Sleep characteristics and risk of dementia and Alzheimer's disease: The Atherosclerosis Risk in Communities Study

Pamela L. Lutsey, Jeffrey R. Misialek, Thomas H. Mosley, Rebecca F. Gottesman, Naresh M. Punjabi, Eyal Shahar, Richard MacLehose, Rachel P. Ogilvie, David S Knopman, Alvaro Alonso

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Introduction: This study tested the hypotheses that late-midlife obstructive sleep apnea (OSA) and short and long sleep duration are associated with dementia over 15 years of follow-up. Methods: A total of 1667 Atherosclerosis Risk in Communities Study participants underwent in-home polysomnography (1996-1998) and were followed for dementia. Dementia was defined by (1) hospitalization diagnosis codes (1996-2012) and (2) a comprehensive neurocognitive examination (2011-2013) with adjudication. Results: OSA and sleep duration were not associated with risk of incident dementia. When using adjudicated outcomes, severe OSA (≥30 vs. <5 apnea-hypopnea events/hour) was associated with higher risk of all-cause dementia (risk ratio [95% confidence interval], 2.35 [1.06-5.18]) and Alzheimer's disease dementia (1.66 [1.03-2.68]); associations were attenuated with cardiovascular risk factor adjustment. Sleeping <7 versus 8 to ≤9 hours was associated with higher risk of all-cause dementia (2.00 [1.03-3.86]). Discussion: When adjudicated outcome definitions were used, late-midlife OSA and short sleep duration were associated with all-cause and Alzheimer's disease dementia in later life.

Original languageEnglish (US)
JournalAlzheimer's and Dementia
DOIs
StateAccepted/In press - 2017

Fingerprint

Dementia
Atherosclerosis
Alzheimer Disease
Sleep
Obstructive Sleep Apnea
Risk Adjustment
Polysomnography
Apnea
Hospitalization
Odds Ratio
Confidence Intervals

Keywords

  • Alzheimer's disease
  • Atherosclerosis Risk in Communities (ARIC) Study
  • Dementia
  • Mild cognitive impairment
  • Obstructive sleep apnea
  • Sleep duration
  • Sleep Heart Health Study (SHHS)

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Geriatrics and Gerontology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health

Cite this

Lutsey, P. L., Misialek, J. R., Mosley, T. H., Gottesman, R. F., Punjabi, N. M., Shahar, E., ... Alonso, A. (Accepted/In press). Sleep characteristics and risk of dementia and Alzheimer's disease: The Atherosclerosis Risk in Communities Study. Alzheimer's and Dementia. https://doi.org/10.1016/j.jalz.2017.06.2269

Sleep characteristics and risk of dementia and Alzheimer's disease : The Atherosclerosis Risk in Communities Study. / Lutsey, Pamela L.; Misialek, Jeffrey R.; Mosley, Thomas H.; Gottesman, Rebecca F.; Punjabi, Naresh M.; Shahar, Eyal; MacLehose, Richard; Ogilvie, Rachel P.; Knopman, David S; Alonso, Alvaro.

In: Alzheimer's and Dementia, 2017.

Research output: Contribution to journalArticle

Lutsey, Pamela L. ; Misialek, Jeffrey R. ; Mosley, Thomas H. ; Gottesman, Rebecca F. ; Punjabi, Naresh M. ; Shahar, Eyal ; MacLehose, Richard ; Ogilvie, Rachel P. ; Knopman, David S ; Alonso, Alvaro. / Sleep characteristics and risk of dementia and Alzheimer's disease : The Atherosclerosis Risk in Communities Study. In: Alzheimer's and Dementia. 2017.
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