Smoking, blood pressure and serum albumin are major determinants of carotid atherosclerosis in dialysis patients

Lorenzo S. Malatino, Frank A. Benedetto, Francesca Mallamaci, Giovanni Tripepi, Carmine Zoccali, Saverio Parlongo, Sebastiano Cutrupi, Carmela Marino, Vincenzo Panuccio, Maurizio Garozzo, Vincenzo Candela, Ignazio Bellanuova, Alessandro Cataliotti, Francesco Rapisarda, Pasquale Fatuzzo, Grazia Bonanno, Giuseppe Seminara, Benedetta Stancanelli, Filippo Tassone, Carlo Labate

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Aim: To investigate the relationship between carotid atherosclerosis and some major cardiovascular risk factors in uremic patients on chronic dialysis. Methods: A cross-sectional study was carried out in 119 unselected dialysis patients (89 on hemodialysis and 30 on chronic ambulatory peritoneal dialysis, CAPD). Fasting blood sampling for serum lipids, albumin, hemoglobin, and echocolour-Doppler evaluation of common carotid arteries were performed in all patients (during the non-dialysis day in hemodialysis patients). In hemodialysis patients BP was measured before and after dialysis; in CAPD patients home BP values were recorded during the month before the study day. Results: Ninety-five patients had at least one plaque and 57 had at least four plaques. Thirty-eight had mild and eleven severe carotid stenosis. In multiple regression models, the mean internal diameter of carotid arteries was explained (R = 0.52, P = 0.0001) by systolic pressure (r = 0.39), serum cholesterol (r = -0.28), age (r = 0.27) and smoking (r = 0.24) while the degree of carotid stenosis was predicted (R = 0.39, P = 0.0001) by age (r = 0.36) and smoking (r = 0.25). The number of atherosclerotic plaques was explained (R = 0.51, P = 0.0001) by age (r = 0.36), smoking (r = 0.25) and pulse pressure (r = 0.20), serum albumin just failing to reach statistical significance (P = 0.06). However, serum albumin was a significant and independent predictor of the number of atherosclerotic plaques (r = -0.26) in hemodialysis patients (n = 89). Sex, diabetes, Kt/V, duration of dialysis treatment, hemoglobin, serum calcium and phosphate did not add any predictive power to the models. Conclusions: In dialysis patients arterial pressure and smoking are associated with carotid atherosclerosis. Serum albumin appears to serve as an independent predictor of carotid atherosclerosis.

Original languageEnglish (US)
Pages (from-to)256-260
Number of pages5
JournalJournal of Nephrology
Volume12
Issue number4
StatePublished - Jul 1999
Externally publishedYes

Fingerprint

Carotid Artery Diseases
Serum Albumin
Dialysis
Smoking
Blood Pressure
Serum
Renal Dialysis
Carotid Stenosis
Peritoneal Dialysis
Atherosclerotic Plaques
Hemoglobins
Common Carotid Artery
Internal Carotid Artery
Fasting
Arterial Pressure
Cross-Sectional Studies
Cholesterol
Lipids

Keywords

  • Atherosclerosis
  • End-stage renal disease
  • Hypertension
  • Serum albumin
  • Smoking

ASJC Scopus subject areas

  • Nephrology

Cite this

Malatino, L. S., Benedetto, F. A., Mallamaci, F., Tripepi, G., Zoccali, C., Parlongo, S., ... Labate, C. (1999). Smoking, blood pressure and serum albumin are major determinants of carotid atherosclerosis in dialysis patients. Journal of Nephrology, 12(4), 256-260.

Smoking, blood pressure and serum albumin are major determinants of carotid atherosclerosis in dialysis patients. / Malatino, Lorenzo S.; Benedetto, Frank A.; Mallamaci, Francesca; Tripepi, Giovanni; Zoccali, Carmine; Parlongo, Saverio; Cutrupi, Sebastiano; Marino, Carmela; Panuccio, Vincenzo; Garozzo, Maurizio; Candela, Vincenzo; Bellanuova, Ignazio; Cataliotti, Alessandro; Rapisarda, Francesco; Fatuzzo, Pasquale; Bonanno, Grazia; Seminara, Giuseppe; Stancanelli, Benedetta; Tassone, Filippo; Labate, Carlo.

