Sleep-disordered breathing in patients with the Brugada syndrome

Paula G. MacEdo, Josep Brugada, Pavel Leinveber, Begoña Benito, Irma Molina, Fatima Sert-Kuniyoshi, Taro Adachi, Jan Bukartyk, Christelle Van Der Walt, Tomas Konecny, Shantal Maharaj, Tomas Kara, Josep Montserrat, Virend Somers

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

We investigated breathing patterns and the occurrence of arrhythmias and ST-segment changes during sleep in patients with Brugada syndrome. Patients with Brugada syndrome are more likely to die from ventricular arrhythmias during sleep. ST-segment changes have been correlated with risk of sudden cardiac death. Whether sleep disturbances may contribute to arrhythmogenesis is unknown. Patients with Brugada syndrome underwent overnight polysomnography with simultaneous 12-lead electrocardiographic recording. A control group matched by age, gender, and body mass index (BMI) also underwent polysomnography. Twenty patients were included (50 ± 15 years old, 75% men). Despite their normal BMI (24.7 ± 2.7 kg/m2), 45% had sleep-disordered breathing (SDB), with a mean apnea-hypopnea index of 17.2 ± 14 events/hour. In patients with a high risk of arrhythmias, 5 (63%) had SDB. In the control group, 27% had SDB. Atrial or ventricular arrhythmias were not observed. Spontaneous ST-segment changes occurred in 2 patients over 45 different time points. Most ST-segment changes were observed during rapid eye movement sleep (31%) or within 1 minute of arousals (44%). Regarding respiratory events, 25 (56%) of ST-segment changes were related to occurrence of apnea or hypopnea. In conclusion, patients with Brugada syndrome have a high prevalence of SDB even in the setting of normal BMI. The higher incidence of nocturnal death in patients with Brugada syndrome may be conceivably related to co-morbid SDB. Moreover, autonomic instability encountered in rapid eye movement sleep and arousals could potentiate the risk of arrhythmias.

Original languageEnglish (US)
Pages (from-to)709-713
Number of pages5
JournalAmerican Journal of Cardiology
Volume107
Issue number5
DOIs
StatePublished - Mar 1 2011

Fingerprint

Brugada Syndrome
Sleep Apnea Syndromes
Cardiac Arrhythmias
Sleep
Body Mass Index
Polysomnography
REM Sleep
Apnea
Arousal
Control Groups
Sudden Cardiac Death
Respiration
Incidence

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

MacEdo, P. G., Brugada, J., Leinveber, P., Benito, B., Molina, I., Sert-Kuniyoshi, F., ... Somers, V. (2011). Sleep-disordered breathing in patients with the Brugada syndrome. American Journal of Cardiology, 107(5), 709-713. https://doi.org/10.1016/j.amjcard.2010.10.046

Sleep-disordered breathing in patients with the Brugada syndrome. / MacEdo, Paula G.; Brugada, Josep; Leinveber, Pavel; Benito, Begoña; Molina, Irma; Sert-Kuniyoshi, Fatima; Adachi, Taro; Bukartyk, Jan; Van Der Walt, Christelle; Konecny, Tomas; Maharaj, Shantal; Kara, Tomas; Montserrat, Josep; Somers, Virend.

In: American Journal of Cardiology, Vol. 107, No. 5, 01.03.2011, p. 709-713.

Research output: Contribution to journalArticle

MacEdo, PG, Brugada, J, Leinveber, P, Benito, B, Molina, I, Sert-Kuniyoshi, F, Adachi, T, Bukartyk, J, Van Der Walt, C, Konecny, T, Maharaj, S, Kara, T, Montserrat, J & Somers, V 2011, 'Sleep-disordered breathing in patients with the Brugada syndrome', American Journal of Cardiology, vol. 107, no. 5, pp. 709-713. https://doi.org/10.1016/j.amjcard.2010.10.046
MacEdo PG, Brugada J, Leinveber P, Benito B, Molina I, Sert-Kuniyoshi F et al. Sleep-disordered breathing in patients with the Brugada syndrome. American Journal of Cardiology. 2011 Mar 1;107(5):709-713. https://doi.org/10.1016/j.amjcard.2010.10.046
MacEdo, Paula G. ; Brugada, Josep ; Leinveber, Pavel ; Benito, Begoña ; Molina, Irma ; Sert-Kuniyoshi, Fatima ; Adachi, Taro ; Bukartyk, Jan ; Van Der Walt, Christelle ; Konecny, Tomas ; Maharaj, Shantal ; Kara, Tomas ; Montserrat, Josep ; Somers, Virend. / Sleep-disordered breathing in patients with the Brugada syndrome. In: American Journal of Cardiology. 2011 ; Vol. 107, No. 5. pp. 709-713.
@article{074d213b17634c9bb1e2aca9839faeb2,
title = "Sleep-disordered breathing in patients with the Brugada syndrome",
abstract = "We investigated breathing patterns and the occurrence of arrhythmias and ST-segment changes during sleep in patients with Brugada syndrome. Patients with Brugada syndrome are more likely to die from ventricular arrhythmias during sleep. ST-segment changes have been correlated with risk of sudden cardiac death. Whether sleep disturbances may contribute to arrhythmogenesis is unknown. Patients with Brugada syndrome underwent overnight polysomnography with simultaneous 12-lead electrocardiographic recording. A control group matched by age, gender, and body mass index (BMI) also underwent polysomnography. Twenty patients were included (50 ± 15 years old, 75{\%} men). Despite their normal BMI (24.7 ± 2.7 kg/m2), 45{\%} had sleep-disordered breathing (SDB), with a mean apnea-hypopnea index of 17.2 ± 14 events/hour. In patients with a high risk of arrhythmias, 5 (63{\%}) had SDB. In the control group, 27{\%} had SDB. Atrial or ventricular arrhythmias were not observed. Spontaneous ST-segment changes occurred in 2 patients over 45 different time points. Most ST-segment changes were observed during rapid eye movement sleep (31{\%}) or within 1 minute of arousals (44{\%}). Regarding respiratory events, 25 (56{\%}) of ST-segment changes were related to occurrence of apnea or hypopnea. In conclusion, patients with Brugada syndrome have a high prevalence of SDB even in the setting of normal BMI. The higher incidence of nocturnal death in patients with Brugada syndrome may be conceivably related to co-morbid SDB. Moreover, autonomic instability encountered in rapid eye movement sleep and arousals could potentiate the risk of arrhythmias.",
author = "MacEdo, {Paula G.} and Josep Brugada and Pavel Leinveber and Bego{\~n}a Benito and Irma Molina and Fatima Sert-Kuniyoshi and Taro Adachi and Jan Bukartyk and {Van Der Walt}, Christelle and Tomas Konecny and Shantal Maharaj and Tomas Kara and Josep Montserrat and Virend Somers",
year = "2011",
month = "3",
day = "1",
doi = "10.1016/j.amjcard.2010.10.046",
language = "English (US)",
volume = "107",
pages = "709--713",
journal = "American Journal of Cardiology",
issn = "0002-9149",
publisher = "Elsevier Inc.",
number = "5",

