Slowing gait speed precedes cognitive decline by several years

Tobias Skillbäck; Kaj Blennow; Henrik Zetterberg; Johan Skoog; Lina Rydén; Hanna Wetterberg; Xinxin Guo; Simona Sacuiu; Michelle M. Mielke; Anna Zettergren; Ingmar Skoog; Silke Kern

doi:10.1002/alz.12537

Slowing gait speed precedes cognitive decline by several years

Tobias Skillbäck, Kaj Blennow, Henrik Zetterberg, Johan Skoog, Lina Rydén, Hanna Wetterberg, Xinxin Guo, Simona Sacuiu, Michelle M. Mielke, Anna Zettergren, Ingmar Skoog, Silke Kern

Quantitative Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Introduction: In this longitudinal study, we aimed to examine if slowing gait speed preceded cognitive decline and correlated with brain amyloidosis. Methods: The sample (n = 287) was derived from the Gothenburg H70 Birth Cohort Studies, with follow-ups between 2000 and 2015. Gait speed was measured by indoor walk, and cognition using the Clinical Dementia Rating (CDR) score. All participants had CDR = 0 at baseline. Some participants had data on cerebrospinal fluid (CSF) amyloid beta (Aβ)_1-42 concentrations at the 2009 examination. Results: Gait speed for participants who worsened in CDR score during follow-up was slower at most examinations. Baseline gait speed could significantly predict CDR change from baseline to follow-up. Subjects with pathological CSF Aβ_1-₄₂ concentrations at the 2009 visit had lost more gait speed compared to previous examinations. Discussion: Our results indicate that gait speed decline precedes cognitive decline, is linked to Alzheimer's pathology, and might be used for early detection of increased risk for dementia development.

Original language	English (US)
Pages (from-to)	1667-1676
Number of pages	10
Journal	Alzheimer's and Dementia
Volume	18
Issue number	9
DOIs	https://doi.org/10.1002/alz.12537
State	Published - Sep 2022

Keywords

Alzheimer's disease
Aβ42
CSF
cognitive decline
gait
motor function

ASJC Scopus subject areas

Epidemiology
Health Policy
Developmental Neuroscience
Clinical Neurology
Geriatrics and Gerontology
Cellular and Molecular Neuroscience
Psychiatry and Mental health

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10.1002/alz.12537

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title = "Slowing gait speed precedes cognitive decline by several years",

abstract = "Introduction: In this longitudinal study, we aimed to examine if slowing gait speed preceded cognitive decline and correlated with brain amyloidosis. Methods: The sample (n = 287) was derived from the Gothenburg H70 Birth Cohort Studies, with follow-ups between 2000 and 2015. Gait speed was measured by indoor walk, and cognition using the Clinical Dementia Rating (CDR) score. All participants had CDR = 0 at baseline. Some participants had data on cerebrospinal fluid (CSF) amyloid beta (Aβ)1-42 concentrations at the 2009 examination. Results: Gait speed for participants who worsened in CDR score during follow-up was slower at most examinations. Baseline gait speed could significantly predict CDR change from baseline to follow-up. Subjects with pathological CSF Aβ1-42 concentrations at the 2009 visit had lost more gait speed compared to previous examinations. Discussion: Our results indicate that gait speed decline precedes cognitive decline, is linked to Alzheimer's pathology, and might be used for early detection of increased risk for dementia development.",

keywords = "Alzheimer's disease, Aβ42, CSF, cognitive decline, gait, motor function",

author = "Tobias Skillb{\"a}ck and Kaj Blennow and Henrik Zetterberg and Johan Skoog and Lina Ryd{\'e}n and Hanna Wetterberg and Xinxin Guo and Simona Sacuiu and Mielke, {Michelle M.} and Anna Zettergren and Ingmar Skoog and Silke Kern",

note = "Publisher Copyright: {\textcopyright} 2021 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.",

year = "2022",

month = sep,

doi = "10.1002/alz.12537",

language = "English (US)",

volume = "18",

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AU - Skillbäck, Tobias

AU - Blennow, Kaj

AU - Zetterberg, Henrik

AU - Skoog, Johan

AU - Rydén, Lina

AU - Wetterberg, Hanna

AU - Guo, Xinxin

AU - Sacuiu, Simona

AU - Mielke, Michelle M.

AU - Zettergren, Anna

AU - Skoog, Ingmar

AU - Kern, Silke

PY - 2022/9

Y1 - 2022/9

N2 - Introduction: In this longitudinal study, we aimed to examine if slowing gait speed preceded cognitive decline and correlated with brain amyloidosis. Methods: The sample (n = 287) was derived from the Gothenburg H70 Birth Cohort Studies, with follow-ups between 2000 and 2015. Gait speed was measured by indoor walk, and cognition using the Clinical Dementia Rating (CDR) score. All participants had CDR = 0 at baseline. Some participants had data on cerebrospinal fluid (CSF) amyloid beta (Aβ)1-42 concentrations at the 2009 examination. Results: Gait speed for participants who worsened in CDR score during follow-up was slower at most examinations. Baseline gait speed could significantly predict CDR change from baseline to follow-up. Subjects with pathological CSF Aβ1-42 concentrations at the 2009 visit had lost more gait speed compared to previous examinations. Discussion: Our results indicate that gait speed decline precedes cognitive decline, is linked to Alzheimer's pathology, and might be used for early detection of increased risk for dementia development.

AB - Introduction: In this longitudinal study, we aimed to examine if slowing gait speed preceded cognitive decline and correlated with brain amyloidosis. Methods: The sample (n = 287) was derived from the Gothenburg H70 Birth Cohort Studies, with follow-ups between 2000 and 2015. Gait speed was measured by indoor walk, and cognition using the Clinical Dementia Rating (CDR) score. All participants had CDR = 0 at baseline. Some participants had data on cerebrospinal fluid (CSF) amyloid beta (Aβ)1-42 concentrations at the 2009 examination. Results: Gait speed for participants who worsened in CDR score during follow-up was slower at most examinations. Baseline gait speed could significantly predict CDR change from baseline to follow-up. Subjects with pathological CSF Aβ1-42 concentrations at the 2009 visit had lost more gait speed compared to previous examinations. Discussion: Our results indicate that gait speed decline precedes cognitive decline, is linked to Alzheimer's pathology, and might be used for early detection of increased risk for dementia development.

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KW - CSF

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KW - motor function

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Slowing gait speed precedes cognitive decline by several years

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