In: Journal of Nephrology, Vol. 12, No. 4, 07.1999, p. 256-260.

Research output: Contribution to journalArticle

Malatino, LS, Benedetto, FA, Mallamaci, F, Tripepi, G, Zoccali, C, Parlongo, S, Cutrupi, S, Marino, C, Panuccio, V, Garozzo, M, Candela, V, Bellanuova, I, Cataliotti, A, Rapisarda, F, Fatuzzo, P, Bonanno, G, Seminara, G, Stancanelli, B, Tassone, F & Labate, C 1999, 'Smoking, blood pressure and serum albumin are major determinants of carotid atherosclerosis in dialysis patients', Journal of Nephrology, vol. 12, no. 4, pp. 256-260.
Malatino LS, Benedetto FA, Mallamaci F, Tripepi G, Zoccali C, Parlongo S et al. Smoking, blood pressure and serum albumin are major determinants of carotid atherosclerosis in dialysis patients. Journal of Nephrology. 1999 Jul;12(4):256-260.
Malatino, Lorenzo S. ; Benedetto, Frank A. ; Mallamaci, Francesca ; Tripepi, Giovanni ; Zoccali, Carmine ; Parlongo, Saverio ; Cutrupi, Sebastiano ; Marino, Carmela ; Panuccio, Vincenzo ; Garozzo, Maurizio ; Candela, Vincenzo ; Bellanuova, Ignazio ; Cataliotti, Alessandro ; Rapisarda, Francesco ; Fatuzzo, Pasquale ; Bonanno, Grazia ; Seminara, Giuseppe ; Stancanelli, Benedetta ; Tassone, Filippo ; Labate, Carlo. / Smoking, blood pressure and serum albumin are major determinants of carotid atherosclerosis in dialysis patients. In: Journal of Nephrology. 1999 ; Vol. 12, No. 4. pp. 256-260.
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abstract = "Aim: To investigate the relationship between carotid atherosclerosis and some major cardiovascular risk factors in uremic patients on chronic dialysis. Methods: A cross-sectional study was carried out in 119 unselected dialysis patients (89 on hemodialysis and 30 on chronic ambulatory peritoneal dialysis, CAPD). Fasting blood sampling for serum lipids, albumin, hemoglobin, and echocolour-Doppler evaluation of common carotid arteries were performed in all patients (during the non-dialysis day in hemodialysis patients). In hemodialysis patients BP was measured before and after dialysis; in CAPD patients home BP values were recorded during the month before the study day. Results: Ninety-five patients had at least one plaque and 57 had at least four plaques. Thirty-eight had mild and eleven severe carotid stenosis. In multiple regression models, the mean internal diameter of carotid arteries was explained (R = 0.52, P = 0.0001) by systolic pressure (r = 0.39), serum cholesterol (r = -0.28), age (r = 0.27) and smoking (r = 0.24) while the degree of carotid stenosis was predicted (R = 0.39, P = 0.0001) by age (r = 0.36) and smoking (r = 0.25). The number of atherosclerotic plaques was explained (R = 0.51, P = 0.0001) by age (r = 0.36), smoking (r = 0.25) and pulse pressure (r = 0.20), serum albumin just failing to reach statistical significance (P = 0.06). However, serum albumin was a significant and independent predictor of the number of atherosclerotic plaques (r = -0.26) in hemodialysis patients (n = 89). Sex, diabetes, Kt/V, duration of dialysis treatment, hemoglobin, serum calcium and phosphate did not add any predictive power to the models. Conclusions: In dialysis patients arterial pressure and smoking are associated with carotid atherosclerosis. Serum albumin appears to serve as an independent predictor of carotid atherosclerosis.",
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T1 - Smoking, blood pressure and serum albumin are major determinants of carotid atherosclerosis in dialysis patients

AU - Malatino, Lorenzo S.

AU - Benedetto, Frank A.

