Sleep, death, and the heart

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Obstructive and central sleep apnea have been associated with increased risk of adverse cardiovascular events and mortality. Sympathetic dysregulation occurring as a result of the respiratory disturbance is thought to play a role in this increased risk. Sleep apnea increases the risk of arrhythmias, myocardial ischemia/infarction, stroke, and heart failure, all of which may increase mortality risk. A higher incidence of nocturnal arrhythmias, cardiac ischemia, and sudden death has been noted in subjects with sleep-disordered breathing (SDB). In this review, the association between SDB and each of these conditions is discussed, as well as the potential mechanisms underlying these risks and the effects of treatment of SDB. Particular emphasis is placed on the relationship between SDB and nocturnal atrial and ventricular arrhythmias, myocardial ischemia/infarction and sudden death.

Original languageEnglish (US)
Pages (from-to)H739-H749
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume309
Issue number5
DOIs
StatePublished - Sep 3 2015

Fingerprint

Sleep Apnea Syndromes
Sleep
Cardiac Arrhythmias
Myocardial Ischemia
Myocardial Infarction
Central Sleep Apnea
Mortality
Sudden Cardiac Death
Obstructive Sleep Apnea
Sudden Death
Ischemia
Heart Failure
Stroke
Incidence

Keywords

  • Arrhythmia
  • Cardiovascular
  • Mortality
  • Sleep apnea
  • Sleep disordered breathing

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine

Cite this

Sleep, death, and the heart. / Mansukhani, Meghna; Wang, Shihan; Somers, Virend.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 309, No. 5, 03.09.2015, p. H739-H749.

Research output: Contribution to journalArticle

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