Smoking, alcohol, and coffee consumption preceding Parkinson's disease: A case-control study

M. D. Benedetti, James Howard Bower, D. M. Maraganore, S. K. McDonnell, B. J. Peterson, J. E. Ahlskog, Daniel J Schaid, Walter A Rocca

Research output: Contribution to journalArticle

175 Citations (Scopus)

Abstract

Objective: To study the association of PD with preceding smoking, alcohol, and coffee consumption using a case-control design. Methods: The authors used the medical records linkage system of the Rochester Epidemiology Project to identify 196 subjects who developed PD in Olmsted County, MN, during the years 1976 to 1995. Each incident case was matched by age (±1 year) and sex to a general population control subject. The authors reviewed the complete medical records of cases and control subjects to abstract exposure information. Results: For coffee consumption, the authors found an OR of 0.35 (95% CI = 0.16 to 0.78, p = 0.01), a dose-effect trend (p = 0.003), and a later age at PD onset in cases who drank coffee compared with those who never did (median 72 versus 64 years; p = 0.0002). The inverse association with coffee remained significant after adjustment for education, smoking, and alcohol drinking and was restricted to PD cases with onset at age < 72 years and to men. The OR for cigarette smoking was 0.69 (95% CI = 0.45 to 1.08, p = 0.1). The authors found no association between PD and alcohol consumption. Extreme or unusual behaviors such as tobacco chewing or snuff use and a diagnosis of alcoholism were significantly more common in control subjects than cases. Conclusions: These findings suggest an inverse association between coffee drinking and PD; however, this association does not imply that coffee has a direct protective effect against PD. Alternative explanations for the association should be considered.

Original languageEnglish (US)
Pages (from-to)1350-1358
Number of pages9
JournalNeurology
Volume55
Issue number9
StatePublished - Nov 14 2000

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Coffee
Alcohol Drinking
Parkinson Disease
Case-Control Studies
Smoking
Age of Onset
Medical Record Linkage
Smokeless Tobacco
Population Control
Tobacco Use
Alcoholism
Drinking
Medical Records
Epidemiology
Education

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Benedetti, M. D., Bower, J. H., Maraganore, D. M., McDonnell, S. K., Peterson, B. J., Ahlskog, J. E., ... Rocca, W. A. (2000). Smoking, alcohol, and coffee consumption preceding Parkinson's disease: A case-control study. Neurology, 55(9), 1350-1358.

Smoking, alcohol, and coffee consumption preceding Parkinson's disease : A case-control study. / Benedetti, M. D.; Bower, James Howard; Maraganore, D. M.; McDonnell, S. K.; Peterson, B. J.; Ahlskog, J. E.; Schaid, Daniel J; Rocca, Walter A.

In: Neurology, Vol. 55, No. 9, 14.11.2000, p. 1350-1358.

Research output: Contribution to journalArticle

Benedetti, MD, Bower, JH, Maraganore, DM, McDonnell, SK, Peterson, BJ, Ahlskog, JE, Schaid, DJ & Rocca, WA 2000, 'Smoking, alcohol, and coffee consumption preceding Parkinson's disease: A case-control study', Neurology, vol. 55, no. 9, pp. 1350-1358.
Benedetti MD, Bower JH, Maraganore DM, McDonnell SK, Peterson BJ, Ahlskog JE et al. Smoking, alcohol, and coffee consumption preceding Parkinson's disease: A case-control study. Neurology. 2000 Nov 14;55(9):1350-1358.
Benedetti, M. D. ; Bower, James Howard ; Maraganore, D. M. ; McDonnell, S. K. ; Peterson, B. J. ; Ahlskog, J. E. ; Schaid, Daniel J ; Rocca, Walter A. / Smoking, alcohol, and coffee consumption preceding Parkinson's disease : A case-control study. In: Neurology. 2000 ; Vol. 55, No. 9. pp. 1350-1358.
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