TY - JOUR
T1 - Sleep apnea and hypertension
AU - Hoffmann, M.
AU - Bybee, K.
AU - Accurso, V.
AU - Somers, V. K.
PY - 2004/8/1
Y1 - 2004/8/1
N2 - Obstructive sleep apaea (OSA) is the most common form of sleep-disordered breathing and frequently coexists with obesity. Almost 15 million Americans are affected by this disorder. This prevalence is likely increasing, given the current epidemic of obesity. Recent data confirm an association between sleep apnea and several cardiovascular disease conditions, suggesting that OSA may be a new risk factor for coronary artery disease, heart failure, heart rhythm disturbances and hypertension, independent of body mass index. In this review, the authors focus on the nature of the association between OSA and hypertension, the evidence suggesting a causal interaction, and discuss the potential pathophysiologic mechanisms responsible. These mechanisms include activation of the sympathetic and renin-angiotensin-aldosterone systems (RAAS), oxidative stress, and systemic and vascular inflammation, all of which could link OSA to a sustained increase in blood pressure. The authors also review potential therapeutic strategies for the hypertensive patient with OSA.
AB - Obstructive sleep apaea (OSA) is the most common form of sleep-disordered breathing and frequently coexists with obesity. Almost 15 million Americans are affected by this disorder. This prevalence is likely increasing, given the current epidemic of obesity. Recent data confirm an association between sleep apnea and several cardiovascular disease conditions, suggesting that OSA may be a new risk factor for coronary artery disease, heart failure, heart rhythm disturbances and hypertension, independent of body mass index. In this review, the authors focus on the nature of the association between OSA and hypertension, the evidence suggesting a causal interaction, and discuss the potential pathophysiologic mechanisms responsible. These mechanisms include activation of the sympathetic and renin-angiotensin-aldosterone systems (RAAS), oxidative stress, and systemic and vascular inflammation, all of which could link OSA to a sustained increase in blood pressure. The authors also review potential therapeutic strategies for the hypertensive patient with OSA.
KW - Apnea
KW - Hypertension
KW - Sleep
UR - http://www.scopus.com/inward/record.url?scp=6344252807&partnerID=8YFLogxK
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M3 - Review article
C2 - 15334042
AN - SCOPUS:6344252807
VL - 95
SP - 281
EP - 290
JO - Minerva Medicolegale
JF - Minerva Medicolegale
SN - 0026-4806
IS - 4
ER -