Sleeping beauty models of cancer

Jesse D. Riordan, Laura M. Rogers, Katherine E. Berquam-Vrieze, Adam J. Dupuy

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The many advantages of retroviral insertional mutagenesis have been discussed in the previous chapters, and this strategy has played a significant role in furthering our current understanding of the genetic basis of cancer. However, retroviral insertional mutagenesis has two main limitations that have prevented this approach from being applied to many forms of cancer. First, naturally-occurring slow transforming retroviruses have a restricted cellular tropism within the infected host, thus limiting the types of cells that can be mutagenized by these viruses [29]. Second, retroviruses require the host cell to undergo mitosis in order to gain access to the nuclear genome and integrate as a provirus. The combined effects of these drawbacks have limited the application of retroviral insertional mutagenesis to the study of hematopoietic malignancies and mammary cancer in mice.

Original languageEnglish (US)
Title of host publicationInsertional Mutagenesis Strategies in Cancer Genetics
PublisherSpringer New York
Pages113-130
Number of pages18
ISBN (Print)9781441976550
DOIs
StatePublished - 2011

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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