Small intestinal adenocarcinoma in Crohn's disease: A case-control study

Craig A. Solem, W. Scott Harmsen, Alan R. Zinsmeister, Edward Vincent Loftus, Jr

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

Background: Small bowel adenocarcinoma is an uncommon complication of Crohn's disease. We sought to describe the clinical features, outcomes, and risk factors of small bowel adenocarcinoma in Crohn's disease. Methods: A centralized diagnostic index identified all patients with Crohn's disease with small bowel adenocarcinoma evaluated at our institution between 1976 and 2000, and the medical records were abstracted. Two controls with Crohn's disease were selected for each case, matched by gender and age. Results: Nine cases (four males) were identified. The patients presented with abdominal pain (89%), obstruction (89%), and weight loss (78%). Cancer was located in the ileum in 8 patients (89%) and the jejunum in 1 patient (11%). All cases but 1 had either lymph node involvement or metastasis. All cases had surgery, with 1 receiving adjuvant chemotherapy. No significant risk factors were found. The mortality rates at 1 and 2 years were 42% and 61%. Conclusions: Small bowel adenocarcinoma is a rare complication of Crohn's disease that typically involves the ileum. Affected patients have symptomatic, advanced malignancies upon diagnosis. No significant risk factors were identified.

Original languageEnglish (US)
Pages (from-to)32-35
Number of pages4
JournalInflammatory Bowel Diseases
Volume10
Issue number1
DOIs
StatePublished - Jan 2004

Fingerprint

Crohn Disease
Case-Control Studies
Adenocarcinoma
Ileum
Jejunum
Adjuvant Chemotherapy
Abdominal Pain
Medical Records
Weight Loss
Neoplasms
Lymph Nodes
Neoplasm Metastasis
Mortality

Keywords

  • 5-aminosalicylic acid
  • Crohn's disease
  • Fistulas
  • Small bowel adenocarcinoma

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Small intestinal adenocarcinoma in Crohn's disease : A case-control study. / Solem, Craig A.; Harmsen, W. Scott; Zinsmeister, Alan R.; Loftus, Jr, Edward Vincent.

In: Inflammatory Bowel Diseases, Vol. 10, No. 1, 01.2004, p. 32-35.

Research output: Contribution to journalArticle

Solem, Craig A. ; Harmsen, W. Scott ; Zinsmeister, Alan R. ; Loftus, Jr, Edward Vincent. / Small intestinal adenocarcinoma in Crohn's disease : A case-control study. In: Inflammatory Bowel Diseases. 2004 ; Vol. 10, No. 1. pp. 32-35.
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