Skeletal Muscle Progenitor Cell Heterogeneity

Dong Seong Cho, Jason Doles

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Tissue-specific stem cells contribute to adult tissue maintenance, repair, and regeneration. In skeletal muscle, many different mononuclear cell types are capable of giving rise to differentiated muscle. Of these tissue stem-like cells, satellite cells (SCs) are the most studied muscle stem cell population and are widely considered the main cellular source driving muscle repair and regeneration in adult tissue. Within the satellite cell pool, many distinct subpopulations exist, each exhibiting differential abilities to exit quiescence, expand, differentiate, and self-renew. In this chapter, we discuss the different stem cell types that can give rise to skeletal muscle tissue and then focus on satellite cell heterogeneity during the process of myogenesis/muscle regeneration. Finally, we highlight emerging opportunities to better characterize muscle stem cell heterogeneity, which will ultimately deepen our appreciation of stem cells in muscle development, repair/regeneration, aging, and disease.

Original languageEnglish (US)
Pages (from-to)179-193
Number of pages15
JournalAdvances in experimental medicine and biology
Volume1169
DOIs
StatePublished - Jan 1 2019

Keywords

  • Asymmetric division
  • Cell cycle
  • Cellular heterogeneity
  • Differentiation
  • Fibroblast
  • Mesenchymal stem cell
  • Muscle regeneration
  • Myogenesis
  • Pericyte
  • Satellite cell
  • Stem cell

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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