}

TY - JOUR

T1 - Sleep-disordered breathing in patients with the Brugada syndrome

AU - MacEdo, Paula G.

AU - Brugada, Josep

AU - Leinveber, Pavel

AU - Benito, Begoña

AU - Molina, Irma

AU - Sert-Kuniyoshi, Fatima

AU - Adachi, Taro

AU - Bukartyk, Jan

AU - Van Der Walt, Christelle

AU - Konecny, Tomas

AU - Maharaj, Shantal

AU - Kara, Tomas

AU - Montserrat, Josep

AU - Somers, Virend

PY - 2011/3/1

Y1 - 2011/3/1

N2 - We investigated breathing patterns and the occurrence of arrhythmias and ST-segment changes during sleep in patients with Brugada syndrome. Patients with Brugada syndrome are more likely to die from ventricular arrhythmias during sleep. ST-segment changes have been correlated with risk of sudden cardiac death. Whether sleep disturbances may contribute to arrhythmogenesis is unknown. Patients with Brugada syndrome underwent overnight polysomnography with simultaneous 12-lead electrocardiographic recording. A control group matched by age, gender, and body mass index (BMI) also underwent polysomnography. Twenty patients were included (50 ± 15 years old, 75% men). Despite their normal BMI (24.7 ± 2.7 kg/m2), 45% had sleep-disordered breathing (SDB), with a mean apnea-hypopnea index of 17.2 ± 14 events/hour. In patients with a high risk of arrhythmias, 5 (63%) had SDB. In the control group, 27% had SDB. Atrial or ventricular arrhythmias were not observed. Spontaneous ST-segment changes occurred in 2 patients over 45 different time points. Most ST-segment changes were observed during rapid eye movement sleep (31%) or within 1 minute of arousals (44%). Regarding respiratory events, 25 (56%) of ST-segment changes were related to occurrence of apnea or hypopnea. In conclusion, patients with Brugada syndrome have a high prevalence of SDB even in the setting of normal BMI. The higher incidence of nocturnal death in patients with Brugada syndrome may be conceivably related to co-morbid SDB. Moreover, autonomic instability encountered in rapid eye movement sleep and arousals could potentiate the risk of arrhythmias.

AB - We investigated breathing patterns and the occurrence of arrhythmias and ST-segment changes during sleep in patients with Brugada syndrome. Patients with Brugada syndrome are more likely to die from ventricular arrhythmias during sleep. ST-segment changes have been correlated with risk of sudden cardiac death. Whether sleep disturbances may contribute to arrhythmogenesis is unknown. Patients with Brugada syndrome underwent overnight polysomnography with simultaneous 12-lead electrocardiographic recording. A control group matched by age, gender, and body mass index (BMI) also underwent polysomnography. Twenty patients were included (50 ± 15 years old, 75% men). Despite their normal BMI (24.7 ± 2.7 kg/m2), 45% had sleep-disordered breathing (SDB), with a mean apnea-hypopnea index of 17.2 ± 14 events/hour. In patients with a high risk of arrhythmias, 5 (63%) had SDB. In the control group, 27% had SDB. Atrial or ventricular arrhythmias were not observed. Spontaneous ST-segment changes occurred in 2 patients over 45 different time points. Most ST-segment changes were observed during rapid eye movement sleep (31%) or within 1 minute of arousals (44%). Regarding respiratory events, 25 (56%) of ST-segment changes were related to occurrence of apnea or hypopnea. In conclusion, patients with Brugada syndrome have a high prevalence of SDB even in the setting of normal BMI. The higher incidence of nocturnal death in patients with Brugada syndrome may be conceivably related to co-morbid SDB. Moreover, autonomic instability encountered in rapid eye movement sleep and arousals could potentiate the risk of arrhythmias.

UR - http://www.scopus.com/inward/record.url?scp=79951577304&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79951577304&partnerID=8YFLogxK

U2 - 10.1016/j.amjcard.2010.10.046

DO - 10.1016/j.amjcard.2010.10.046

M3 - Article

VL - 107

SP - 709

EP - 713

JO - American Journal of Cardiology

JF - American Journal of Cardiology

SN - 0002-9149

IS - 5

ER -