Small-vessel vasculitis

Antonio Iglesias-Gamarra, José Félix Restrepo, Eric L. Matteson

Research output: Contribution to journalReview article

11 Scopus citations

Abstract

Small-vessel vasculitis is a convenient descriptor for a wide range of diseases characterized by vascular inflammation of the venules, capillaries, and/or arterioles with pleomorphic clinical manifestations. The classical clinical phenotype is leukocytoclastic vasculitis with palpable purpura, but manifestations vary widely depending upon the organs involved. Histopathologic examination in leukocytoclastic vasculitis reveals angiocentric segmental inflammation, fibrinoid necrosis, and a neutrophilic infiltrate around the blood vessel walls with erythrocyte extravasation. The etiology of small-vessel vasculitis is unknown in many cases, but in others, drugs, post viral syndromes, malignancy, primary vasculitis such as microscopic polyarteritis, and connective tissue disorders are associated. The diagnosis of small-vessel vasculitis relies on a thorough history and physical examination, as well as relevant antibody testing including antinuclear antibody and antineutrophil cytoplasmic antibody, hepatitis B and C serologies, assessment of complement, immunoglobulins, blood count, serum creatinine, liver function tests, urinalysis, radiographic imaging, and biopsy.

Original languageEnglish (US)
Pages (from-to)304-311
Number of pages8
JournalCurrent rheumatology reports
Volume9
Issue number4
DOIs
StatePublished - Aug 2007

ASJC Scopus subject areas

  • Rheumatology

Fingerprint Dive into the research topics of 'Small-vessel vasculitis'. Together they form a unique fingerprint.

  • Cite this