AU - Mallamaci, Francesca

AU - Tripepi, Giovanni

AU - Zoccali, Carmine

AU - Parlongo, Saverio

AU - Cutrupi, Sebastiano

AU - Marino, Carmela

AU - Panuccio, Vincenzo

AU - Garozzo, Maurizio

AU - Candela, Vincenzo

AU - Bellanuova, Ignazio

AU - Cataliotti, Alessandro

AU - Rapisarda, Francesco

AU - Fatuzzo, Pasquale

AU - Bonanno, Grazia

AU - Seminara, Giuseppe

AU - Stancanelli, Benedetta

AU - Tassone, Filippo

AU - Labate, Carlo

PY - 1999/7

Y1 - 1999/7

N2 - Aim: To investigate the relationship between carotid atherosclerosis and some major cardiovascular risk factors in uremic patients on chronic dialysis. Methods: A cross-sectional study was carried out in 119 unselected dialysis patients (89 on hemodialysis and 30 on chronic ambulatory peritoneal dialysis, CAPD). Fasting blood sampling for serum lipids, albumin, hemoglobin, and echocolour-Doppler evaluation of common carotid arteries were performed in all patients (during the non-dialysis day in hemodialysis patients). In hemodialysis patients BP was measured before and after dialysis; in CAPD patients home BP values were recorded during the month before the study day. Results: Ninety-five patients had at least one plaque and 57 had at least four plaques. Thirty-eight had mild and eleven severe carotid stenosis. In multiple regression models, the mean internal diameter of carotid arteries was explained (R = 0.52, P = 0.0001) by systolic pressure (r = 0.39), serum cholesterol (r = -0.28), age (r = 0.27) and smoking (r = 0.24) while the degree of carotid stenosis was predicted (R = 0.39, P = 0.0001) by age (r = 0.36) and smoking (r = 0.25). The number of atherosclerotic plaques was explained (R = 0.51, P = 0.0001) by age (r = 0.36), smoking (r = 0.25) and pulse pressure (r = 0.20), serum albumin just failing to reach statistical significance (P = 0.06). However, serum albumin was a significant and independent predictor of the number of atherosclerotic plaques (r = -0.26) in hemodialysis patients (n = 89). Sex, diabetes, Kt/V, duration of dialysis treatment, hemoglobin, serum calcium and phosphate did not add any predictive power to the models. Conclusions: In dialysis patients arterial pressure and smoking are associated with carotid atherosclerosis. Serum albumin appears to serve as an independent predictor of carotid atherosclerosis.

AB - Aim: To investigate the relationship between carotid atherosclerosis and some major cardiovascular risk factors in uremic patients on chronic dialysis. Methods: A cross-sectional study was carried out in 119 unselected dialysis patients (89 on hemodialysis and 30 on chronic ambulatory peritoneal dialysis, CAPD). Fasting blood sampling for serum lipids, albumin, hemoglobin, and echocolour-Doppler evaluation of common carotid arteries were performed in all patients (during the non-dialysis day in hemodialysis patients). In hemodialysis patients BP was measured before and after dialysis; in CAPD patients home BP values were recorded during the month before the study day. Results: Ninety-five patients had at least one plaque and 57 had at least four plaques. Thirty-eight had mild and eleven severe carotid stenosis. In multiple regression models, the mean internal diameter of carotid arteries was explained (R = 0.52, P = 0.0001) by systolic pressure (r = 0.39), serum cholesterol (r = -0.28), age (r = 0.27) and smoking (r = 0.24) while the degree of carotid stenosis was predicted (R = 0.39, P = 0.0001) by age (r = 0.36) and smoking (r = 0.25). The number of atherosclerotic plaques was explained (R = 0.51, P = 0.0001) by age (r = 0.36), smoking (r = 0.25) and pulse pressure (r = 0.20), serum albumin just failing to reach statistical significance (P = 0.06). However, serum albumin was a significant and independent predictor of the number of atherosclerotic plaques (r = -0.26) in hemodialysis patients (n = 89). Sex, diabetes, Kt/V, duration of dialysis treatment, hemoglobin, serum calcium and phosphate did not add any predictive power to the models. Conclusions: In dialysis patients arterial pressure and smoking are associated with carotid atherosclerosis. Serum albumin appears to serve as an independent predictor of carotid atherosclerosis.

KW - Atherosclerosis

KW - End-stage renal disease

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KW - Serum albumin

KW - Smoking

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