Sleep disturbances in the speech-language variant of progressive supranuclear palsy

Fatma Ozlem Hokelekli, Farwa Ali, Arenn F. Carlos, Peter R. Martin, Heather M. Clark, Joseph R. Duffy, Rene L. Utianski, Hugo Botha, Erik K. St Louis, Jennifer L. Whitwell, Keith A. Josephs

Research output: Contribution to journalArticlepeer-review


Introduction: Progressive supranuclear palsy (PSP) variants other than PSP-Richardson Syndrome (PSP-RS) have been recognized, including PSP with speech and language problems (PSP-SL). Given the reported sleep disruptions in PSP-RS, we investigated sleep abnormalities in PSP-SL. Methods: Four sleep-related screening questions were given to the caregivers of 90 patients with PSP-SL (59 suggestive of PSP-SL and 31 possible PSP-SL) and 71 probable PSP-RS (prob. PSP-RS) patients. Results: At least one sleep-related disturbance was observed in 35.6% of suggestive of PSP-SL, 38.7% of possible PSP-SL, and 67.6% of prob. PSP-RS, the most common being “unable to fall or stay asleep”. Prob. PSP-RS showed higher frequency of “screaming or talking in sleep”, “acting out dreams”, and “unable to fall or stay asleep” compared to both PSP-SL groups, but did not differ from possible PSP-SL in “excessive daytime sleepiness”. Conclusion: Sleep abnormalities are common in PSP-SL, but less frequent than prob.PSP-RS.

Original languageEnglish (US)
Pages (from-to)9-12
Number of pages4
JournalParkinsonism and Related Disorders
StatePublished - Oct 2021


  • Language
  • PSP-RS
  • PSP-SL
  • Progressive supranuclear palsy
  • Speech

ASJC Scopus subject areas

  • Neurology
  • Geriatrics and Gerontology
  • Clinical Neurology


Dive into the research topics of 'Sleep disturbances in the speech-language variant of progressive supranuclear palsy'. Together they form a unique fingerprint.

Cite this