Abstract
Purpose: To investigate the ability of slip interface imaging (SII), a recently developed magnetic resonance elastography (MRE)-based technique, to predict the degree of meningioma-brain adhesion, using findings at surgery as the reference standard. Materials and Methods: With Institutional Review Board approval and written informed consent, 25 patients with meningiomas >2.5cm in maximal diameter underwent preoperative SII assessment. Intracranial shear motions were introduced using a soft, pillow-like head driver and the resulting displacement field was acquired with an MRE pulse sequence on 3T MR scanners. The displacement data were analyzed to determine tumor-brain adhesion by assessing intensities on shear line images and raw as well as normalized octahedral shear strain (OSS) values along the interface. The SII findings of shear line images, OSS, and normalized OSS were independently and blindly correlated with surgical findings of tumor adhesion by using the Cohen's κ coefficient and chi-squared test. Results: Neurosurgeons categorized the surgical plane as extrapial (no adhesion) in 15 patients, mixed in four, and subpial (adhesion) in six. Both shear line images and OSS agreed with the surgical findings in 18 (72%) cases (fair agreement, κ=0.37, 95% confidence interval [CI]: 0.05-0.69), while normalized OSS was concordant with the surgical findings in 23 (92%) cases (good agreement, κ=0.86, 95% CI: 0.67-1). The correlation between SII predictions (shear line images, OSS, and normalized OSS) and the surgical findings were statistically significant (chi-squared test, P=0.02, P=0.02, and P < 0.0001, respectively). Conclusion: SII preoperatively evaluates the degree of meningioma-brain adhesion noninvasively, allowing for improved prediction of surgical risk and tumor resectability.
| Original language | English (US) |
|---|---|
| Journal | Journal of Magnetic Resonance Imaging |
| DOIs | |
| State | Accepted/In press - 2017 |
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Keywords
- Magnetic resonance elastography
- Meningioma
- Octahedral shear strain
- Slip interface imaging
- Surgical plane
- Tumor-brain adhesion
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
Cite this
Slip interface imaging based on MR-elastography preoperatively predicts meningioma-brain adhesion. / Yin, Ziying; Hughes, Joshua D.; Glaser, Kevin J.; Manduca, Armando; Van Gompel, Jamie; Link, Michael J.; Romano, Anthony; Ehman, Richard Lorne; Huston, John III.
In: Journal of Magnetic Resonance Imaging, 2017.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Slip interface imaging based on MR-elastography preoperatively predicts meningioma-brain adhesion
AU - Yin, Ziying
AU - Hughes, Joshua D.
AU - Glaser, Kevin J.
AU - Manduca, Armando
AU - Van Gompel, Jamie
AU - Link, Michael J.
AU - Romano, Anthony
AU - Ehman, Richard Lorne
AU - Huston, John III
PY - 2017
Y1 - 2017
N2 - Purpose: To investigate the ability of slip interface imaging (SII), a recently developed magnetic resonance elastography (MRE)-based technique, to predict the degree of meningioma-brain adhesion, using findings at surgery as the reference standard. Materials and Methods: With Institutional Review Board approval and written informed consent, 25 patients with meningiomas >2.5cm in maximal diameter underwent preoperative SII assessment. Intracranial shear motions were introduced using a soft, pillow-like head driver and the resulting displacement field was acquired with an MRE pulse sequence on 3T MR scanners. The displacement data were analyzed to determine tumor-brain adhesion by assessing intensities on shear line images and raw as well as normalized octahedral shear strain (OSS) values along the interface. The SII findings of shear line images, OSS, and normalized OSS were independently and blindly correlated with surgical findings of tumor adhesion by using the Cohen's κ coefficient and chi-squared test. Results: Neurosurgeons categorized the surgical plane as extrapial (no adhesion) in 15 patients, mixed in four, and subpial (adhesion) in six. Both shear line images and OSS agreed with the surgical findings in 18 (72%) cases (fair agreement, κ=0.37, 95% confidence interval [CI]: 0.05-0.69), while normalized OSS was concordant with the surgical findings in 23 (92%) cases (good agreement, κ=0.86, 95% CI: 0.67-1). The correlation between SII predictions (shear line images, OSS, and normalized OSS) and the surgical findings were statistically significant (chi-squared test, P=0.02, P=0.02, and P < 0.0001, respectively). Conclusion: SII preoperatively evaluates the degree of meningioma-brain adhesion noninvasively, allowing for improved prediction of surgical risk and tumor resectability.
AB - Purpose: To investigate the ability of slip interface imaging (SII), a recently developed magnetic resonance elastography (MRE)-based technique, to predict the degree of meningioma-brain adhesion, using findings at surgery as the reference standard. Materials and Methods: With Institutional Review Board approval and written informed consent, 25 patients with meningiomas >2.5cm in maximal diameter underwent preoperative SII assessment. Intracranial shear motions were introduced using a soft, pillow-like head driver and the resulting displacement field was acquired with an MRE pulse sequence on 3T MR scanners. The displacement data were analyzed to determine tumor-brain adhesion by assessing intensities on shear line images and raw as well as normalized octahedral shear strain (OSS) values along the interface. The SII findings of shear line images, OSS, and normalized OSS were independently and blindly correlated with surgical findings of tumor adhesion by using the Cohen's κ coefficient and chi-squared test. Results: Neurosurgeons categorized the surgical plane as extrapial (no adhesion) in 15 patients, mixed in four, and subpial (adhesion) in six. Both shear line images and OSS agreed with the surgical findings in 18 (72%) cases (fair agreement, κ=0.37, 95% confidence interval [CI]: 0.05-0.69), while normalized OSS was concordant with the surgical findings in 23 (92%) cases (good agreement, κ=0.86, 95% CI: 0.67-1). The correlation between SII predictions (shear line images, OSS, and normalized OSS) and the surgical findings were statistically significant (chi-squared test, P=0.02, P=0.02, and P < 0.0001, respectively). Conclusion: SII preoperatively evaluates the degree of meningioma-brain adhesion noninvasively, allowing for improved prediction of surgical risk and tumor resectability.
KW - Magnetic resonance elastography
KW - Meningioma
KW - Octahedral shear strain
KW - Slip interface imaging
KW - Surgical plane
KW - Tumor-brain adhesion
UR - http://www.scopus.com/inward/record.url?scp=85013058439&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85013058439&partnerID=8YFLogxK
U2 - 10.1002/jmri.25623
DO - 10.1002/jmri.25623
M3 - Article
C2 - 28194925
AN - SCOPUS:85013058439
JO - Journal of Magnetic Resonance Imaging
JF - Journal of Magnetic Resonance Imaging
SN - 1053-1807
ER -