Smoking and pain: Pathophysiology and clinical implications

Yu Shi, Toby N. Weingarten, Carlos Bernardo Mantilla, W. Michael Hooten, David Oman Warner

Research output: Contribution to journalArticle

142 Citations (Scopus)

Abstract

Cigarette smoke, which serves as a nicotine delivery vehicle in humans, produces profound changes in physiology. Experimental studies suggest that nicotine has analgesic properties. However, epidemiologic evidence shows that smoking is a risk factor for chronic pain. The complex relationship between smoking and pain not only is of scientific interest, but also has clinical relevance in the practice of anesthesiology and pain medicine. This review will examine current knowledge regarding how acute and chronic exposure to nicotine and cigarette smoke affects acute and chronic painful conditions. It will cover the relevant pharmacology of nicotine and other ligands at the nicotinic acetylcholine receptor as related to pain, explore the association of cigarette smoking with chronic painful conditions and potential mechanisms to explain this association, and examine clinical implications for the care of smokers with pain.

Original languageEnglish (US)
Pages (from-to)977-992
Number of pages16
JournalAnesthesiology
Volume113
Issue number4
DOIs
StatePublished - Oct 2010

Fingerprint

Nicotine
Smoking
Pain
Smoke
Tobacco Products
Anesthesiology
Nicotinic Receptors
Chronic Pain
Analgesics
Medicine
Pharmacology
Ligands

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Smoking and pain : Pathophysiology and clinical implications. / Shi, Yu; Weingarten, Toby N.; Mantilla, Carlos Bernardo; Hooten, W. Michael; Warner, David Oman.

In: Anesthesiology, Vol. 113, No. 4, 10.2010, p. 977-992.

Research output: Contribution to journalArticle

Shi, Yu ; Weingarten, Toby N. ; Mantilla, Carlos Bernardo ; Hooten, W. Michael ; Warner, David Oman. / Smoking and pain : Pathophysiology and clinical implications. In: Anesthesiology. 2010 ; Vol. 113, No. 4. pp. 977-992.
@article{7a0bfc9847734c09bb9bcfd5b4daa05d,
title = "Smoking and pain: Pathophysiology and clinical implications",
abstract = "Cigarette smoke, which serves as a nicotine delivery vehicle in humans, produces profound changes in physiology. Experimental studies suggest that nicotine has analgesic properties. However, epidemiologic evidence shows that smoking is a risk factor for chronic pain. The complex relationship between smoking and pain not only is of scientific interest, but also has clinical relevance in the practice of anesthesiology and pain medicine. This review will examine current knowledge regarding how acute and chronic exposure to nicotine and cigarette smoke affects acute and chronic painful conditions. It will cover the relevant pharmacology of nicotine and other ligands at the nicotinic acetylcholine receptor as related to pain, explore the association of cigarette smoking with chronic painful conditions and potential mechanisms to explain this association, and examine clinical implications for the care of smokers with pain.",
author = "Yu Shi and Weingarten, {Toby N.} and Mantilla, {Carlos Bernardo} and Hooten, {W. Michael} and Warner, {David Oman}",
year = "2010",
month = "10",
doi = "10.1097/ALN.0b013e3181ebdaf9",
language = "English (US)",
volume = "113",
pages = "977--992",
journal = "Anesthesiology",
issn = "0003-3022",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Smoking and pain

T2 - Pathophysiology and clinical implications

AU - Shi, Yu

AU - Weingarten, Toby N.

AU - Mantilla, Carlos Bernardo

AU - Hooten, W. Michael

AU - Warner, David Oman

PY - 2010/10

Y1 - 2010/10

N2 - Cigarette smoke, which serves as a nicotine delivery vehicle in humans, produces profound changes in physiology. Experimental studies suggest that nicotine has analgesic properties. However, epidemiologic evidence shows that smoking is a risk factor for chronic pain. The complex relationship between smoking and pain not only is of scientific interest, but also has clinical relevance in the practice of anesthesiology and pain medicine. This review will examine current knowledge regarding how acute and chronic exposure to nicotine and cigarette smoke affects acute and chronic painful conditions. It will cover the relevant pharmacology of nicotine and other ligands at the nicotinic acetylcholine receptor as related to pain, explore the association of cigarette smoking with chronic painful conditions and potential mechanisms to explain this association, and examine clinical implications for the care of smokers with pain.

AB - Cigarette smoke, which serves as a nicotine delivery vehicle in humans, produces profound changes in physiology. Experimental studies suggest that nicotine has analgesic properties. However, epidemiologic evidence shows that smoking is a risk factor for chronic pain. The complex relationship between smoking and pain not only is of scientific interest, but also has clinical relevance in the practice of anesthesiology and pain medicine. This review will examine current knowledge regarding how acute and chronic exposure to nicotine and cigarette smoke affects acute and chronic painful conditions. It will cover the relevant pharmacology of nicotine and other ligands at the nicotinic acetylcholine receptor as related to pain, explore the association of cigarette smoking with chronic painful conditions and potential mechanisms to explain this association, and examine clinical implications for the care of smokers with pain.

UR - http://www.scopus.com/inward/record.url?scp=77957890928&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77957890928&partnerID=8YFLogxK

U2 - 10.1097/ALN.0b013e3181ebdaf9

DO - 10.1097/ALN.0b013e3181ebdaf9

M3 - Article

C2 - 20864835

AN - SCOPUS:77957890928

VL - 113

SP - 977

EP - 992

JO - Anesthesiology

JF - Anesthesiology

SN - 0003-3022

IS - 4

ER -