TY - JOUR
T1 - Small intestinal bacterial overgrowth and nonalcoholic fatty liver disease
T2 - A systematic review and meta-analysis
AU - Wijarnpreecha, Karn
AU - Lou, Susan
AU - Watthanasuntorn, Kanramon
AU - Kroner, Paul T.
AU - Cheungpasitporn, Wisit
AU - Lukens, Frank J.
AU - Pungpapong, Surakit
AU - Keaveny, Andrew P.
AU - Ungprasert, Patompong
N1 - Publisher Copyright:
© 2020 Lippincott Williams and Wilkins. All rights reserved.
PY - 2020/5/1
Y1 - 2020/5/1
N2 - Objectives Recent studies have suggested that small intestinal bacterial overgrowth (SIBO) could be a predisposing factor for nonalcoholic fatty liver disease (NAFLD) although the results were inconsistent. This systematic review and meta-analysis was conducted with the aim to summarize all available data. Methods A comprehensive literature review was conducted utilizing MEDLINE and EMBASE databases through September 2018 to identify all studies that compared the risk of NAFLD among patients with SIBO versus those without SIBO. Effect estimates from each study were extracted and combined together using the random effect, generic inverse variance method of DerSimonian and Laird. Results A total of 10 studies with 1093 participants fulfilled the eligibility criteria and were included in the meta-analysis. A significant association between NAFLD and SIBO was observed with the pooled odds ratio of 3.82 (95% confidence interval, 1.93-7.59; I265%). Funnel plot is relatively symmetric and is not suggestive of the presence of publication bias. Conclusion A significant association between NAFLD and SIBO was observed in this meta-analysis.
AB - Objectives Recent studies have suggested that small intestinal bacterial overgrowth (SIBO) could be a predisposing factor for nonalcoholic fatty liver disease (NAFLD) although the results were inconsistent. This systematic review and meta-analysis was conducted with the aim to summarize all available data. Methods A comprehensive literature review was conducted utilizing MEDLINE and EMBASE databases through September 2018 to identify all studies that compared the risk of NAFLD among patients with SIBO versus those without SIBO. Effect estimates from each study were extracted and combined together using the random effect, generic inverse variance method of DerSimonian and Laird. Results A total of 10 studies with 1093 participants fulfilled the eligibility criteria and were included in the meta-analysis. A significant association between NAFLD and SIBO was observed with the pooled odds ratio of 3.82 (95% confidence interval, 1.93-7.59; I265%). Funnel plot is relatively symmetric and is not suggestive of the presence of publication bias. Conclusion A significant association between NAFLD and SIBO was observed in this meta-analysis.
KW - bacterial overgrowth
KW - malabsorption
KW - meta-analysis
KW - nonalcoholic fatty liver disease
KW - nonalcoholic steatohepatitis
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U2 - 10.1097/MEG.0000000000001541
DO - 10.1097/MEG.0000000000001541
M3 - Review article
C2 - 31567712
AN - SCOPUS:85083041330
SN - 0954-691X
VL - 32
SP - 601
EP - 608
JO - European Journal of Gastroenterology and Hepatology
JF - European Journal of Gastroenterology and Hepatology
IS - 5
ER -