Kucharska, Tomas Kara, Virend Somers, Krzysztof Narkiewicz

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Objective. Previous studies have shown that smoking contributes importantly to short-term modulation of sympathetic nerve traffic. However, effect of smoking status on resting muscle sympathetic nerve activity (MSNA) in hypertension is unknown. Therefore, we tested the hypothesis that smoking is associated with chronic sympathetic activation in patients with essential hypertension. Methods. We measured MSNA, heart rate (HR) and blood pressure during undisturbed supine rest and in 30 hypertensive smokers (22 males, age 38±4 years, body mass index, BMI 27±1 kg/m 2, mean±SEM). These measurements were compared with those obtained 38 non-smoking hypertensive patients matched for gender, age and BMI. All hypertensives underwent 24-h ambulatory blood pressure monitoring. Patients were newly diagnosed, never treated for hypertension and were free of any other known diseases. Results. In comparison with non-smokers, smokers had smaller officedaytime systolic blood pressure difference (6±2 vs 15±3 mmHg, respectively; p<0.01). Despite similar resting values, HR in smokers was greater than in non-smokers during both daytime (86±3 vs 77±2 beats/min, respectively; p< 0.001) and night-time (73±3 vs 66±2 beats/min, respectively; p<0.01). MSNA was elevated in smokers (36±3 bursts/min) compared with non-smokers (28±3 bursts/min; p<0.01). Similar results were obtained when MSNA was expressed as bursts/100 heart beats. Multiple linear regression analysis revealed that only age and smoking status were linked independently to MSNA (R 2=0.42, p< 0.001). Conclusions. In patients with essential hypertension, smoking is independently associated with chronic increase in MSNA. These findings may have implications for our understanding of the mechanisms linking smoking to cardiovascular events.

Original languageEnglish (US)
Pages (from-to)152-155
Number of pages4
JournalBlood Pressure
Volume19
Issue number3
DOIs
StatePublished - 2010

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Smoking
Hypertension
Muscles
Blood Pressure
Heart Rate
Ambulatory Blood Pressure Monitoring
Linear Models
Body Mass Index
Regression Analysis
Essential Hypertension

Keywords

  • Cardiovascular disease
  • Heart rate
  • Hypertension
  • Smoking
  • Sympathetic nervous system

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Smoking is associated with chronic sympathetic activation in hypertension. / Hering, Dagmara; Kucharska, Wieslawa; Kara, Tomas; Somers, Virend; Narkiewicz, Krzysztof.

In: Blood Pressure, Vol. 19, No. 3, 2010, p. 152-155.

