TY - JOUR
T1 - Smoking, blood pressure and serum albumin are major determinants of carotid atherosclerosis in dialysis patients
AU - Malatino, Lorenzo S.
AU - Benedetto, Frank A.
AU - Mallamaci, Francesca
AU - Tripepi, Giovanni
AU - Zoccali, Carmine
AU - Parlongo, Saverio
AU - Cutrupi, Sebastiano
AU - Marino, Carmela
AU - Panuccio, Vincenzo
AU - Garozzo, Maurizio
AU - Candela, Vincenzo
AU - Bellanuova, Ignazio
AU - Cataliotti, Alessandro
AU - Rapisarda, Francesco
AU - Fatuzzo, Pasquale
AU - Bonanno, Grazia
AU - Seminara, Giuseppe
AU - Stancanelli, Benedetta
AU - Tassone, Filippo
AU - Labate, Carlo
PY - 1999/7
Y1 - 1999/7
N2 - Aim: To investigate the relationship between carotid atherosclerosis and some major cardiovascular risk factors in uremic patients on chronic dialysis. Methods: A cross-sectional study was carried out in 119 unselected dialysis patients (89 on hemodialysis and 30 on chronic ambulatory peritoneal dialysis, CAPD). Fasting blood sampling for serum lipids, albumin, hemoglobin, and echocolour-Doppler evaluation of common carotid arteries were performed in all patients (during the non-dialysis day in hemodialysis patients). In hemodialysis patients BP was measured before and after dialysis; in CAPD patients home BP values were recorded during the month before the study day. Results: Ninety-five patients had at least one plaque and 57 had at least four plaques. Thirty-eight had mild and eleven severe carotid stenosis. In multiple regression models, the mean internal diameter of carotid arteries was explained (R = 0.52, P = 0.0001) by systolic pressure (r = 0.39), serum cholesterol (r = -0.28), age (r = 0.27) and smoking (r = 0.24) while the degree of carotid stenosis was predicted (R = 0.39, P = 0.0001) by age (r = 0.36) and smoking (r = 0.25). The number of atherosclerotic plaques was explained (R = 0.51, P = 0.0001) by age (r = 0.36), smoking (r = 0.25) and pulse pressure (r = 0.20), serum albumin just failing to reach statistical significance (P = 0.06). However, serum albumin was a significant and independent predictor of the number of atherosclerotic plaques (r = -0.26) in hemodialysis patients (n = 89). Sex, diabetes, Kt/V, duration of dialysis treatment, hemoglobin, serum calcium and phosphate did not add any predictive power to the models. Conclusions: In dialysis patients arterial pressure and smoking are associated with carotid atherosclerosis. Serum albumin appears to serve as an independent predictor of carotid atherosclerosis.
AB - Aim: To investigate the relationship between carotid atherosclerosis and some major cardiovascular risk factors in uremic patients on chronic dialysis. Methods: A cross-sectional study was carried out in 119 unselected dialysis patients (89 on hemodialysis and 30 on chronic ambulatory peritoneal dialysis, CAPD). Fasting blood sampling for serum lipids, albumin, hemoglobin, and echocolour-Doppler evaluation of common carotid arteries were performed in all patients (during the non-dialysis day in hemodialysis patients). In hemodialysis patients BP was measured before and after dialysis; in CAPD patients home BP values were recorded during the month before the study day. Results: Ninety-five patients had at least one plaque and 57 had at least four plaques. Thirty-eight had mild and eleven severe carotid stenosis. In multiple regression models, the mean internal diameter of carotid arteries was explained (R = 0.52, P = 0.0001) by systolic pressure (r = 0.39), serum cholesterol (r = -0.28), age (r = 0.27) and smoking (r = 0.24) while the degree of carotid stenosis was predicted (R = 0.39, P = 0.0001) by age (r = 0.36) and smoking (r = 0.25). The number of atherosclerotic plaques was explained (R = 0.51, P = 0.0001) by age (r = 0.36), smoking (r = 0.25) and pulse pressure (r = 0.20), serum albumin just failing to reach statistical significance (P = 0.06). However, serum albumin was a significant and independent predictor of the number of atherosclerotic plaques (r = -0.26) in hemodialysis patients (n = 89). Sex, diabetes, Kt/V, duration of dialysis treatment, hemoglobin, serum calcium and phosphate did not add any predictive power to the models. Conclusions: In dialysis patients arterial pressure and smoking are associated with carotid atherosclerosis. Serum albumin appears to serve as an independent predictor of carotid atherosclerosis.
KW - Atherosclerosis
KW - End-stage renal disease
KW - Hypertension
KW - Serum albumin
KW - Smoking
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M3 - Article
C2 - 10493569
AN - SCOPUS:0032881269
SN - 1121-8428
VL - 12
SP - 256
EP - 260
JO - Journal of Nephrology
JF - Journal of Nephrology
IS - 4
ER -