Small fibre involvement in neuropathy associated with IgG, IgA and IgM monoclonal gammopathy

S. Barbieri, P. Sandroni, E. Nobile-Orazio, A. Cappellari, C. Cavestro, L. Baldini, G. Scarlato

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

A delta and C fibre function has been investigated in 18 patients affected by neuropathies associated with monoclonal gammopathies. Warm, cold and heat pain thresholds have been determined by means of a Somedic Thermotest, operating on the Peltier principle, in a room at constant temperature. Our results indicate that: 1) there is an involvement of A delta and C fibres in these neuropathies that might be difficult to quantitate only on clinical grounds 2) in IgG and IgA patients, all affected by a subclinical or mild axonal neuropathy, small fibres of both types are always involved 3) in IgM anti-MAG positive severe cases, A delta fibre involvement suggestive of demyelination is evident, while in one anti-MAG negative patient only C fibres are damaged, probably reflecting a different pathogenetic mechanism.

Original languageEnglish (US)
Pages (from-to)39-44
Number of pages6
JournalElectromyography and Clinical Neurophysiology
Volume35
Issue number1
StatePublished - Jan 1 1995

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Physiology (medical)

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    Barbieri, S., Sandroni, P., Nobile-Orazio, E., Cappellari, A., Cavestro, C., Baldini, L., & Scarlato, G. (1995). Small fibre involvement in neuropathy associated with IgG, IgA and IgM monoclonal gammopathy. Electromyography and Clinical Neurophysiology, 35(1), 39-44.