Skeletal stem/osteoprogenitor cells: Current concepts, alternate hypotheses, and relationship to the bone remodeling compartment

Ulrike I. Mödder, Sundeep Khosla

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Plastic adherent bone marrow stromal cells have become synonymous with skeletal stem cells, and perhaps rightfully so, as these cells have been extremely well characterized over the past four decades, since their original description by Friedenstein. However, although this cell population is useful as an experimental model of precursors for osteoblasts and other mesenchymal lineages, the precise role of bone marrow stromal cells in bone remodeling, fracture repair, or repair of non-skeletal tissues remains unclear. Moreover, there is a conceptual problem in terms of postulating that these cells are osteoblast precursors at sites of bone remodel ing on trabecular surfaces adjacent to red marrow and yet having to posit potentially entirely different mechanisms for the origins of osteoblasts at sites of cortical bone remodeling distant from red marrow. Thus, the identification and characterization in recent years of non-adherent stem and osteoprogenitor cells in the bone marrow, of similar cells in the peripheral circulation, and of stem/osteoprogenitor cells arising either from the perivascular compartment (pericytes) or within the developing vascular wall itself, has suggested alternative candidate cell populations that may help to resolve the problem of postulating different mechanisms of remodeling in trabecular versus cortical bone. When coupled with our evolving understanding of the bone remodeling compartment (BRC), a closed cavity penetrated by capillaries which appears to be the site of remodeling in both trabecular and cortical bone, it is likely that our conceptual understanding of the fundamental mechanisms of bone remodeling will need to be modified.

Original languageEnglish (US)
Pages (from-to)393-400
Number of pages8
JournalJournal of Cellular Biochemistry
Volume103
Issue number2
DOIs
StatePublished - Feb 1 2008

Fingerprint

Bone Remodeling
Stem cells
Bone
Stem Cells
Osteoblasts
Mesenchymal Stromal Cells
Bone Marrow
Pericytes
Bone Fractures
Bone Marrow Cells
Population
Plastics
Blood Vessels
Theoretical Models
Bone and Bones
Repair
Cells
Cortical Bone
Tissue

Keywords

  • Bone
  • Osteoprogenitor
  • Stem cells

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

Cite this

Skeletal stem/osteoprogenitor cells : Current concepts, alternate hypotheses, and relationship to the bone remodeling compartment. / Mödder, Ulrike I.; Khosla, Sundeep.

In: Journal of Cellular Biochemistry, Vol. 103, No. 2, 01.02.2008, p. 393-400.

Research output: Contribution to journalArticle

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