SLC1A2 rs3794087 does not associate with essential tremor

Jay P. Ross, Sruti Rayaprolu, Cecily Q. Bernales, Alexandra I. Soto-Ortolaza, Jay A Van Gerpen, Ryan J. Uitti, Zbigniew K Wszolek, Alex Rajput, Ali H. Rajput, Michele L. Rajput, Owen A Ross, Carles Vilariño-Güell

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13 Scopus citations

Abstract

A recent genome-wide association study of patients with essential tremor (ET) from Germany has nominated SLC1A2 rs3794087 as a novel risk factor for disease. This association was independently replicated in the Chinese population, albeit with an opposite direction of effect. To further define the role of SLC1A2 in ET, we genotyped rs3794087 in a North American series consisting of 1347 patients with ET and controls. Statistical analysis did not identify significant differences in genotype or allele frequencies between healthy controls and patients with ET (p > 0.36). These findings therefore do not support a role for SLC1A2 rs3794087 in susceptibility to ET in the North American population. Further studies in ethnically distinct populations of patients with ET are necessary to understand whether genetic variability in SLC1A2 affects disease risk for ET.

Original languageEnglish (US)
JournalNeurobiology of Aging
Volume35
Issue number4
DOIs
StatePublished - Apr 2014

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Keywords

  • Association
  • Essential tremor
  • SLC1A2

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Aging
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

Ross, J. P., Rayaprolu, S., Bernales, C. Q., Soto-Ortolaza, A. I., Van Gerpen, J. A., Uitti, R. J., Wszolek, Z. K., Rajput, A., Rajput, A. H., Rajput, M. L., Ross, O. A., & Vilariño-Güell, C. (2014). SLC1A2 rs3794087 does not associate with essential tremor. Neurobiology of Aging, 35(4). https://doi.org/10.1016/j.neurobiolaging.2013.09.022