Sleep and neurodegenerative disorders

A review

Research output: Contribution to journalArticle

Abstract

The coexistence of neurodegenerative diseases and sleep disorders is increasingly being recognized. While there is considerable evidence suggesting that such conditions are inherent to the neurodegenerative process, most occur as a result of concomitant intrinsic and extrinsic factors. Primary sleep disorders such as obstructive sleep apnea and restless legs syndrome increase in prevalence with age, and can result in unique clinical scenarios and diagnostic challenges when combined with neurodegenerative diseases. Rapid-eye movement sleep behavior disorder appears to exhibit a predilection for specific neurodegenerative entities, and may therefore have diagnostic utility, and ultimately prove to be a useful marker to identify those best suited for studies investigating preventative therapies. Identification of all factors impacting sleep disturbances is important, as sleep complaints significantly influence the rate of institutionalization in the elderly. This review highlights various pathophysiologic and clinical investigations pertaining to sleep findings in Alzheimer's disease, dementia with Lewy bodies, Parkinson's disease, multiple system atrophy, and fatal familial insomnia.

Original languageEnglish (US)
Pages (from-to)267-295
Number of pages29
JournalMinerva Psichiatrica
Volume49
Issue number4
StatePublished - Dec 2008

Fingerprint

Neurodegenerative Diseases
Sleep
Alzheimer Disease
Fatal Familial Insomnia
REM Sleep Behavior Disorder
Multiple System Atrophy
Restless Legs Syndrome
Institutionalization
Intrinsic Factor
Obstructive Sleep Apnea
Parkinson Disease
Sleep Wake Disorders
Therapeutics

Keywords

  • Dementia
  • Insomnia, fatal familial
  • Lewy bodies disease
  • Multiple system atrophy
  • Neurodegenerative diseases
  • Parkinson disease
  • Sleep disorders

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Sleep and neurodegenerative disorders : A review. / Auger, Robert R.

In: Minerva Psichiatrica, Vol. 49, No. 4, 12.2008, p. 267-295.

Research output: Contribution to journalArticle

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