Research output: Contribution to journalArticle

Hering, Dagmara ; Kucharska, Wieslawa ; Kara, Tomas ; Somers, Virend ; Narkiewicz, Krzysztof. / Smoking is associated with chronic sympathetic activation in hypertension. In: Blood Pressure. 2010 ; Vol. 19, No. 3. pp. 152-155.
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abstract = "Objective. Previous studies have shown that smoking contributes importantly to short-term modulation of sympathetic nerve traffic. However, effect of smoking status on resting muscle sympathetic nerve activity (MSNA) in hypertension is unknown. Therefore, we tested the hypothesis that smoking is associated with chronic sympathetic activation in patients with essential hypertension. Methods. We measured MSNA, heart rate (HR) and blood pressure during undisturbed supine rest and in 30 hypertensive smokers (22 males, age 38±4 years, body mass index, BMI 27±1 kg/m 2, mean±SEM). These measurements were compared with those obtained 38 non-smoking hypertensive patients matched for gender, age and BMI. All hypertensives underwent 24-h ambulatory blood pressure monitoring. Patients were newly diagnosed, never treated for hypertension and were free of any other known diseases. Results. In comparison with non-smokers, smokers had smaller officedaytime systolic blood pressure difference (6±2 vs 15±3 mmHg, respectively; p<0.01). Despite similar resting values, HR in smokers was greater than in non-smokers during both daytime (86±3 vs 77±2 beats/min, respectively; p< 0.001) and night-time (73±3 vs 66±2 beats/min, respectively; p<0.01). MSNA was elevated in smokers (36±3 bursts/min) compared with non-smokers (28±3 bursts/min; p<0.01). Similar results were obtained when MSNA was expressed as bursts/100 heart beats. Multiple linear regression analysis revealed that only age and smoking status were linked independently to MSNA (R 2=0.42, p< 0.001). Conclusions. In patients with essential hypertension, smoking is independently associated with chronic increase in MSNA. These findings may have implications for our understanding of the mechanisms linking smoking to cardiovascular events.",
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N2 - Objective. Previous studies have shown that smoking contributes importantly to short-term modulation of sympathetic nerve traffic. However, effect of smoking status on resting muscle sympathetic nerve activity (MSNA) in hypertension is unknown. Therefore, we tested the hypothesis that smoking is associated with chronic sympathetic activation in patients with essential hypertension. Methods. We measured MSNA, heart rate (HR) and blood pressure during undisturbed supine rest and in 30 hypertensive smokers (22 males, age 38±4 years, body mass index, BMI 27±1 kg/m 2, mean±SEM). These measurements were compared with those obtained 38 non-smoking hypertensive patients matched for gender, age and BMI. All hypertensives underwent 24-h ambulatory blood pressure monitoring. Patients were newly diagnosed, never treated for hypertension and were free of any other known diseases. Results. In comparison with non-smokers, smokers had smaller officedaytime systolic blood pressure difference (6±2 vs 15±3 mmHg, respectively; p<0.01). Despite similar resting values, HR in smokers was greater than in non-smokers during both daytime (86±3 vs 77±2 beats/min, respectively; p< 0.001) and night-time (73±3 vs 66±2 beats/min, respectively; p<0.01). MSNA was elevated in smokers (36±3 bursts/min) compared with non-smokers (28±3 bursts/min; p<0.01). Similar results were obtained when MSNA was expressed as bursts/100 heart beats. Multiple linear regression analysis revealed that only age and smoking status were linked independently to MSNA (R 2=0.42, p< 0.001). Conclusions. In patients with essential hypertension, smoking is independently associated with chronic increase in MSNA. These findings may have implications for our understanding of the mechanisms linking smoking to cardiovascular events.

AB - Objective. Previous studies have shown that smoking contributes importantly to short-term modulation of sympathetic nerve traffic. However, effect of smoking status on resting muscle sympathetic nerve activity (MSNA) in hypertension is unknown. Therefore, we tested the hypothesis that smoking is associated with chronic sympathetic activation in patients with essential hypertension. Methods. We measured MSNA, heart rate (HR) and blood pressure during undisturbed supine rest and in 30 hypertensive smokers (22 males, age 38±4 years, body mass index, BMI 27±1 kg/m 2, mean±SEM). These measurements were compared with those obtained 38 non-smoking hypertensive patients matched for gender, age and BMI. All hypertensives underwent 24-h ambulatory blood pressure monitoring. Patients were newly diagnosed, never treated for hypertension and were free of any other known diseases. Results. In comparison with non-smokers, smokers had smaller officedaytime systolic blood pressure difference (6±2 vs 15±3 mmHg, respectively; p<0.01). Despite similar resting values, HR in smokers was greater than in non-smokers during both daytime (86±3 vs 77±2 beats/min, respectively; p< 0.001) and night-time (73±3 vs 66±2 beats/min, respectively; p<0.01). MSNA was elevated in smokers (36±3 bursts/min) compared with non-smokers (28±3 bursts/min; p<0.01). Similar results were obtained when MSNA was expressed as bursts/100 heart beats. Multiple linear regression analysis revealed that only age and smoking status were linked independently to MSNA (R 2=0.42, p< 0.001). Conclusions. In patients with essential hypertension, smoking is independently associated with chronic increase in MSNA. These findings may have implications for our understanding of the mechanisms linking smoking to cardiovascular events.

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